Review article: the many potential roles of intestinal serotonin (5 ‐hydroxytryptamine, 5‐HT) signalling in inflammatory bowel disease

ConclusionsInsights discussed in this review have strong potential to lead to new diagnostic and therapeutic tools to improve the management of IBD and other related disorders. Specifically, strategies that focus on modifying the activity of selective serotonin receptors and reuptake transporters in the gut could be effective for controlling disease activity and/or its associated symptoms. Further studies in humans are required, however, to more completely understand the pathophysiological mechanisms underlying the roles of 5‐HT in this setting.
Source: Alimentary Pharmacology and Therapeutics - Category: Drugs & Pharmacology Authors: Tags: REVIEW ARTICLE Source Type: research

Related Links:

CONCLUSION: NET-coated microbeads may be commercially developed as a novel tool for automated ANCA screening assays using flow cytometry. PMID: 30994385 [PubMed - in process]
Source: Autoimmunity - Category: Allergy & Immunology Tags: Autoimmunity Source Type: research
Authors: Ribaldone DG, Pellicano R, Actis GC Abstract An increasing deal of attention is being conveyed on the extra-intestinal manifestations of inflammatory bowel diseases (IBD). We compiled the present review in an attempt to upgrade the accuracy of the classification of such polymorphic entities. We focused on three patterns. First, the conventional extra-intestinal manifestations localized to bone and joints, to the eye, to the biliary tree and to the skin. Second, the so-called IBD-like syndromes accompanied by bone marrow-derived anomalies of innate or acquired immunity. Third, specific disorders of the skin...
Source: Minerva Gastroenterologica e Dietologica - Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research
We have read with great interest the recently published article by Pellet et  al.1 The authors assessed the efficacy and safety of calcineurin inhibitors as an induction therapy combined with vedolizumab as a maintenance therapy in a cohort of patients with steroid and anti–tumor necrosis factor–refractory ulcerative colitis (UC), using colectomy-free survival as the pr imary end point. Interestingly, this retrospective study identified the female sex, the presence of hemoglobin (Hb) greater than 11.2 g/dL, age, and concomitant immunosuppressant as baseline factors associated with colectomy.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research
We read with great interest the article by Hanauer et  al.1 Their study showed that tofacitinib induction therapy for ulcerative colitis results in a rapid clinical response. We recently used tofacitinib and infliximab as combination rescue therapy to avoid colectomy in a hospitalized patient with severe ulcerative colitis. We also observed a very rap id onset of action.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research
Conventional imaging techniques accurately detect strictures in patients with Crohn's disease, but magnetic resonance enterography (MRE) best differentiates fibrotic from inflammatory components, researchers say.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Gastroenterology News Source Type: news
Condition:   Ulcerative Colitis (UC) Interventions:   Drug: TD-1473 Dose A;   Drug: TD-1473 Dose B;   Drug: TD-1473 Dose C Sponsor:   Theravance Biopharma Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Conclusion: This case of thyroid bed PG supports the idea that PG reflects a cutaneous phenotype encompassed in the spectrum of systemic neutrophilic diseases. Endocrinologists should be aware that thyroid bed PG involvement is an albeit rare differential diagnosis to consider in patients who had undergone thyroid surgery, especially with a history of PG. Introduction Papillary thyroid carcinoma (PTC), the main variant of differentiated thyroid carcinoma (DTC), is the most common thyroid cancer, accounting for 70–80% of all thyroid carcinomas and occurring predominantly in women, generally with a good prognos...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
In conclusion, our study might provide evidence that GQD treats diarrhea maybe involved in modulating gut microbiota and increasing SCFA levels. Introduction Diarrheal diseases cause approximately 1.7 billion new infections and 0.76 million deaths in children of under 5 years of age annually and are thus the second most common cause of mortality in young children in developing countries (Kotloff et al., 2012, 2013). Outbreaks of such diseases are usually related to infection by common causative agents, mainly rotavirus, Salmonella enterica, and diarrheagenic Escherichia coli (Hodges and Gill, 2010; Kolenda et al., ...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Conclusion Microorganisms are involved in many life activities, and affect their surrounding environment and other organisms. Microorganisms play important roles in human heath, crop growth, livestock farming, environmental management, industrial chemical production and food production. In the 19th century, people first observed microbes using microscopes and began to study them. However, the development of high-throughput sequencing technology has led to generation of large amounts of microbial related data. As a result, machine-learning methods are now being applied to microbiological research. Here, we discuss the curr...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
In conclusion, severe lethal ileitis induced by oral T. gondii infection is attenuated by blockade of ST2 signaling and may be mediated in part by endogenous IL-22. Introduction Toxoplasma gondii is an opportunistic parasite with a worldwide distribution triggering an innate immune response. This response characterized by a rapid recruitment of neutrophils following the entry of infectious tachyzoites from the lumen into the intestinal mucosa eliciting a strong inflammatory Th1 response associated with the production of IFNγ, IL-12 and TNF-α. The parasite activates dendritic cells and macrophages to pro...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
More News: Drugs & Pharmacology | Gastroenterology | Inflammatory Bowel Disease | Study