Review article: the many potential roles of intestinal serotonin (5 ‐hydroxytryptamine, 5‐HT) signalling in inflammatory bowel disease

ConclusionsInsights discussed in this review have strong potential to lead to new diagnostic and therapeutic tools to improve the management of IBD and other related disorders. Specifically, strategies that focus on modifying the activity of selective serotonin receptors and reuptake transporters in the gut could be effective for controlling disease activity and/or its associated symptoms. Further studies in humans are required, however, to more completely understand the pathophysiological mechanisms underlying the roles of 5‐HT in this setting.
Source: Alimentary Pharmacology and Therapeutics - Category: Drugs & Pharmacology Authors: Tags: REVIEW ARTICLE Source Type: research

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CONCLUSION: NET-coated microbeads may be commercially developed as a novel tool for automated ANCA screening assays using flow cytometry. PMID: 30994385 [PubMed - in process]
Source: Autoimmunity - Category: Allergy & Immunology Tags: Autoimmunity Source Type: research
Authors: Ribaldone DG, Pellicano R, Actis GC Abstract An increasing deal of attention is being conveyed on the extra-intestinal manifestations of inflammatory bowel diseases (IBD). We compiled the present review in an attempt to upgrade the accuracy of the classification of such polymorphic entities. We focused on three patterns. First, the conventional extra-intestinal manifestations localized to bone and joints, to the eye, to the biliary tree and to the skin. Second, the so-called IBD-like syndromes accompanied by bone marrow-derived anomalies of innate or acquired immunity. Third, specific disorders of the skin...
Source: Minerva Gastroenterologica e Dietologica - Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research
We have read with great interest the recently published article by Pellet et  al.1 The authors assessed the efficacy and safety of calcineurin inhibitors as an induction therapy combined with vedolizumab as a maintenance therapy in a cohort of patients with steroid and anti–tumor necrosis factor–refractory ulcerative colitis (UC), using colectomy-free survival as the pr imary end point. Interestingly, this retrospective study identified the female sex, the presence of hemoglobin (Hb) greater than 11.2 g/dL, age, and concomitant immunosuppressant as baseline factors associated with colectomy.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research
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Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research
Conventional imaging techniques accurately detect strictures in patients with Crohn's disease, but magnetic resonance enterography (MRE) best differentiates fibrotic from inflammatory components, researchers say.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Gastroenterology News Source Type: news
Condition:   Ulcerative Colitis (UC) Interventions:   Drug: TD-1473 Dose A;   Drug: TD-1473 Dose B;   Drug: TD-1473 Dose C Sponsor:   Theravance Biopharma Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusion: This case of thyroid bed PG supports the idea that PG reflects a cutaneous phenotype encompassed in the spectrum of systemic neutrophilic diseases. Endocrinologists should be aware that thyroid bed PG involvement is an albeit rare differential diagnosis to consider in patients who had undergone thyroid surgery, especially with a history of PG. Introduction Papillary thyroid carcinoma (PTC), the main variant of differentiated thyroid carcinoma (DTC), is the most common thyroid cancer, accounting for 70–80% of all thyroid carcinomas and occurring predominantly in women, generally with a good prognos...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
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Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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