Designer T Cells Fight Viruses After Transplants
WASHINGTON (AP) — Bone marrow transplants save thousands of lives but patients are vulnerable to severe viral infections in the months afterward, until their new immune system kicks in. Now scientists are developing protection for that risky period — injections of cells specially designed to fend off up to five different viruses at once. MoreNo Streams for You? What Supreme Court's Aereo Ruling Means NBC NewsJessica N. Turner: Moms, Put on That Swimsuit Huffington PostKnow a Debbie Downer? Stop Trying to Cheer Her Up NBC NewsViva! Pope Francis Flaunts Argentina Soccer Jersey NBC NewsUruguay eliminates Italy; Did Suarez bite again? Sports Illustrated“These viruses are a huge problem, and there’s a huge need for these products,” said Dr. Ann Leen, who leads a team at Baylor College of Medicine and Texas Children’s Hospital that found an easier way to produce these long-desired designer T cells. Healthy people have an army of T cells that roams the body, primed to recognize and fight viruses. People with suppressed immune systems — such as those undergoing a bone marrow transplant to treat leukemia or other diseases — lack that protection. It can take anywhere from four months to more than a year for marrow stem cells from a healthy donor to take root and start producing new immune cells for the recipient. When patients get sick before then, today’s antiviral medications don’t always work and cause lots of side effects....
Publication date: Available online 20 August 2018Source: NeurocomputingAuthor(s): Junjie Zhang, Yong Xia, Haoyue Zeng, Yanning ZhangAbstractDetection of pulmonary nodules on chest CT is an essential step in the early diagnosis of lung cancer, which is critical for best patient care. In this paper, we propose an automated pulmonary nodule detection algorithm, denoted by NODULe, which jointly uses a conventional method for nodule detection and a deep learning model for genuine nodule identification. Specifically, we first use multi-scale Laplacian of Gaussian (LoG) filters and prior shape and size constraints to detect nodul...
ConclusionLow PNI predicts poor survival in LC patients.
CONCLUSIONS: This study shows that IHC with the tested antiserum increases the sensitivity of the diagnosis and may be recommended for routine use in EMB analyses of cardiac transplant patients with Chagas disease.
Imogen Riddett, 22, from Windsor, is literally a life-saver after stem cells she donated helped stranger, Claire Daly, from Coventry, overcome leukaemia aged 30.
There's a big survival gap between white and minority children when it comes to some childhood cancers. It turns out growing up in poverty explains a lot of the difference.(Image credit: FS Productions/Blend Images/Getty Images)
The findings by Columbia University add to the large body of evidence linking factors like education, income and access and affordability of care to worse survival rates for cancer.
Integrative medicine, bogus cancer treatment, antiaging, low T, and more -- what do you need to know about the proliferation of these clinics in medicine?Medscape Public Health
Publication date: 1 December 2018Source: Sensors and Actuators B: Chemical, Volume 275Author(s): Girija Gaur, Shuren Hu, Raymond L. Mernaugh, Ivan I. Kravchenko, Scott T. Retterer, Sharon M. WeissAbstractHighly sensitive detection of heat denatured Herceptin® (trastuzumab), an important monoclonal antibody used in breast cancer therapeutics, is demonstrated using transverse magnetic (TM) mode suspended microring resonators (MRRs). The suspended MRRs are surface functionalized with a single chain fragment variable (scFv) recombinant antibody molecule (designated 2B4) that enables selective capture of denatured Herceptin...
The interaction between HSA and two semi-synthetic potential anti-cancer agents derived from trans -dehydrocrotonin-methyl-hydrazone (MHDCTN) and phenyl-hydrazone (PHDCTN) was evaluated under physiological conditions at 296, 303 and 310 K by multi-spectroscopic techniques and molecular docking calculations. Steady state fluorescence quenching indicated a ground state association (static quenching) for both samples; however, the quenching induced by PHDCTN was not essentially static and can be accompanied by a dynamic quenching mechanism. The binding is strong (modified Stern-Volmer binding constant (Ka) ca. 105 M-1), causi...
Rather than burden his parents with the expense of his treatment, Tang Gongwei chose to disappear.
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