Analysis of CD15, CD57 and HIF-1 α in biopsies of patients with peri-implantitis

Publication date: Available online 23 July 2017 Source:Pathology - Research and Practice Author(s): Márcia Fernandes de Araújo, Renata Margarida Etchebehere, Marcelo Luiz Ribeiro de Melo, Marcela Beghini, Viviane Oliveira Severino, Eliângela de Castro Côbo, Denise Bertulucci Rocha Rodrigues, Sanívia Aparecida de Lima Pereira Peri-implantitis is an infectious disease characterized by inflammation of the tissues surrounding the implant, bleeding on probing with or without suppuration, and bone loss. Peri-implant lesions contain a leukocyte infiltrate of plasma cells, lymphocytes, macrophages and neutrophils. A survey of the literature did not show any studies reporting an association between hypoxia and peri-implantitis. The aim of the present cross-sectional study was to evaluate histological changes and immunostaining for CD15, CD57 and HIF-1α in the peri-implant mucosa of patients with and without peri-implantitis. Mucosal biopsies were obtained from 18 patients with peri-implantitis and 10 control subjects without peri-implantitis at a private health care center between 2010 and 2012. The sections were fixed in 10% buffered formalin, processed and embedded in paraffin for histopathological and immunohistochemical study. Acanthosis, spongiosis and exocytosis were observed in both groups, with no significant difference between them. The peri-implantitis group showed increased immunostaining for CD15, a neutrophil marker, and HIF-1α, a tissue hypoxia marker, b...
Source: Pathology Research and Practice - Category: Pathology Source Type: research