Fight Aging! Newsletter, July 24th 2017
In this study, we asked how POD is influenced by different experimental practices and how likely it is that underpowered experiments lead to scientific disputes between two groups conducting identical experiments. To address these questions, we generated a parametric model based on the Gompertz equation using lifespan data of 5,026 C. elegans. We then used this model to simulate lifespan experiments with different conditions to determine how experimental parameters affect the ability to detect lifespan increases of certain sizes. We considered two important experimental features that contribute to the workload of lifespan experiments: frequency of scoring and number of animals in each cohort. Our data show that the POD is greatly affected by the number of animals in each group, but less so by scoring frequency. We further show how inappropriately powered experiments negatively affect reproducibility. Our results make clear that current standard practices are unlikely to produce consistently reproducible results for real longevity effects below 20%, even under ideal conditions.
Reducing Inflammation Assists Stem Cell Therapies to Enhance Regeneration
https://www.fightaging.org/archives/2017/07/reducing-inflammation-assists-stem-cell-therapies-to-enhance-regeneration/
The immune system is highly influential in the processes of regeneration. Inflammation is a key marker of the types of immune cell involved and the sort of activities they are undertaking, eit...
Source: Fight Aging! - Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
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