Calcineurin inhibitor withdrawal or tapering for kidney transplant recipients.

CONCLUSIONS: CNI avoidance increased acute rejection and CNI withdrawal increases acute rejection but reduced graft loss at least over the short-term. Low dose CNI with induction regimens reduced acute rejection and graft loss with no major adverse events, also in the short-term. The use of mTOR-I reduced CMV infections but increased the risk of acute rejection. These conclusions must be tempered by the lack of long-term data in most of the studies, particularly with regards to chronic antibody-mediated rejection, and the suboptimal methodological quality of the included studies. PMID: 28730648 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/28730648?dopt=Abstract

Source: Cochrane Database of Systematic Reviews - July 21, 2017 Category: General Medicine Authors: Karpe KM, Talaulikar GS, Walters GD Tags: Cochrane Database Syst Rev Source Type: research