Age of menarche is associated with knee joint replacement due to  primary osteoarthritis (The HUNT Study and the Norwegian Arthroplasty Register)

To investigate whether parity, age at menarche, menopausal status, age at menopause, use of oral contraceptives (OC) or use of hormone replacement therapy (HRT) were associated with total knee replacement (TKR) or total hip replacement (THR) due to primary osteoarthritis.

Source: Osteoarthritis and Cartilage - July 10, 2017 Category: Rheumatology Authors: A.I. Hellevik, L. Nordsletten, M.B. Johnsen, A.M. Fenstad, O. Furnes, K. Storheim, J.A. Zwart, G. Flugsrud, A. Langhammer Source Type: research