Comparative effects of vitamin D and methylprednisolone against ischemia/reperfusion injury of rabbit spinal cords.

Comparative effects of vitamin D and methylprednisolone against ischemia/reperfusion injury of rabbit spinal cords. Eur J Pharmacol. 2017 Jul 17;: Authors: Gürer B, Karakoç A, Bektaşoğlu PK, Kertmen H, Kanat MA, Arıkök AT, Ergüder Bİ, Sargon MF, Öztürk ÖÇ, Çelikoğlu E Abstract INTRODUCTION: Recent studies have demonstrated the neuroprotective and immunomodulatory effects of 1,25-dihydroxyvitamin D3 (calcitriol), but no previous study has examined these effects on spinal cord ischemia/reperfusion (I/R) injury. Therefore, the present study aimed to evaluate whether calcitriol protects the spinal cord from I/R injury. METHODS: Rabbits were randomized into four groups of eight animals: group 1 (laparotomy control), group 2 (ischemia control), group 3 (30mg/kg intraperitoneal methylprednisolone at surgery), and group 4 (0.5μg/kg, intraperitoneal calcitriol for 7 days before I/R injury). The rabbits in the laparotomy control group underwent laparotomy only, whereas all rabbits in the other groups were subject to spinal cord ischemia by aortic occlusion for 20min, just caudal to the renal artery. Malondialdehyde and catalase levels, myeloperoxidase and xanthine oxidase activities, and caspase-3 concentrations were analyzed. Finally, histopathological, ultrastructural, and neurological evaluations were performed. RESULTS: After I/R injury, increases in malondialdehyde levels, myeloperoxidase an...
Source: European Journal of Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Eur J Pharmacol Source Type: research

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Conclusion: I/R injury of the spinal cord can be successfully demonstrated by aortic clamping in this surgical model. Betanin/Copper sulphate has ameliorative effects against operative I/R injury. Low toxicity of those agents makes them ideal targets for clinical research for this purpose. PMID: 32223592 [PubMed - as supplied by publisher]
Source: Journal of Spinal Cord Medicine - Category: Orthopaedics Tags: J Spinal Cord Med Source Type: research
Conclusion: The results suggest that pre- and post-treatment with EGCG may be effective in protecting spinal cord from IRI. PMID: 31809244 [PubMed - as supplied by publisher]
Source: Journal of Spinal Cord Medicine - Category: Orthopaedics Tags: J Spinal Cord Med Source Type: research
Conclusions: This series presents our laparoscopic technique for continent urinary diversions, showing that it is feasible and safe in adult patients with neurogenic bladder.
Source: Urology Annals - Category: Urology & Nephrology Authors: Source Type: research
We report a case of steel rod impalement involving the spinal canal and review the literature to enhance the management strategies and to identify the risk factors for possible complications, particularly infection. A 37-year-old male construction worker presented to our emergency department due to falling onto a concrete reinforcing steel rod that penetrated through his perineum to the L4 vertebra. Examination revealed paralysis and sensory loss of the left foot. The rod was removed in the operating room (closed removal) under general anesthesia, followed by laparotomy. Rectal laceration was primarily repaired, and colost...
Source: Turkish Journal of Trauma and Emergency Surgery : TJTES - Category: Emergency Medicine Authors: Tags: Ulus Travma Acil Cerrahi Derg Source Type: research
DISCUSSION: In patients with blunt abdominal trauma, the finding of isolated free fluid on abdominal CT alone is no longer an indication for laparotomy. Other clinical factors must be taken into account when deciding on the need for laparotomy, such as haemodynamic status, clinical abdominal findings and the ability to reliably assess the abdomen. In the absence of a clinical indication for urgent laparotomy, patients with isolated free fluid may be observed. PMID: 31219321 [PubMed - as supplied by publisher]
Source: Annals of the Royal College of Surgeons of England - Category: Surgery Authors: Tags: Ann R Coll Surg Engl Source Type: research
In this study, spontaneous baroreflex sensitivity (SBRS) was also calculated through the sequence method by the computer software CardioSeries (v2.4). A baroreflex sequence was defined as a sequence of at least four heart beats in which both systolic arterial pressure and pulse interval increased (up sequences) or decreased (down sequences) as previously described (Braga et al., 2008). Evaluation of Sympathetic Tonus to the Vasculature In a separate group of rats, the sympathetic vascular tone was evaluated by an intravenous injection of hexamethonium (30 mg/Kg, Sigma-Aldrich, São Paulo, Brazil), a ganglionic bloc...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
In this study, we hypothesized that tetracosactide may have protective effects in spinal cord ischemia-reperfusion injury. Material and methods: Rabbits were randomized into the accompanying four groups of eight animals each: group 1 (control), group 2 (ischemia), group 3 (methylprednisolone) and group 4 (tetracosactide). In the control group, just a laparotomy was performed. In the various groups, the spinal cord ischemia model was made by the impediment of the aorta only caudal to the renal vein. Neurological assessment was conducted with the Tarlov scoring system. Levels of myeloperoxidase, malondialdehyde and catal...
Source: Archives of Medical Science - Category: Biomedical Science Tags: Arch Med Sci Source Type: research
Conclusion This trial demonstrates ease of placement, removal, functionality and safety of temporary DP electrodes which therapeutically decreases diaphragm atrophy.
Source: The American Journal of Surgery - Category: Surgery Source Type: research
CONCLUSION: Pneumatosis intestinalis and hepatic portal venous gas are radiographic findings that can be associated with bowel ischemia. The clinical status of the patient should guide operative management. There is no evidence to suggest that there is an association with spinal trauma and pneumatosis intestinalis or hepatic portal venous gas. PMID: 27328580 [PubMed - in process]
Source: Connecticut Medicine - Category: Journals (General) Authors: Tags: Conn Med Source Type: research
31-year old male presented with complaints of shoulder, neck and upper back pain, numbness of the genitalia, and difficulty voiding. He described "knots around the muscles of the chest." Patient was unable to identify a causative event. There was overall feeling of weakness. The patient reported a sensation of numbness in the genitalia over the same period. He was still capable of having erections, but ejaculations only occurred intermittently. Patient mentioned he experienced difficulty with voiding without incontinence... His medical history is significant idiopathic retroperitoneal fibrosis, for which he under...
Source: Neurology - Category: Neurology Authors: Tags: Cerebrovascular Disease: Spinal Cord Involvement and Traumatic Brain Injury Source Type: research
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