Novel Menadione Hybrids: Synthesis, anticancer activity and cell based studies
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Menadione based triazole hybrids were synthesized by employing copper catalyzed azide‐alkyne cycloaddition (CuAAC). The synthesized compounds were evaluated for their anticancer activity against five selected cancer cell lines. Compound 6 showed higher potency than the standard tamoxifen and parent menadione against MCF‐7 cell line, arrested cell cycle at G0/G1 phase and induced apoptotic cell death.
Source: Chemical Biology and Drug Design - Category: Biology Authors: Chakka Vara Prasad, Vadithe Lakshma Nayak, Sistla Ramakrishna, Uppuluri Venkata Mallavadhani Tags: Research Article Source Type: research
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