Association of clinical and serological parameters of Systemic Lupus Erythematosus patients with Epstein ‐Barr virus antibody profile

This study demonstrated a significant increase in EBV VCA‐IgG, VCA‐IgM and EBNA‐IgG antibodies levels of SLE patients when compared to healthy controls (p<0.05). High seroprevalence was seen in both the study groups for EBV VCA‐IgG and EBNA‐IgG antibodies when compared to VCA‐IgM antibodies. A significant increase was noted in the anti‐VCA‐IgG levels with dsDNA autoantibody positivity (p<0.05). Though there was no significant association between EBV antibody profile and clinical manifestations, 100% seropositivity for anti‐VCA‐IgG was seen in SLE patients with renal manifestations. Association of anti‐VCA IgG levels with presence of anti‐dsDNA antibodies suggests a possible role of EBV as an environmental trigger in pathogenesis of SLE. This article is protected by copyright. All rights reserved

Source: Journal of Medical Virology - July 22, 2017 Category: Virology Authors: Chougule D, Nadkar M, Rajadhyaksha A, Pandit P, Surve P, Dawkar N, Khadilkar P, Patwardhan M, Kaveri SV, Ghosh K, Pradhan V Tags: Research Article Source Type: research