Lanostane triterpenoids from cultivated fruiting bodies of the basidiomycete Ganoderma orbiforme

Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Masahiko Isaka, Panida Chinthanom, Sermsiri Mayteeworakoon, Kobkul Laoteng, Rapheephat Suvannakad, Rattaket Choeyklin A new 3,4-seco-27-norlanostane triterpene, ganoboninketal D (1), a new lanostane, (24S)-3-oxo-7α,24,25-trihydroxylanosta-8-ene (2), together with six known lanostanes (3–8), were isolated from cultivated fruiting bodies of the basidiomycete Ganoderma orbiforme. The structures were elucidated on the basis of NMR spectroscopic and mass spectrometry data, and the structures 1 and 2 were further confirmed by chemical correlations to ganoboninketal C and ganodermanondiol, respectively. All isolated compounds were inactive in the antitubercular and antimalarial activity assays against Mycobacterium tuberculosis H37Ra and Plasmodium falciparum K1, respectively, except that compound 8 exhibited weak antitubercular activity (MIC 50μg/ml). Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research