New pacemaker offers heart failure hope

ConclusionThis laboratory research describes the complex design and animal testing of an ACPG that aims to restore the natural synchronisation of the heart rate with the breathing pattern. Naturally in the body, our heart rate alters slightly as we breathe in and out (RSA). In people with heart failure (a disease process with many causes, where the heart is unable to pump enough blood to meet the body’s demands), RSA is described as being "lost", and previous research has suggested this to be a prognostic indicator for poor outcome.This research described the development of an ACPG and its testing in rats. The generator received incoming signals from the phrenic connected to the diaphragm, and then produced voltage oscillations that stimulated the vagus nerve, which controls heart rate. The results were promising, demonstrating that the technology was able to coordinate the heart rate with breathing pattern. The heart rate varied, depending on the stage during breathing that the vagus nerve was stimulated. When stimulated during the inspiratory phase, it decreased heart rate by around 50% of the normal rate, but had little effect on heart rate during the late expiratory phase. Overall, this technique shows promise, but having only so far been tested in rats in the laboratory, it is far too early to tell if and when it will be developed for testing in humans and, importantly, whether it would actually have any effect on health outcomes.We expect that further an...
Source: NHS News Feed - Category: Consumer Health News Tags: Heart/lungs Medical practice Source Type: news

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Publication date: Available online 21 March 2019Source: MitochondrionAuthor(s): Hamza El Hadi, Roberto Vettor, Marco RossatoAbstractCardiovascular disease is the leading cause of diabetes-related morbidity and mortality. It is widely accepted that heart failure risk is increased in diabetic patients even after adjusting for coronary artery disease and hypertension. Mitochondria are the center of fatty acid (FA) and glucose metabolism and thus are likely to be impacted by impaired metabolism associated with diabetes. Although the cause of this increased heart failure risk is multifactorial, increasing evidence points toward...
Source: Mitochondrion - Category: Biochemistry Source Type: research
Publication date: April 2019Source: Archives of Cardiovascular Diseases Supplements, Volume 11, Issue 2Author(s): M. Gandon-Renard, F. Lefebvre, D. Courilleau, S. Gomez, P. Gerbaud, A.M. Gomez, J.J. MercadierCardiac ryanodine receptors (RyR2) have a key role in excitation-contraction coupling by releasing Ca2+ from sarcoplasmic reticulum (SR). In cardiomyocytes, 2 FK506 binding protein (FKBP) isoforms have been shown to bind and to stabilize RyR2 opening: FKBP12 and FKBP12.6, the later having a stronger affinity for RyR2 despite its lower abundance. Cardiac-specific FKBP12.6 overexpressing mice have fewer arrhythmias induc...
Source: Archives of Cardiovascular Diseases Supplements - Category: Cardiology Source Type: research
ConclusionHis bundle pacing was feasible and safe after a one-year experience. His bundle capture thresholds slightly decreased at 3 months follow-up.
Source: Archives of Cardiovascular Diseases Supplements - Category: Cardiology Source Type: research
Publication date: April 2019Source: Archives of Cardiovascular Diseases Supplements, Volume 11, Issue 2Author(s): A. Bourcier, C. Coquard, J. Margaria, S. Gomez, A. Varin, A. Ghigo, V. Algalarrondo, G. Vandecasteele, E. Hirsch, R. Fischmeister, J. LeroyChronic beta-AR activation is detrimental because it promotes cardiac remodeling and ultimately leads to heart failure (HF). Multiple cyclic nucleotide phosphodiesterases (PDEs) finely tune beta-AR responses by degrading and compartmentalizing cAMP. Since chronic treatment with PDE inhibitors increases mortality in HF, we postulated that decreasing cAMP levels by overexpress...
Source: Archives of Cardiovascular Diseases Supplements - Category: Cardiology Source Type: research
AbstractGrowth differentiation factor 11 (GDF11) is a member of the transforming growth factor beta 1 (TGF- β1) superfamily that reverses age-related cardiac hypertrophy, improves muscle regeneration and angiogenesis, and maintains progenitor cells in injured tissue. Recently, targeted myocardial delivery of theGDF11 gene in aged mice was found to reduce heart failure and enhance the proliferation of cardiac progenitor cells after myocardial ischemia –reperfusion (I–R). No investigations have as yet explored the cardioprotective effect of exogenous recombinant GDF11 in acute I–R injury, despite the c...
Source: Basic Research in Cardiology - Category: Cardiology Source Type: research
Authors: Boutagy NE, Feher A, Alkhalil I, Umoh N, Sinusas AJ Abstract Multimodality cardiovascular imaging is routinely used to assess cardiac function, structure, and physiological parameters to facilitate the diagnosis, characterization, and phenotyping of numerous cardiovascular diseases (CVD), as well as allows for risk stratification and guidance in medical therapy decision-making. Although useful, these imaging strategies are unable to assess the underlying cellular and molecular processes that modulate pathophysiological changes. Over the last decade, there have been great advancements in imaging instrumenta...
Source: Comprehensive Physiology - Category: Physiology Tags: Compr Physiol Source Type: research
Patients admitted with advanced decompensated systolic heart failure (ADHF) typically require inotropes. Those who cannot be bridged to advanced heart failure therapies are discharged home on inotropes (as a palliative measure or until eligible for advanced therapies). Continuous inotrope infusion exposes patients to increased risk of arrhythmias and mortality. It is unknown whether such patients can be weaned off inotropic support in an outpatient setting.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 962 Source Type: research
Bioelectrical impedance analysis (BIA) is a painless and safe way to measure body composition without radiation. It is feasible in immobile patients and may serve as a measure to assess frailty. BIA may lead to electromagnetic interference with the conduction system of the heart, provoking oversensing in pacemakers and internal cardiac defibrillators or arrhythmias. End-stage heart failure patients are at highest risk for these possible side effects. The aim of this study was to evaluate the safety of BIA in end-stage heart failure patients under pro-arrhythmogenic pharmacologic therapy.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 948 Source Type: research
In conclusion, our case illustrated that CS should be considered in ELBW infants showing a life-threatening combination of complex cardiac arrhythmia and hypokinesia. If a syndromic disorder is suspected in the neonatal intensive care unit (NICU) setting, WES is a useful, non-invasive diagnostic tool in critically ill ELBW infants.
Source: Molecular and Cellular Probes - Category: Molecular Biology Source Type: research
Biotronik said yesterday it won FDA approval for its Acticor and Rivacor high-voltage cardiac rhythm management devices intended for treating patients with cardiac arrhythmias. The clearance covers the Berlin, Germany based company’s Rivacor VR-T, Rivacor DR-T, Rivacor HF-T QP, Acticor DX, Acticor CRT-DX Bipolar and Acticor CRT-DX devices. “When determining the best treatment plan for each patient, we assess individual needs and select a device system that provides optimal therapy programming with critical diagnostic features. We are often forced to choose between important features, which could compromise opti...
Source: Mass Device - Category: Medical Devices Authors: Tags: Cardiac Assist Devices Cardiac Implants Cardiovascular Featured Food & Drug Administration (FDA) Regulatory/Compliance Biotronik Source Type: news
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