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New pacemaker offers heart failure hope

ConclusionThis laboratory research describes the complex design and animal testing of an ACPG that aims to restore the natural synchronisation of the heart rate with the breathing pattern. Naturally in the body, our heart rate alters slightly as we breathe in and out (RSA). In people with heart failure (a disease process with many causes, where the heart is unable to pump enough blood to meet the body’s demands), RSA is described as being "lost", and previous research has suggested this to be a prognostic indicator for poor outcome.This research described the development of an ACPG and its testing in rats. The generator received incoming signals from the phrenic connected to the diaphragm, and then produced voltage oscillations that stimulated the vagus nerve, which controls heart rate. The results were promising, demonstrating that the technology was able to coordinate the heart rate with breathing pattern. The heart rate varied, depending on the stage during breathing that the vagus nerve was stimulated. When stimulated during the inspiratory phase, it decreased heart rate by around 50% of the normal rate, but had little effect on heart rate during the late expiratory phase. Overall, this technique shows promise, but having only so far been tested in rats in the laboratory, it is far too early to tell if and when it will be developed for testing in humans and, importantly, whether it would actually have any effect on health outcomes.We expect that further an...
Source: NHS News Feed - Category: Consumer Health News Tags: Heart/lungs Medical practice Source Type: news

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Source: Circulation: Heart Failure - Category: Cardiology Authors: Tags: Arrhythmias, Catheter Ablation and Implantable Cardioverter-Defibrillator, Sudden Cardiac Death, Heart Failure On My Mind Source Type: research
In conclusion the patients undergoing TV surgery are complex and only a detailed anesthesiological and surgical workup may decrease the perioperative mortality and morbidity. PMID: 29642696 [PubMed - as supplied by publisher]
Source: Minerva Cardioangiologica - Category: Cardiology Tags: Minerva Cardioangiol Source Type: research
Conclusions: Even with ovarian conservation, hysterectomy is associated with an increased long-term risk of cardiovascular and metabolic conditions, especially in women who undergo hysterectomy at age ≤35 years. If these associations are causal, alternatives to hysterectomy should be considered to treat benign gynecologic conditions.
Source: Menopause - Category: OBGYN Tags: Original Articles Source Type: research
Conclusions: Computer simulations revealed that intrinsic interventricular dyssynchrony is the dominant component of the electrical substrate driving the response to CRT. Intrinsic intraventricular dyssynchrony and any dyssynchrony during biventricular pacing play a minor role in this respect. This may facilitate patient-specific modeling for prediction of CRT response. Clinical Trial Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01270646.
Source: Circulation: Arrhythmia and Electrophysiology - Category: Cardiology Authors: Tags: Electrophysiology, Computational Biology, Heart Failure, Pacemaker Original Articles Source Type: research
Conclusions: The combination of LGE and wQRS provides additional prognostic stratification compared with LGE status alone and might improve the appropriate use of implantable cardioverter defibrillator therapy in patients with dilated cardiomyopathy.
Source: Circulation: Arrhythmia and Electrophysiology - Category: Cardiology Authors: Tags: Arrhythmias, Sudden Cardiac Death, Heart Failure Original Articles Source Type: research
In conclusion, repeated oral dosing with RDX7675 over 4 days reduced potassium absorption in healthy volunteers; the results support QD dosing of RDX7675 in future clinical studies. PMID: 29645278 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Authors: Tags: J Clin Pharmacol Source Type: research
Conclusions: Chinese-language CVD resources were inconsistent in the supply of key information. Quality and level of cultural sensitivity were adequate, but most resources lacked culturally specific references. Comprehensive, high-quality CVD resources powered by Editorial Manager and ProduXion Manager from Aries Systems Corporation tailored for Chinese immigrants are urgently needed for healthcare providers to support CVD education and care of patients belonging to this population.
Source: Journal of Cardiovascular Nursing - Category: Nursing Tags: ARTICLES: Instrument Adaptation Source Type: research
Authors: Iwazaki K, Kojima T, Murasawa T, Yokota J, Tanimoto H, Matsuda J, Fukuma N, Matsubara T, Shimizu Y, Oguri G, Hasumi E, Kubo H, Chang K, Fujiu K, Komuro I Abstract A cardiac resynchronization therapy defibrillator (CRT-D) (Medtronic Inc. Protecta XT) was implanted in a 67-year-old man who had cardiac sarcoidosis with extremely low cardiac function. He had ventricular tachycardia which was controlled by catheter ablation, medication and pacing. The programmed mode was DDI, lower rate was 90 beats/minute, paced AV delay was 150 ms, and the noncompetitive atrial pacing (NCAP) function was programmed as 300 ms....
Source: International Heart Journal - Category: Cardiology Tags: Int Heart J Source Type: research
AbstractIn the clinical practice of cardiovascular critical care, we often observe a variety of arrhythmias in the patients either with (secondary) or without (idiopathic) underlying heart diseases. In this manuscript, the clinical background and management of various arrhythmias treated in the CCU/ICU will be reviewed.The mechanism and background of lethal ventricular tachyarrhythmias vary as time elapses after the onset of MI that should be carefully considered to select a most suitable therapy. In the category of non-ischemic cardiomyopathy, several diseases are known to be complicated by the various ventricular tachyar...
Source: Journal of Intensive Care - Category: Intensive Care Source Type: research
AbstractPurpose of reviewThis review describes cardiotoxicity associated with adoptive T cell therapy and immune checkpoint blockade.Recent findingsCardiotoxicity is a rare but potentially fatal complication associated with novel immunotherapies. Both affinity-enhanced and chimeric antigen receptor T cells have been reported to cause hypotension, arrhythmia, and left ventricular dysfunction, typically in the setting of cytokine release syndrome. Immune checkpoint inhibitors are generally well-tolerated but have the potential to cause myocarditis, with clinical presentations ranging from asymptomatic cardiac biomarker eleva...
Source: Current Oncology Reports - Category: Cancer & Oncology Source Type: research
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