Pancreatic lipase inhibitory and antioxidative constituents from the aerial parts of Paeonia lactiflora Pall. (Ranunculaceae)

Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Odontuya Gendaram, Lai Daowan, Purevdorj Erdenetsogt, Proksch Peter To date, there have been reports mostly about research results of the peony root in comparison to the aerial parts. According to our study, the aerial parts of P.lactiflora showed superior anti-oxidative and pancreatic lipase inhibitory activities than its root. Especially, the water extract and the ethyl acetate fraction of the ethanol extract exhibited potent pancreatic lipase inhibitory activity by 53.11±1.22% and 46.16±1.55% at the same dose of orlistat (62.5±1.27%). The ethanol extract exhibited the best anti-oxidative activity with IC50 of 17.08±0.9μg/mL, and the ethyl acetate fraction 19.75±0.02μg/mL, respectively, comparing to the positive control rutin (IC50, 22.66±0.29μg/mL). From the anti-oxidative and pancreatic lipase inhibitory active fractions three new compounds, monplacphloroside (1), monplachydroxyquinoside (2) and herbacetin-7-O-β-d-sophoroside (3) were isolated along with 19 (4-22) known ones. Compounds, PGG (14), 1-O-methyl-2,3,4,6-tetra-O-galloyl-β-d-glucopyranose (17) and ethylgallate (9) were found to be the strongest antioxidants and pancreatic lipase inhibitors. Monoterpenes, albiflorin R2 (19) and albiflorin (20) were determined for the first time as strong pancreatic lipase inhibitors. The presence of the esterified galloyl moiety, with its increasing numbers or the β-lactone cycl...

Source: Phytochemistry Letters - July 20, 2017 Category: Chemistry Source Type: research