Comment on "The [4Fe4S] cluster of human DNA primase functions as a redox switch using DNA charge transport"

O’Brien et al. (Research Article, 24 February 2017, eaag1789) proposed a novel mechanism of primase function based on redox activity of the iron-sulfur cluster buried inside the C-terminal domain of the large primase subunit (p58C). Serious problems in the experimental design and data interpretation raise concerns about the validity of the conclusions.

Source: ScienceNOW - July 20, 2017 Category: Science Authors: Baranovskiy, A. G., Babayeva, N. D., Zhang, Y., Blanco, L., Pavlov, Y. I., Tahirov, T. H. Tags: Biochemistry, Online Only t-comment Source Type: news