Bone Health Drug Inhibits Mesothelioma Tumor Growth

A drug used to treat bone disease and high blood calcium levels may carry benefits as part of a combination treatment for malignant pleural mesothelioma, a recent study concluded. Researchers at the University of Alabama at Birmingham Comprehensive Cancer Center conducted a pilot study testing the effects of zoledronic acid — a bisphosphonate, or bone health drug, marketed as Reclast and Zometa — against a small group of patients with unresectable pleural mesothelioma. The study, published in the June edition of Lung Cancer: Targets and Therapy journal, was a follow-up to preclinical research showing zoledronic acid’s antiangiogenic (substances that inhibit growth of new blood vessels) effect on mesothelioma cancer cells in vitro. In the pilot study, zoledronic acid only showed a modest effect as a stand-alone therapy for patients with advanced pleural mesothelioma, with a composite response rate of 12.5 percent and a clinical benefit rate (response and stability of the disease) of 37.5 percent. However, researchers believe the results warrant further investigation of the bone disease drug as a combination therapy for mesothelioma. “Our findings suggest that zoledronic acid has single-agent activity in [malignant pleural mesothelioma] treatment,” lead author Muhammad Omer Jamil wrote in the study. “Zoledronic acid can mitigate angiogenesis at subcellular level by mevalonate pathway inhibition and is beneficial in antitumor therapy.&rdq...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: bone disease treatment keytruda mesothelioma treatments Muhammad Omer Jamil reclast treating malignant pleural mesothelioma University of Alabama at Birmingham Comprehensive Cancer Center Zoledronic acid zometa Source Type: news

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Source: Methods - Category: Molecular Biology Source Type: research
Publication date: Available online 15 June 2019Source: Journal of Molecular LiquidsAuthor(s): Prakash Bansode, Pradnya Patil, Prafulla Choudhari, Manish Bhatia, Apurva Birajdar, Indumathi Somasundaram, Gajanan RashinkarAbstractA novel series of ferrocene tethered ionic liquids (ILs) has been synthesized by quaternization of 1-N-(ferrocenylmethyl)benzimidazole, 1-N-(ferrocenylmethyl)imidazole and 1-N-(ferrocenylmethyl)-1,2,4-triazole with long chain alkyl bromides. The synthesized ILs were screened for their anticancer activity against human breast cancer cell line MCF-7. ILs 2a–d and 4b displayed significant anticanc...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
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Source: Journal of Alloys and Compounds - Category: Chemistry Source Type: research
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Source: CNS Neuroscience and Therapeutics - Category: Neuroscience Authors: Tags: CNS Neurosci Ther Source Type: research
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Source: Progres en Urologie - Category: Urology & Nephrology Tags: Prog Urol Source Type: research
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