Bone Health Drug Inhibits Mesothelioma Tumor Growth

A drug used to treat bone disease and high blood calcium levels may carry benefits as part of a combination treatment for malignant pleural mesothelioma, a recent study concluded. Researchers at the University of Alabama at Birmingham Comprehensive Cancer Center conducted a pilot study testing the effects of zoledronic acid — a bisphosphonate, or bone health drug, marketed as Reclast and Zometa — against a small group of patients with unresectable pleural mesothelioma. The study, published in the June edition of Lung Cancer: Targets and Therapy journal, was a follow-up to preclinical research showing zoledronic acid’s antiangiogenic (substances that inhibit growth of new blood vessels) effect on mesothelioma cancer cells in vitro. In the pilot study, zoledronic acid only showed a modest effect as a stand-alone therapy for patients with advanced pleural mesothelioma, with a composite response rate of 12.5 percent and a clinical benefit rate (response and stability of the disease) of 37.5 percent. However, researchers believe the results warrant further investigation of the bone disease drug as a combination therapy for mesothelioma. “Our findings suggest that zoledronic acid has single-agent activity in [malignant pleural mesothelioma] treatment,” lead author Muhammad Omer Jamil wrote in the study. “Zoledronic acid can mitigate angiogenesis at subcellular level by mevalonate pathway inhibition and is beneficial in antitumor therapy.&rdq...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: bone disease treatment keytruda mesothelioma treatments Muhammad Omer Jamil reclast treating malignant pleural mesothelioma University of Alabama at Birmingham Comprehensive Cancer Center Zoledronic acid zometa Source Type: news

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Publication date: Available online 7 July 2020Source: The American Journal of SurgeryAuthor(s): Kurt S. Schultz, Susanna W.L. de Geus, Teviah E. Sachs, Ryan B. Morgan, Sing Chau Ng, David McAneny, Jennifer F. Tseng
Source: The American Journal of Surgery - Category: Surgery Source Type: research
The objectives of this paper are the presentation of a sample of patients with PC undergoing treatment with androgen deprivation therapy (ADT) in usual clinical practice and the determination of parameters associated with the development of resistance to castration (CRPC). MATERIAL AND METHODS: Multicenter, observational, retrospective study that analyzes patients treated with ADT from January 2016 to January 2017. Descriptive analysis of the most relevant clinical variables and univariante analysis and progression times by Kaplan-Meier test. RESULTS: Sample of 952 patients. At PC diagnosis median age 74 years. Med...
Source: Archivos Espanoles de Urologia - Category: Urology & Nephrology Tags: Arch Esp Urol Source Type: research
CONCLUSIONS: We concluded that despite the fact that the plasmacytoid variant of BC is rare, it is important to take into account the pathologic and clinical features of this tumor in order to manage the optimal treatment of this poor prognosis cancer. PMID: 32633253 [PubMed - in process]
Source: Archivos Espanoles de Urologia - Category: Urology & Nephrology Tags: Arch Esp Urol Source Type: research
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Source: Headlines - Category: Radiology Source Type: news
In this study, we hypothesize that areas of bone marrow with high fat volumes are associated with significant changes in cell number within a similar region of interest (ROI). Inbred albino Louvain (LOU) rats, originating from the Wistar strain, have been described as a model of healthy aging with the absence of obesity but expressing the typical features of age-related bone loss. We compared local changes in distal femur cellularity and structure in specific ROI of undecalcified bone sections from 4- and 20-month-old male and female LOU rats and Wistar controls. Our results confirmed that older LOU rats exhibited signific...
Source: Calcified Tissue International - Category: Orthopaedics Source Type: research
CONCLUSION: To address flaws in conceptualisation and the resulting gaps in knowledge, we suggest a definition and a theoretical framework that are suited to allow heterogeneity in the field, but enables the development of sound interventions, as well as facilitate the interpretation of intervention effectiveness. PMID: 32631110 [PubMed - in process]
Source: European Journal of General Practice - Category: Primary Care Tags: Eur J Gen Pract Source Type: research
Publication date: 30 August 2020Source: International Journal of Pharmaceutics, Volume 586Author(s): Joo Young Lee, Young-um Jo, Heejun Shin, Jonghwan Lee, Soon Uk Chae, Soo Kyung Bae, Kun Na
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
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Source: International Journal of Hyperthermia - Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research
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Source: Annals of Medicine - Category: Internal Medicine Tags: Ann Med Source Type: research
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Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Tags: Rheum Dis Clin North Am Source Type: research
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