Accuray touts study data in head-to-head between TomoTherapy and Varian ’ s RapidArc

Accuray (NSDQ:ARAY) today released data from a prospective study comparing its TomoTherapy intensity-modulated radiation therapy system with Varian Medical‘s (NYSE:VAR), RapidArc radiotherapy system, touting a higher survival rate for patients treated with its TomoTherapy system. Results from the study were published last month in the International Journal of Radiation Oncology – Biology – Physics. Accuray said that the 166-patient, multi-center study was the 1st to prospectively compare clinical outcomes across radiation platforms. In the study, 74 individuals were treated with the TomoTherapy system while 92 were treated with the RapidArc system. Loco-regional control, specific and overall survival were assessed up to 18 months post-treatment, as well as long-term toxicity and salivary function. Results indicated that patients treated with the TomoTherapy system were better, as measured by local control, cancer-specific survival and salivary function at 18 months. The company said that further analysis indicated a greater benefit in local control of larger tumors, and those which have spread to a high number of lymph nodes. “This is the 1st study to assess whether the method of delivering IMRT impacts the results we are able to achieve. In previous studies, we showed that TomoHelical was able to deliver radiation dose distributions which precisely conformed to the shape of the tumor with steep radiation fall-off outside the target. In this...
Source: Mass Device - Category: Medical Devices Authors: Tags: Clinical Trials Oncology Accuray Inc. Varian Medical Systems Source Type: news

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CONCLUSION: Once weekly low dose cisplatin treatment showed lower acute toxicity and a better compliance compared to once every 3 weeks high dose cisplatin treatment at the expense of a lower loco-regional control. PMID: 32212810 [PubMed - in process]
Source: Asian Pacific Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research
Conclusions: At the time of writing of this study, there were more than 12,000 medical linear accelerators in clinical use, and XMLC can prove itself useful wherever linac is equipped with MLC but cannot delivery latest techniques, such as volumetric modulated arc therapy.
Source: Journal of Medical Physics - Category: Physics Authors: Source Type: research
Intensity-modulated radiation therapy (IMRT) administered by high-volume radiation oncologists (ROs) provides a survival benefit for patients with head and neck cancers (HNC) compared to treatment by low-volume ROs. However, geographic proximity is often a factor in choosing providers. Additional costs can be associated with relocating to a higher-volume center, but may be worthwhile with respect to treatment outcomes. Our objective was to determine the cost-effectiveness of IMRT by low- versus high-volume ROs for patients with HNC.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Toxicity, Quality of Life, Survivorship, Costs of Care Source Type: research
Definitive radiation remains a treatment option for early stage glottic larynx cancer. Intensity modulated radiation therapy (IMRT) has been the standard treatment for more advanced head and neck cancers, while 3D conformal radiotherapy (3D CRT) has remained standard for early glottic cancers. We used the National Cancer Database (NCDB) to identify predictors of IMRT use and effect on outcome in these patients.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Definitive Management of Head and Neck Squamous Cell Carcinoma Source Type: research
This study aimed to compare the efficacy of radiotherapy planning techniques in reducing lung irradiation while retaining target coverage. Among all HNC patients with mediastinal involvement who underwent radiotherapy between 2007 and 2014 at our hospital, seven consecutive patients were included in this study. Four different treatment plans were generated for each patient as follows: seven-field intensity-modulated radiation therapy (IMRT), modified IMRT in which the lateral beams avoided the lungs, three-full-arc volumetric-modulated arc therapy (VMAT), and VMAT with lung avoidance. We compared the outcomes of IMRT and V...
Source: Radiological Physics and Technology - Category: Physics Source Type: research
Intensity modulated radiation therapy (IMRT), including volumetric modulated arc therapy (VMAT), has become extensively used to treat cancer patients. However, the known benefits [1,2] come along with an increased potential for errors. Recognizing the effectiveness of dosimetry audits in identifying discrepancies and reducing uncertainties, the International Atomic Energy Agency (IAEA) developed an ‘end-to-end’ audit program to review the physics aspects of Head and Neck (H&N) IMRT/VMAT treatments through on-site visits.
Source: Physica Medica: European Journal of Medical Physics - Category: General Medicine Authors: Tags: Original paper Source Type: research
Abstract Positron emission tomography (PET) with 18F-fluordeoxyglucose (FDG) in combination with computed tomography (CT) is well established for the diagnostic work-up of patients with head and neck cancer. Possible applications include the detection of an occult primary tumor metastatic to cervical nodes, locoregional staging, assessment of treatment response to external beam irradiation (also in combination with chemotherapy), and surveillance for recurrence. The success of high-precision irradiation techniques such as intensity-modulated radiation therapy (IMRT) appears to be improved by delineating the tumor ...
Source: Nuklearmedizin - Category: Radiology Authors: Tags: Laryngorhinootologie Source Type: research
Publication date: January 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 129, Issue 1Author(s): Dalal Alhajji, Yoon Ah Danskin, Bridget O'hara, Karl Armand Solano, Jessica Flynn, Elyn Riedel, Sae Hee Kim Yom, Cherry EstiloObjectivesOsteoradionecrosis (ORN) is a complication of head and neck radiation therapy (RT) and is associated with significant morbidity. The incidence of ORN is variable, and it has been speculated to be lower with advanced RT techniques. Risk factors that have been associated with the development of ORN mainly include trauma and a radiation dose to the head and neck ...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
Osteoradionecrosis (ORN) is a complication of head and neck radiation therapy (RT) and is associated with significant morbidity. The incidence of ORN is variable, and it has been speculated to be lower with advanced RT techniques. Risk factors that have been associated with the development of ORN mainly include trauma and a radiation dose to the head and neck region greater than 60 Gy. However, in a study conducted by our group, ORN developed spontaneously (without any known history of trauma or dentoalveolar procedure) in 82% of the ORN cohort following intensity-modulated radiation therapy (IMRT).The purpose of this stud...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Source Type: research
Publication date: November–December 2019Source: Reports of Practical Oncology &Radiotherapy, Volume 24, Issue 6Author(s): Ram Abhinav Kannan, TR Arul PonniAbstractAimTo analyse the long term swallowing function in head and neck cancer patients and correlate with the dose to midline swallowing structures.BackgroundThe use of concurrent chemo radiation (CRT) as the present standard of care resulted in high rates of early and late toxicities. Dysphagia, aspiration, and xerostomia are early as well as late effects of radiation. Not many studies on the dysphagia scores during radiation and follow-up period have correl...
Source: Reports of Practical Oncology and Radiotherapy - Category: Cancer & Oncology Source Type: research
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