Extrafollicular PD1 and Intrafollicular CD3 Expression Are Associated With Survival in Follicular Lymphoma

Conclusion Our study supports the hypothesis that survival in FL depends on the immunologic cross talk between malignant cells and microenvironment; however, the specific types of cells that influence the clinical behavior of FL are still unknown. Micro-Abstract This study aimed to stratify follicular lymphoma (FL) patients' outcome according to immunohistochemical parameters. The study correlated Ki-67, CD68, PD1 and CD3 results with clinical outcome. We found that high extrafollicular PD1 and low intrafollicular CD3 correlated with better outcome. Further studies are necessary in order to understand the complexity of the tumor microenvironment and its association with FL outcome.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research