High-Throughput Analysis of Ovarian Cycle Disruption by Mixtures of Aromatase Inhibitors

Conclusions: These results demonstrate the possibility to predict large-scale mixture effects for endocrine disrupters with a predictive toxicology approach that is suitable for high-throughput ranking and risk assessment. The size of the effects predicted is consistent with an increased risk of infertility in women from everyday exposures to our chemical environment. https://doi.org/10.1289/EHP742 Received: 30 June 2016 Revised: 07 December 2016 Accepted: 24 February 2017 Published: 19 July 2017 Address correspondence to F.Y. Bois, INERIS, DRC/VIVA, Parc ALATA, BP 2, 60550 Verneuil en Halatte, France. Telephone: 33-344-234-385; Email: frederic.bois@ineris.fr Supplemental Material is available online (https://doi.org/10.1289/EHP742). The authors declare they have no actual or potential competing financial interests. Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehponline@niehs.nih.gov. Our staff will work with you to assess and meet your accessibility needs within 3 working days. Supplemental Material PDF (2 MB) Note to readers with disabilities: EHP has provided a 508-conformant table of contents summarizing the Supplemental Mater...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research

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