Researchers Grow Functioning Liver Tissue in Mice

WEDNESDAY, July 19, 2017 -- Researchers say they were able to coax tiny " seeds " of liver tissue into fully functioning livers in mice. If this approach works in people, it could help reduce long wait lists for liver transplants. It might also...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news

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AbstractBackgroundAcute kidney injury in the setting of alcoholic liver disease portends a poor prognosis without liver transplant.AimsUsing a tertiary care population, we aimed to evaluate the outcomes of renal replacement therapy in patients with alcoholic liver disease and acute kidney injury with  
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
I read with great interest the review article published recently by Mindikoglu et  al1 and would like to congratulate the authors on their eloquent update on hepatorenal syndrome (HRS). As pointed out distinctly, HRS continues to be a significant problem faced by clinicians who are actively involved in managing patients with advanced liver disease with ascites. HRS type 1 is a t ype of rapidly progressive acute kidney injury and is associated with a median survival of only approximately 4 weeks. It thus becomes extremely crucial to predict the subset of patients who are likely to be nonresponsive to vasoconstrictor th...
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research
Authors: Yu YB, Song Y, Chen Y, Zhang F, Qi FZ Abstract Mesenchymal stem cells (MSCs) are considered to be an ideal source for the cell therapy of end‑stage liver diseases. Umbilical cord (UC)‑MSCs can be obtained via a non‑invasive procedure and can be easily cultured, making them potentially superior candidates for cell transplantation when compared with MSCs from other sources. In the present study, UC‑MSCs were induced to differentiate into hepatocytes and were compared with bone marrow (BM)‑MSCs for their hepatic differentiation potential. UC‑MSCs showed significantly higher proliferation than BM...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
International Journal of Dermatology, EarlyView.
Source: International Journal of Dermatology - Category: Dermatology Authors: Source Type: research
Publication date: Available online 20 June 2018 Source:Pharmacological Research Author(s): Alex Evangelista do Amaral, Michele Patrícia Rode, Julia Cisilotto, Telma Erotides da Silva, Josiane Fischer, Camila Matiollo, Elayne Cristina de Morais Rateke, Janaína Luz Narciso-Schiavon, Leonardo Lucca Schiavon, Tânia Beatriz Creczynski-Pasa MicroRNAs (miRNAs) have remarkable potential as diagnostic and prognostic markers because of their roles in disease pathogenesis. miRNAs can be released into the bloodstream, where they are sufficiently stable to be detected noninvasively. Here, we prospectively evaluated...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
AbstractPurpose of ReviewTo highlight the current trends of weight loss supplement (WLS) use in the United States, detail their potential for drug-induced liver injury (DILI), identify specific compounds associated with hepatoxicity that are commonly found in WLS, and address ongoing diagnostic as well as treatment challenges.Recent FindingsThe regulatory nature of WLS exposes patients to a variety of potential healthcare pitfalls associated with WLS use. These include marketing claims with little supportive evidence, compound adulteration, and herb-drug interactions. While well-known historical cases have resulted in spec...
Source: Current Hepatitis Reports - Category: Infectious Diseases Source Type: research
Clinical Transplantation, EarlyView.
Source: Clinical Transplantation - Category: Transplant Surgery Authors: Source Type: research
ConclusionsHealthy donor FMT for SAH improves survival beyond what is offered by current therapies and can function as a cost-effective bridge to liver transplant (LT) or for improving transplant-free survival. Larger studies and randomized trials are unmet needs.
Source: Indian Journal of Gastroenterology - Category: Gastroenterology Source Type: research
Condition:   Liver Disease Intervention:   Sponsor:   Medical University of South Carolina Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Biliary Atresia Intrahepatic Syndromic Form Interventions:   Drug: Lactated Ringer;   Drug: Normal saline Sponsor:   RenJi Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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