Comparison of the Systemic and Local Pharmacokinetics of Clonidine Mucoadhesive Buccal Tablets with Reference Clonidine Oral Tablets in Healthy Volunteers: An Open-Label Randomised Cross-Over Trial

ConclusionClonidine MBT is well tolerated and exhibits proportional saliva and plasma PK over the 50 –100-µg dose level. The MBT results in higher saliva concentrations and lower systemic exposure than OT, which was associated with a trend towards fewer adverse events and less dry mouth, fatigue and hypotensive effect.FundingOnxeo SA.Trial RegistrationClinicalTrials.gov identifier, NCT02548806.
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research