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Engineered liver tissue expands after transplant

(Massachusetts Institute of Technology) Researchers have developed a way to engineer liver tissue by organizing tiny subunits that contain cells embedded into a biodegradable tissue scaffold. In a study of mice with damaged livers, the researchers from MIT, Rockefeller University, and Boston University found that after implantation in the abdomen, the structures expanded 50-fold and performed normal liver tissue functions.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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Abstract The term 'economy class syndrome' refers to the occurrence of thrombotic events during long-haul flights that mainly occur in passengers in the economy class of the aircraft. This syndrome results from several factors related to the aircraft cabin (immobilization, hypobaric hypoxia and low humidity) and the passenger (body mass index, thrombophilia, oral contraceptives or hormone replacement therapy, cancer), acting together to predispose to excessive blood coagulation, which can result in venous thromboembolism. Several risk factors, both genetic and acquired, are associated with venous thromboembolism. The most ...
Source: Revista Brasileira de Hematologia e Hemoterapia - Category: Hematology Source Type: research
Authors: Gholson CF, McDonald J, McMillan R Abstract Preview How many months of documented abstinence are required before a patient with alcoholic cirrhosis can be considered for liver transplantation? What is the role of liver transplantation as treatment for primary hepatocellular cancer? What are the possible causes of elevated liver enzyme levels following transplantation? Which patients with neurologic injury are potential organ donors? The authors answer these and other questions primary care physicians may have about this lifesaving procedure. PMID: 29219713 [PubMed]
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
In conclusion, the arguments supporting moderately loosened criteria for cancer seem more valid today than in the past. Transplant oncology is likely to represent a leading field in the near future, also because comorbidities and transplant‐related causes of death are better managed and often eliminated. Liver Transplantation 2017 AASLD.
Source: Liver Transplantation - Category: Transplant Surgery Authors: Tags: Controversies in Liver Transplantation Source Type: research
Conclusion: Whole-exome sequencing identified diagnostic mutations in a substantial number of adults with CKD of many causes. Further study of the utility of WES in the evaluation and care of patients with CKD in additional settings is warranted. Primary Funding Source: New York State Empire Clinical Research Investigator Program, Renal Research Institute, and National Human Genome Research Institute of the National Institutes of Health. PMID: 29204651 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - Category: Internal Medicine Authors: Tags: Ann Intern Med Source Type: research
Miki Lustig, PhD, associate professor of electrical engineering and computer science at University of California Berkeley wanted to make MRI coils less heavy and cumbersome for child patients. Ana Claudia Arias, PhD, a physicist in the same department was creating printed wearable devices made of liquid nanoparticles. Although Arias didn ’t know anything about MRI and Lustig had no experience building hardware, the two combined forged to develop lightweight plastic MRI coils. There has been a lack of advancement in imaging technology for children patients. Arias and Lustig worked with Shreyas Vasanawala, MD, a pediat...
Source: radRounds - Category: Radiology Authors: Source Type: blogs
ConclusionRBV‐free DAA‐combinations for the treatment of HCV‐recurrence after OLT are highly efficacious and well tolerated. Our long‐term data show that viral eradication is durable but not necessarily translated into beneficial long‐term clinical outcome.This article is protected by copyright. All rights reserved.
Source: Liver International - Category: Gastroenterology Authors: Tags: Original Article Source Type: research
Abstract Background &AimsThe outcome of compensated cirrhosis may vary considerably and cannot be predicted by routinely performed tests at present. Aim of this study was to evaluate possible predictors of clinical evolution in patients with Child‐Pugh (C‐P) class A cirrhosis due to untreatable causes by analysing clinical/biochemical/instrumental parameters evaluated at the time of diagnosis and during the subsequent long‐lasting follow‐up. MethodsTwo‐hundred‐seventy‐two consecutive C‐P class A cirrhotic patients (155 males; median age 63 years, range 34‐81) were analysed. All patients were followed...
Source: Liver International - Category: Gastroenterology Authors: Tags: Original Article Source Type: research
CONCLUSIONS: The median survival time for all patients was 106 months. The 5- and 10-year observed survival rates were 61 and 43%, respectively. The observed cumulative 5- and 10-year recurrence rates were 37 and 39%, respectively, 10-year intrahepatic and extrahepatic recurrence rates were 12 and 27%, respectively. Median survival time after diagnosis of first recurrence was 7.5 (0-120) months; 2 and 18 months for all, intra- and extrahepatic recurrence, respectively. UCSF-, up to seven-, Shanghai Fudan- or Duvoux classifications can identify patients with a cumulative 10-year recurrence rate below 20%. The pre-...
Source: Clin Med Res - Category: Research Authors: Tags: J Cancer Res Clin Oncol Source Type: research
In conclusion, IR-induced PARP-1 up-regulation increased the hepatic recruitment of neutrophils through regulation of CXCL1/CXCR2 signaling and polarized hepatic neutrophils to proangiogenic phenotype, which further promoted HCC recurrence after transplantation. PMID: 29179487 [PubMed]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
We examined associations between mortality and accelerometer-measured PA using age-relevant intensity cutpoints in older women of various ethnicities. The results support the hypothesis that higher levels of accelerometer-measured PA, even when below the moderate-intensity threshold recommended in current guidelines, are associated with lower all-cause and CVD mortality in women aged 63 to 99. Our findings expand on previous studies showing that higher self-reported PA reduces mortality in adults aged 60 and older, specifically in older women, and at less than recommended amounts. Moreover, our findings challenge th...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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