Log in to search using one of your social media accounts:

 

Engineered liver tissue expands after transplant

(Massachusetts Institute of Technology) Researchers have developed a way to engineer liver tissue by organizing tiny subunits that contain cells embedded into a biodegradable tissue scaffold. In a study of mice with damaged livers, the researchers from MIT, Rockefeller University, and Boston University found that after implantation in the abdomen, the structures expanded 50-fold and performed normal liver tissue functions.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

Related Links:

Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Making human tissue in a lab has always been more sci-fi than sci-fact, but powerful genetic technologies may change that soon. For the most part, the only way to replace diseased or failing hearts, lungs, kidneys and livers is with donor organs. Even then, many people struggle to find a good biological match with a donor, and 8,000 die each year in the U.S. while waiting for an organ. In one promising solution to the shortage, researchers have been putting a new DNA editing tool called CRISPR through rigorous tests in organ regeneration. Last August, a group of scientists led by George Church, professor of genetics at Har...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime Longevity organ transplants Source Type: news
AbstractObjectivesThe aim of this study was to analyze the prevalence of mental disorders in patients undergoing liver transplantation (LT) based on claims data from the Health Insurance Review and Assessment Service (HIRA) in South Korea.MethodsWe confirmed mental disorders in a nationwide cohort of 3758 patients receiving LT between January 2010 and December 2014. We categorized the prevalence of mental disorders based on patient age at the time of LT.ResultsA total of 288 patients for LT were diagnosed with a mental disorder 1  year before their cancer diagnosis. Of those patients, depression was present in 90 (31....
Source: Hepatology International - Category: Infectious Diseases Source Type: research
In conclusion, most experimental data on immune changes with aging show a decline in many immune parameters when compared to young healthy subjects. The bulk of these changes is termed immunosenescence. Immunosenescence has been considered for some time as detrimental because it often leads to subclinical accumulation of pro-inflammatory factors and inflammaging. Together, immunosenescence and inflammaging are suggested to stand at the origin of most of the diseases of the elderly, such as infections, cancer, autoimmune disorders, and chronic inflammatory diseases. However, an increasing number of gerontologists have chall...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
rmani Hepatocellular carcinoma is one of the main important causes of cancer-related death and its mortality is increasingly worldwide. In Europe, alcohol abuse accounts for approximately half of all liver cancer cases and it will become the leading cause of hepatocellular carcinoma in the next future with the sharp decline of chronic viral hepatitis. The pathophysiology of alcohol-induced carcinogenesis involves acetaldehyde catabolism, oxidative stress and chronic liver inflammation. Genetic background plays also a significant role and specific patterns of gene mutations in alcohol-related hepatocellular carcinoma ha...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Opinion statementSecond malignancies are a rare but well-defined late complication after autologous and allogeneic hematopoietic stem-cell transplantation (SCT). Solid malignancies occur in up to 15% of patients 15  years after SCT with myeloablative conditioning, with no plateau in the incidence rates. They are responsible for 5–10% of late deaths after SCT. The incidence is increased with advanced age at SCT. The major risk factors are the use of total body irradiation, which is associated with adenocarci nomas and with chronic graft-versus-host disease which is associated with squamous cell cancers. There is ...
Source: Current Treatment Options in Oncology - Category: Cancer & Oncology Source Type: research
Authors: Ekinci O, Baran B, Ormeci AC, Soyer OM, Gokturk S, Evirgen S, Poyanli A, Gulluoglu M, Akyuz F, Karaca C, Demir K, Besisik F, Kaymakoglu S Abstract AIM: To investigate clinical, etiological, and prognostic features in patients with hepatocellular carcinoma. METHODS: Patients with hepatocellular carcinoma who were followed-up from 2001 to 2011 were included in the study. The diagnosis was established by histopathological and/or radiological criteria. We retrospectively reviewed clinical and laboratory data, etiology of primary liver disease, imaging characteristics and treatments. Child-Pugh and Barcelon...
Source: World Journal of Hepatology - Category: Gastroenterology Tags: World J Hepatol Source Type: research
This study investigates the outcomes after intestine/multivisceral re-transplantation. MATERIAL AND METHODS Clinical outcomes of 23 patients undergoing 24 re-transplantations at a single intestine transplant center were reviewed. Bone marrow suppression was used as a surrogate marker of immunocompromised status, and was defined as platelet count
Source: Annals of Transplantation - Category: Transplant Surgery Authors: Tags: Ann Transplant Source Type: research
Liver transplantation (LT) is regarded as the best option for radical treatment in patients with very early (stage 0) or early (stage A) hepatocellular carcinoma (HCC), according to the Barcelona Clinic Liver Cancer guideline.[1 –3] Careful patient selection is important in reducing the tumor recurrence rate and maximizing the effectiveness of LT for HCC because the availability of deceased and living donor organs is limited. Thus, the Milan criteria are used as the gold standard to increase the post-transplant survival r ate of patients with HCC, with a 5-year survival rate of 70% after LT and a recurrence rate of less than 20%.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research
Abstract BACKGROUND AND AIM OF THE WORK: Hepatocellular carcinoma (HCC) is the most frequent primary liver malignancy. Chronic liver injuries as chronic hepatitis C and hepatitis B viruses, aflatoxins consumption and nonalcoholic fatty liver disease are well-established causes of HCC. HCC is associated with a series of molecular changes, as alternation in glypican-3, P53 expression and Wnt/β-catenin pathway. Hepatic cancer progenitor cells could contribute to HCC development. This research aimed to study the effectiveness of human CD34+ hematopoietic stem cell on Wnt4 and P53 genes expression, histopathologic...
Source: Tissue and Cell - Category: Cytology Authors: Tags: Tissue Cell Source Type: research
More News: Boston University | Cancer | Cancer & Oncology | Liver | Liver Transplant | Study | Transplant Surgery | Transplants | Urology & Nephrology