Engineered liver tissue expands after transplant

(Massachusetts Institute of Technology) Researchers have developed a way to engineer liver tissue by organizing tiny subunits that contain cells embedded into a biodegradable tissue scaffold. In a study of mice with damaged livers, the researchers from MIT, Rockefeller University, and Boston University found that after implantation in the abdomen, the structures expanded 50-fold and performed normal liver tissue functions.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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Backgrounds: Regarding the difficulty of CHC diagnosis and potential adverse outcomes or misuse of clinical therapies, an increasing number of patients have undergone liver transplantation, transcatheter arterial chemoembolization (TACE) or other treatments.Objective: To construct a convenient and reliable risk prediction model for identifying high-risk individuals with combined hepatocellular-cholangiocarcinoma (CHC).Methods: 3369 patients who underwent surgical resection for liver cancer at Zhongshan Hospital were enrolled in this study. The epidemiological and clinical characteristics of the patients were collected at t...
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research
Introduction: De novo malignancy is a major cause of long term morbidity and mortality in patients after liver transplantation (LTx). The overall risk is estimated to be 2-4 times higher as compared to general population. Neither cancer screening protocols, nor universal recommendations have yet been established. The aim of this study was to evaluate incidence of de novo malignancies, identify potential risk factors and characterise the overall outcome of patients after LTx.
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
CONCLUSIONS: Liver transplant is a curative therapy for selected patients with irresectable Klatskin tumors, but further prospective studies are urgently needed. PMID: 29911960 [PubMed - as supplied by publisher]
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - Category: Transplant Surgery Authors: Tags: Exp Clin Transplant Source Type: research
Conclusion The ability of 18F-FDG PET/CT to detect extrahepatic disease before LT for NCLM is vital to establish LT as a treatment option.
Source: Nuclear Medicine Communications - Category: Nuclear Medicine Tags: Original Articles Source Type: research
Hepatocellular carcinoma (HCC) is a very aggressive disease and represents the third leading cause of cancer-related mortality worldwide [1]. Although treatment of HCC has greatly improved over the last decade, most HCC patients are presented with an underlying chronic liver disease and diagnosed only at advanced stages, when they are no longer eligible for curative therapies such as liver resection or transplantation [2]. In these cases, the multi-target tyrosine kinase inhibitor sorafenib is the only FDA-approved first-line systematic therapy, expanding patient median survival from 7.9 to 10.7 months [3 –5].
Source: Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research
CONCLUSION: Irrespective of new developments in treatment strategies for metastasized colorectal cancer, resection of colorectal liver metastases remains the gold standard whenever possible. PMID: 29872867 [PubMed - as supplied by publisher]
Source: Der Chirurg - Category: Surgery Authors: Tags: Chirurg Source Type: research
Conclusion Post-transplant NAFLD represented a strong risk factor for cardiovascular atherosclerotic disease and solid extrahepatic cancer, whereas de novo histologically proven NASH was an independent predictor of long-term mortality.
Source: European Journal of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Liver resection surgeries are common procedures performed to remove a variety of cysts and cancers, intrinsic as well as metastatic. Liver resections are also done for transplantation purposes. Dangers lurk when removing parts of the liver because th...
Source: Medgadget - Category: Medical Devices Authors: Tags: Informatics Radiology Surgery Source Type: blogs
This study indicates that frailty and other age-related diseases could be prevented and significantly reduced in older adults. Getting our heart risk factors under control could lead to much healthier old ages. Unfortunately, the current obesity epidemic is moving the older population in the wrong direction, however our study underlines how even small reductions in risk are worthwhile." The study analysed data from more than 421,000 people aged 60-69 in both GP medical records and in the UK Biobank research study. Participants were followed up over ten years. The researchers analysed six factors that could impa...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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