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CU Boulder discovery could lead to better results for patients undergoing radiation

(University of Colorado at Boulder) A new study involving CU Boulder shows why some cells treated with radiation therapy for cancer leak chemical signals and damage unexposed healthy cells, findings that could lead to new medications that patients could take prior to radiation.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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CONCLUSIONS: Treatment with surgery, IORT, and EBRT is feasible and resulted in good LC and OS, with acceptable morbidity in this unfavorable patient cohort. Incomplete resection and recurrent status resulted in clearly inferior outcomes. Reasonable efforts should be made during primary treatment to prevent the onset of a local recurrence. PMID: 29353660 [PubMed - in process]
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Int J Radiat Oncol Biol Phys Source Type: research
CONCLUSIONS: The incorporation of imaging findings and biological markers into NTCP modeling of liver toxicity improved the estimates of expected NTCP risk compared with using dose-only models. In addition, such generalized NTCP models should contribute to a better understanding of the normal tissue response in HCC SBRT patients and facilitate personalized treatment. PMID: 29353652 [PubMed - in process]
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Int J Radiat Oncol Biol Phys Source Type: research
Brain tumors are common, requiring general medical providers to have a basic understanding of their diagnosis and management. The most prevalent brain tumors are intracranial metastases from systemic cancers, meningiomas, and gliomas, specifically, glioblastoma. Central nervous system metastases may occur anywhere along the neuroaxis, and require complex multidisciplinary care with neurosurgery, radiation oncology, and medical oncology. Meningiomas are tumors of the meninges, mostly benign and often managed by surgical resection, with radiation therapy and chemotherapy reserved for high-risk or refractory disease.
Source: The American Journal of Medicine - Category: General Medicine Authors: Tags: Review Source Type: research
Among a prospectively followed cohort of 471 men treated with radiation therapy for prostate cancer, we demonstrate that sexual aid use is common at baseline, increases with time, and is helpful to many. However, a substantial number of men reported benefit, but were not currently using aids, and future study is required to optimize post-treatment sexual function.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Clinical Investigation Source Type: research
Is decreased survival from radiation therapy to adjacent lung tissue caused by toxicity, or is it due to'unintended consequences'?Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news
In this study, we present the first results and complications rate of patients treated by IORT in a single French institution. Between 2012 and 2015, all patients with breast cancer treated in a one‐step procedure associating lumpectomy and IORT were retrospectively included in a monocentric cohort. Acute and long‐term toxicities were evaluated using CTCAE v4.0 classification. 280 breast cancers were treated using IORT procedure. Additional external beam radiation therapy was requested for 45.7% patients. The acute complications rate was 14.6%, with 5 surgical revisions needed (1.78%). With a median follow up of 911 da...
Source: The Breast Journal - Category: Cancer & Oncology Authors: Tags: ORIGINAL ARTICLE Source Type: research
The objective of this study was to characterize the clinicopathological prognostic factors and treatment patterns for small cell carcinoma (SCC) of the colon, a rare disease without standard treatment guidelines.MethodsWe analyzed clinicopathological and treatment variables for 503 cases of histologically proven SCC colon entered into the National Cancer Database (NCDB) between 2004 and 2013. Survival curves were generated using Kaplan-Meier and compared by the log-rank test. Cox proportional hazard regression was used to control for covariates and evaluate the effect of different treatment modalities on overall survival.R...
Source: Journal of Gastrointestinal Cancer - Category: Cancer & Oncology Source Type: research
To identify optimization of dose distributions of target volumes and decrease of radiation doses to normal tissues during stereotactic body radiation therapy (SBRT) for pancreatic cancer with dose-limiting aut...
Source: Radiation Oncology - Category: Cancer & Oncology Authors: Tags: Research Source Type: research
Owing to its superior soft-tissue visualization, magnetic resonance imaging (MRI) has increasingly been integrated into routine radiation oncology practice, playing a critical role in the diagnosis, staging, and treatment of cancer. For radiation therapy (RT) specifically, the successful delivery of modern image-guided precision techniques demands imaging modalities with both high contrast and high geometric fidelity to visualize the target volume and adjacent organs at risk in hopes of improving the therapeutic ratio.
Source: Journal of Medical Imaging and Radiation Sciences - Category: Radiology Authors: Tags: Commentary Source Type: research
Background and ObjectivesPrimary liver sarcomas (PLS) are rare. Published series are limited by small numbers of patients. MethodsWe reviewed the National Cancer Database (2004‐2014) for patients who underwent surgical resection of PLS. ResultsOf 237 patients identified, the majority were female (60.8%), with median age of 52 years. Histologies were: epithelioid hemangioendothelioma (n = 67), angiosarcoma (n = 64), leiomyosarcoma (n = 33), embryonal rhabdomyosarcoma (n = 31), carcinosarcoma (n = 16), giant cell sarcoma (n = 14), spindle c...
Source: Journal of Surgical Oncology - Category: Cancer & Oncology Authors: Tags: RESEARCH ARTICLE Source Type: research
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