CU Boulder discovery could lead to better results for patients undergoing radiation

(University of Colorado at Boulder) A new study involving CU Boulder shows why some cells treated with radiation therapy for cancer leak chemical signals and damage unexposed healthy cells, findings that could lead to new medications that patients could take prior to radiation.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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Prostate cancer patients may live longer if treated with a combination of surgical removal of the organ and radiation therapy, according to a study.
Source: Health News - - Category: Consumer Health News Source Type: news
Authors: Mignard X, Antoine M, Moro-Sibilot D, Dayen C, Mennecier B, Gervais R, Amour E, Milleron B, Morin F, Zalcman G, Wislez M Abstract BACKGROUND: Programmed cell death-ligand 1 (PD-L1) is a checkpoint receptor that facilitates immune evasion by tumor cells, through interaction with programmed cell death-1 (PD-1), a receptor expressed by T-cells. Durvalumab is an anti-PD-L1 monoclonal antibody that blocks PD-L1 interaction with PD-1 on T-cells, countering the tumor's immune-evading tactics. Phase I/II studies demonstrated durable responses and manageable tolerability in heavily pre-treated patients with non-sma...
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research
Authors: Kretschmer L, Hellriegel S, Thoms KM, Schon MP, Al Ghazal P, Zapf A Abstract Lymphedema (LE) following lymph node dissection is a major problem for cancer patients, and radiation therapy, extended surgery, groin dissection, obesity, and older age are well-established risk factors of LE. We studied whether these risk factors are further associated with high volumes of postoperative drainage fluid after complete lymph node dissection (CLND) for melanoma metastases. Moreover, we examined whether a high amount of drainage fluid after sentinel lymph node biopsy (SLNB) can predict a high amount of drainage fluid...
Source: Lymphology - Category: Internal Medicine Tags: Lymphology Source Type: research
This article is protected by copyright. All rights reserved. PMID: 30244481 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research
ConclusionsIn the present cohort, SBRT to the CL-HCC produced excellent treatment response with acceptable HBT and LC. Select HCC patients who are not candidates for surgery or other locoregional therapies can be considered for SBRT to the central liver.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
Authors: Li J, Zhang L, Xie Q, Wang W, Hua Y, Sun Z Abstract Purpose: To evaluate the efficacies of 125I seed implantation and stereotactic body radiation therapy (SBRT) in treatment of recurrent lung metastases from colorectal cancer, to compare the tolerance of lung tissue to both forms of radiotherapy, and to analyze the factors that affect the prognosis. Material and methods: According to treatment received, thirty colorectal cancer patients with post-operative lung metastases were separated into two groups: 125I seed implantation group (group A; n = 16) and SBRT group (group B; n = 14). Patients were follo...
Source: Journal of Contemporary Brachytherapy - Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research
Authors: Zimmermann JS, Osieka R, Bruns T, Hollberg H, Wiechmann B, Netzbandt O, Sablotny J, Malade M, Heitz M, Bernhardt F, Tiemann J, Wilkens M, Brüske T, Welker U, Heinemann V, Zimmermann P, de la Maza SF, Pfeiffer D, Tauber PR, Thomas D, Moustakis C Abstract Purpose: To assess the effectiveness of low-dose-rate (LDR) brachytherapy in patients with localized prostate cancer and to compare the outcome with predictions from Kattan and Partin nomograms at 60 months after seed implantation. Material and methods: One thousand, one hundred and eighty-seven patients with localized prostate cancer at low-, inte...
Source: Journal of Contemporary Brachytherapy - Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research
ConclusionsOur surveys found that the majority of patients and providers would be willing to participate in a trial of RPLND as an alternative treatment strategy for low-volume, CSII testicular seminoma.
Source: Urology Practice - Category: Urology & Nephrology Source Type: research
The objective of this study was to identify factors influencing the probability of local control. Methods: Ninety-five patients (100 lung tumors) treated between January and December 2013 at our department by SBRT (stereotactic body radiation therapy) using CyberKnife® were included in the study. There were 71 stage T1 or T2 primary tumors and 29 secondary tumors. The tracking methods were as follow: fiducial markers with Synchrony® in 50 cases (gold seeds in 35, coils in 15 cases), spine with 4D-CT and Xsight® Spine in 43 cases, and direct viewing by Xsight® Lung in 7 cases. The methods were allocated ...
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
CONCLUSIONS: This study establishes normative data for a model exploiting dogs with naturally occurring glioma, which can be used to test novel therapies prior to translation to human trials. Further work will focus on the effects of different therapies, including chemotherapy, radiation therapy, and immunotherapy. PMID: 30234401 [PubMed - as supplied by publisher]
Source: Cancer Investigation - Category: Cancer & Oncology Tags: Cancer Invest Source Type: research
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