CU Boulder discovery could lead to better results for patients undergoing radiation
(University of Colorado at Boulder) A new study involving CU Boulder shows why some cells treated with radiation therapy for cancer leak chemical signals and damage unexposed healthy cells, findings that could lead to new medications that patients could take prior to radiation.
Participating in a yoga program while undergoing radiation therapy improved physical functioning and mental in NSCLC patients, and improved vitality in caregivers.Medscape Medical News
Condition: Prostate Intervention: Other: Educational Intervention Sponsor: Sidney Kimmel Cancer Center at Thomas Jefferson University Terminated
Abstract Radiation therapy, a major method of treatment for brain cancer, may cause severe brain injuries after many years. We used a rare and unique cohort of nasopharyngeal carcinoma patients with normal‐appearing brains to study possible early irradiation injury in its presymptomatic phase before severe, irreversible necrosis happens. The aim is to detect any structural or functional imaging biomarker that is sensitive to early irradiation injury, and to understand the recovery and progression of irradiation injury that can shed light on outcome prediction for early clinical intervention. We found an acute increase in...
This report demonstrates that although cases of esophageal adenocarcinoma that present as brain metastases typically carry a poor prognosis, with early and aggressive treatment patients can survive well past one year after diagnosis.Case Rep Oncol 2017;10:938 –944
In conclusion, the results of the present study generated an output of the genome alterations in lung adenocarcinoma, and provided a foundation for further investigation of the pathogenesis of lung adenocarcinoma. PMID: 29039585 [PubMed - as supplied by publisher]
PET scanning plays key roles in planning the management of patients with lung cancer who are candidates for curative-intent treatment with radiotherapy and has contributed to improvements in survival. 18F-fluorodeoxyglucose –PET is the most important modality for staging, patient selection, and radiotherapy target volume definition in patients with unresectable non–small cell lung cancer. Developments include the availability of alternative tracers, such as 18F-fluorothymidine, for imaging proliferation and a range of hypoxia imaging agents. The role of response-adapted therapy, based on interim PET scans perfo...
CONCLUSIONS: Our results suggest advanced age, administration of AC/AP agents, and severe internal iliac artery calcification to be risk factors for LRD in patients undergoing standard RT. Therefore, it is necessary to administer radiation with particular caution in the very elderly, especially those receiving AC/AP agents and/or with severe internal iliac artery calcification. PMID: 29052565 [PubMed - in process]
ConclusionIncreased delay to surgery could affect the BCR, as there was a positive association in high-risk group. Further studies with longer follow-up are necessary to assess the impact of wait time on BCR, cancer specific survival and overall survival.
BACKGROUNDThere is increasing evidence that radiation therapy (RT) can be omitted for select older patients who are compliant with hormonal blockade, but there is no recent claim‐based analysis for determining patterns of care and guiding possible treatment recommendations. METHODSMedicare beneficiaries who were 65 years old or older and were diagnosed with breast cancer at 1 of 12 cancer centers affiliated with an academic center in the southeastern United States were analyzed. Stage 0 or I patients treated with lumpectomy from 2012 to 2014 were identified. Patient, treatment, and center characteristics were analyzed fo...
We report on a 52-year-old woman with cardiomyopathy following chemotherapy and radiation therapy. The patient did not respond well to b-blockers and angiotensin-converting enzyme inhibitors. After the addition of exogenous phosphocreatine, the patient's cardiac condition improved significantly. PMID: 29038417 [PubMed - in process]