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Oldest case of gigantism? Assessment of the alleged remains of Sa-Nakht, king of ancient Egypt

Publication date: August 2017 Source:The Lancet Diabetes & Endocrinology, Volume 5, Issue 8 Author(s): Francesco M Galassi, Maciej Henneberg, Wouter de Herder, Frank Rühli, Michael E Habicht
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research

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Insulin resistance and the development of diabetes mellitus is a common complication of acromegaly. Prevalence of type 2 diabetes in acromegaly varies from 19 to 56% depending on the case series [1]. In acromegaly, high levels of growth hormone and subsequent stimulation of insulin-like growth factor 1 synthesis contribute to peripheral insulin resistance and the development of diabetes [2]. Although absolute insulin levels may be normal or high, the presence of severe insulin resistance may predispose to diabetic ketoacidosis.
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research
CONCLUSIONS: In this article, we summarize the pathophysiology, clinical aspects and the new diagnostic tools to better understand bone impairment in acromegaly. PMID: 28880058 [PubMed - as supplied by publisher]
Source: Minerva Endocrinologica - Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
ConclusionThe validation study underlined IGF-I and tumor status for routine clinical decision-making, whereas patient-oriented outcome measures received less medical attention. An Acromegaly Disease Activity Tool (ACRODAT) is in development that might assist clinicians towards a more holistic approach to patient management in acromegaly.
Source: Pituitary - Category: Endocrinology Source Type: research
AbstractTo analyze the clinical presentation, management and outcomes of patients with pituitary adenoma treated by Endoscopic Endo-nasal Trans-sphenoidal (EETS) excision. Study was conducted on the basis of medical records of 14 patients who had undergone EETS excision of pituitary adenomas. The data obtained was assessed for demographic and clinical characteristics, radiographic features and post-operative outcomes. Study included 10 males and 4 females. Mean age of patients was 46.43  years (range 16–70 Years). Most common presentation was diminished vision reported in 79% patients. Features of acromegaly enc...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - Category: ENT & OMF Source Type: research
CONCLUSIONS Reoperative EEA for acromegaly had results similar to those for first-time surgery and rates of control for macroadenomas that were better than historical rates. Cavernous sinus invasion continues to be a negative prognostic indicator for disease control; however, results with EEA show improvement compared with results reported in the prior literature. PMID: 28862548 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - Category: Neurosurgery Authors: Tags: J Neurosurg Source Type: research
Acromegaly is a rare disorder caused by chronic growth hormone (GH) hypersecretion. While diagnostic and therapeutic methods have advanced, little information exists on trends in acromegaly characteristics over time. The Liège Acromegaly Survey (LAS) Database, a relational database, is designed to assess the profile of acromegaly patients at diagnosis and during long-term follow-up at multiple treatment centers. The following results were obtained at diagnosis. The study population consisted of 3173 acromegaly patients from ten countries; 54.5% were female. Males were significantly younger at diagnosis than females ...
Source: Endocrine-Related Cancer - Category: Endocrinology Authors: Tags: Research Source Type: research
ConclusionsAP102 is a new dual SSTR2/SSTR5-specific somatostatin analog that acutely reduces growth hormone but does not cause hyperglycemia during acute or chronic administration in a healthy rat model. Further studies in diabetic animals and in humans are necessary to determine the potential utility of AP102 in the clinical setting.
Source: Endocrine - Category: Endocrinology Source Type: research
In this study, we examine if the incidence of myocardial infarction (MI) and stroke differ from that of the general population.MethodsData from the German Acromegaly Registry in seven specialized endocrine centres were analysed (n  = 479, 56% female, 46 years old at diagnosis, 5549 person-years from diagnosis). Standardized incidence ratios (SIR) were calculated as compared to the general population.ResultsMI and stroke incidences were very close to those of the general population with an SIR (95% CI) of 0.89 (0.47 –1.52, p = 0.80) for MI and 1.17 (0.66–1.93, p =&thi...
Source: Pituitary - Category: Endocrinology Source Type: research
AbstractPurposeWhether the renin –angiotensin–aldosterone system plays a role or not in the development of cardiovascular morbidity in acromegaly patients is unknown. The aim of the study was to investigate the association between ACE (I/D) and AGT (M235T) gene polymorphisms and cardiovascular and metabolic disorders in the acr omegaly.MethodsThe study included one hundred and seventeen acromegalic patients (62  F/55 M, age: 50.2 ± 12.3 years) and 106 healthy controls (92 F/14 M, age: 41.4 ± 11.3 years). PCR method was used to evaluate the prevalence...
Source: Pituitary - Category: Endocrinology Source Type: research
is a rare, chronic, debilitating condition. Untreated, it causes significant morbidity and reduces life expectancy by about 10 years. The disease process is insidious, and early presenting features can be non-specific (e.g. sweating, fatigue). Physicians, dentists and surgeons should consider this diagnosis if any of the more classically recognized features is present (e.g. dental malocclusion, symptoms of median nerve entrapment, sleep apnoea, type 2 diabetes mellitus without a family history).
Source: Medicine - Category: Internal Medicine Authors: Tags: Pituitary disorders Source Type: research
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