Alkaloids from Cryptocarya densiflora Blume (Lauraceae) and their cholinesterase inhibitory activity

Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Wan Nurul Nazneem Wan Othman, Yasodha Sivasothy, Sook Yee Liew, Jamaludin Mohamad, Mohd Azlan Nafiah, Kartini Ahmad, Marc Litaudon, Khalijah Awang (−)-Desmethylsecoantofine N-oxide (1), a new seco-phenanthroindolizidine alkaloid along with prodensiflorins A and B (2-3), two new proaporphine alkaloids, were isolated from the leaves of Cryptocarya densiflora Blume. Their structures were established on the basis of 1D and 2D NMR techniques and LCMS-IT-TOF analysis. (+)-N-methyllaurotetanine (4), (+)-laurotetanine (5), (+)-nornantenine (6), crychine (7), (−)-isocaryachine (8), (+)-reticuline (9), (−)-desmethylsecoantofine (10), (+)-oridine (11), dicentrinone (12) and (−)-antofine (13) were also isolated with compounds 4, 7–9 and 12–13 being characterized for the first time in this plant. Compounds 1-3 were moderate to weak AChE and BChE inhibitors while compound 10 was a DPPH free radical scavenger. Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research
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