Lupus nephritis: Role of NLRP3 inflammasomes in podocyte injury

Nature Reviews Nephrology 13, 444 (2017). doi:10.1038/nrneph.2017.91 Author: Ellen F. Carney New data implicate podocyte NLRP3 inflammasomes in the pathogenesis of lupus nephritis (LN). These inflammasomes were activated in biopsy samples from patients with LN and in lupus-prone NZM2328 mice. In the mice, NLRP3 inhibition reduced proteinuria, renal histological lesions and podocyte foot-process effacement. Sera from
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Authors: Tags: Research Highlight Source Type: research