Development: Pax2 keeps nephron progenitors on track

Nature Reviews Nephrology 13, 444 (2017). doi:10.1038/nrneph.2017.87 Author: Andrea Aguilar Low nephron numbers can increase susceptibility to chronic kidney disease. Nephrons and the surrounding interstitial tissue arise from two distinct progenitors that are separated by a lineage boundary. The molecular determinants of this fate barrier, which is largely maintained in healthy, diseased and regenerating kidneys,
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Authors: Tags: Research Highlight Source Type: research