The evolving genetic risk for sporadic ALS

Conclusions:
Previous analyses have identified SALS-predisposing variants only in terms of their rarity in normal control populations. By incorporating variant pathogenicity as well as variant frequency, we demonstrated that the genetic risk contributed by these genes for SALS is substantially lower than previous estimates.

Source: Neurology - July 17, 2017 Category: Neurology Authors: Gibson, S. B., Downie, J. M., Tsetsou, S., Feusier, J. E., Figueroa, K. P., Bromberg, M. B., Jorde, L. B., Pulst, S. M. Tags: All Neuromuscular Disease, Amyotrophic lateral sclerosis, All Genetics, Association studies in genetics ARTICLE Source Type: research