Breakthrough drug-eluting patch stops scar growth, reduces scar tissues
A new invention provides a simple, affordable and -- most importantly -- highly effective way for patients to self-treat keloid scars. It is a special patch made from polymers fabricated into microneedles, which are loaded with the US FDA-approved scar-reducing drug, 5-fluorouracil. Self-administered by patients, the microneedles attach the patch to scar tissue and allow sustained drug-release.
This study aimed to verify the suppressive effect of dipeptidyl peptidase-4 inhibitors on the formation of hypertrophic scars or keloids using real world data from the National Database of Health Insurance Claims and Specific Health Checkups of Japan. It is a retrospective cohort study, and data were extracted from the National Database between April of 2013 and March of 2015. Patients who underwent median sternotomy were included in the study based on their claimed surgical codes. Subjects who were prescribed dipeptidyl peptidase-4 inhibitors constituted the treatment group; subjects who were not prescribed or administere...
Publication date: Available online 20 June 2020Source: BurnsAuthor(s): Weiqian Jiang, Lingli Guo, Huan Wu, Jun Ying, Zheng Yang, Baohua Wei, Feng Pan, Yan Han
Authors: Zhang X, Liu W, Wei S Abstract The current experiment was performed to investigate whether luteolin affects the proliferation and apoptosis of keloid fibroblasts by regulating the expression of FRAT1 gene. Keloid fibroblasts were treated with luteolin at different concentrations. MTT method, western blot, flow cytometry, and real-time quantitative PCR (qPCR) were used to detect cell proliferation, cyclin D1 (CyclinD1), p21, B-cell lymphoma / leukemia-2 (Bcl-2), Bcl-2 related X protein (Bax), FRAT1 protein expression, apoptosis and ARHI mRNA expression. Keloid fibroblasts were transfected with si-FRAT1, or ...
Midkine (MDK) is a 15.5kDa heparin-binding growth factor induced by retinoids and inhibited by corticosteroids. It is closely related in structure to another low molecular weight protein, Pleiotrophin (PTN, 18.9kDa). Both MDK and PTN are involved in many important biological pathways including embryogenesis, tumorigenesis, and wound healing. They bind to a number of different receptors, including Protein-Tyrosine Phosphatase, Receptor-Type Zeta-1 (PTZPRZ1), which is known to play a key role in regulating cell growth, differentiation and transformation.
Fibroblasts perform a multitude of processes within skin: extracellular matrix (ECM) production, regulation of inflammation, facilitate cutaneous repair after injury, and serve as pluripotent mesenchymal cells. Recent evidence suggests that there are two main major fibroblast populations in human skin: SFRP2-expressing fibroblasts and FMO1-expressing fibroblasts, and five minor populations, each expressing discrete genes: CRABP1, COL11A1, FMO2, PRG4, or C2ORF40. Keloids are benign fibroproliferative tumors that result from an exaggerated response to cutaneous wound healing.
Keloids occur due to disturbed wound healing and abnormal collagen production, often affecting African American (AA) and Asian populations. An increased prevalence of atopic conditions, particularly asthma, has been described in keloid patients. However, its immune pathomechanism has not been studied, inhibiting therapeutic development. To evaluate the inflammatory signature of keloids in skin we obtained lesional and nonlesional biopsies from 3 AA patients with new onset keloids and 5 AA healthy controls.
Publication date: September 2020Source: Biomedicine &Pharmacotherapy, Volume 129Author(s): Tao Zhang, Xiao-Feng Wang, Zheng-Cai Wang, Dong Lou, Qing-Qing Fang, Yan-Yan Hu, Wan-Yi Zhao, Li-Yun Zhang, Li-Hong Wu, Wei-Qiang Tan
Current potential therapeutic strategies targeting the TGF-β/Smad signaling pathway to attenuate keloid and hypertrophic scar formation. Biomed Pharmacother. 2020 Jun 12;129:110287 Authors: Zhang T, Wang XF, Wang ZC, Lou D, Fang QQ, Hu YY, Zhao WY, Zhang LY, Wu LH, Tan WQ Abstract Aberrant scar formation, which includes keloid and hypertrophic scars, is associated with a pathological disorganized wound healing process with chronic inflammation. The TGF-β/Smad signaling pathway is the most canonical pathway through which the formation of collagen in the fibroblasts and myofibroblasts is regul...
• Evidence-based radiation parameters for preventing post-surgical keloid recurrence are unavailable. • Based on radiation parameters determined in vitro, a single dose of 8Gy,50kV X-rays delivered an average of 34 days after keloid excision blocked recurrence in 13 of 14 keloids, although 4 pat ients with 6 keloids were lost to follow up.
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