Stacie Pridden: My new lungs don't work any more
Stacie Pridden, 26, from Swindon, waited three years for a rare heart and double lung transplant. Here, she details her journey - and pleads for more governmental support.
Ex Vivo Lung Perfusion (EVLP) is a system that circulates normothermic perfusate into procured lungs, allowing for improved lung function and lung assessment. We investigated whether ventilation with hydrogen gas during EVLP improves the donation after cardiac death (DCD) lung function, and whether this effect persists after actual transplantation.
Limited data exists describing impact of body mass index (BMI) on post-LVAD outcomes. We sought to define the relationship between BMI and adverse events (AE) following LVAD implantation by examining the ISHLT Mechanically Assisted Circulatory Support (IMACS) registry.
Image courtesy of Paragonix Technologies Many lungs being transported for transplant arrive in such bad shape that they cannot be used. Paragonix Technologies, Inc. aims to change that with SherpaLung, a specialized cooler that keeps lungs properly inflated and at the right temperature to survive an airplane trip. Paragonix Technologies just landed support from the Lung Transplant Foundation to continue developing and commercialize SherpaLung, the latest in its series of specialized organ transport carriers. Braintree, MA-based Paragonix launched similar devices for hearts and kidneys within the past several months, a...
Abstract Exosomes are extracellular vesicles that express self-antigens (SAgs) and donor human leukocyte antigens. Tissue-specific exosomes can be detected in the circulation following lung, heart, kidney and islet cell transplantations. We collected serum samples from patients who had undergone lung (n=30), heart (n=8), or kidney (n=15) transplantations to isolate circulating exosomes. Exosome purity was analyzed by Western blot, using CD9 exosome-specific markers. Tissue-associated lung SAgs, collagen V (Col-V) and K-alpha 1 tubulin (Kα1T), heart SAgs, myosin and vimentin, and kidney SAgs, fibronectin and ...
In the current issue of the Journal of Heart and Lung Transplantation Farber and colleagues analyzed the REVEAL registry in order to investigate the impact of oxygen supplementation therapy in a large cohort of PAH patients1.
The allocation of donor hearts evolves in response to the changing landscape of advanced heart failure therapies and expanded understanding of donor/recipient matching. The novel, heart allocation algorithm is a natural response to the success of mechanical circulatory support (MCS) and further aligns severity of illness with urgency. In the novel, 6-status system, candidates supported with veno-arterial, extracorporeal membrane oxygenation devices (ECMO) and biventricular, extracorporeal ventricular assist devices (VAD) receive Status 1 urgency, while Status 2 urgency comprises candidates with univentricular extracorporea...
Internal Medicine Journal,Volume 48, Issue 6, Page 681-687, June 2018.