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Space station project seeks to crystalize the means to counteract nerve poisons

(NIH/National Institute of Neurological Disorders and Stroke) The microgravity conditions of the International Space Station (ISS) may hold the key to improving our understanding of how to combat toxic nerve agents such as sarin and VX. That is the hope of Countermeasures Against Chemical Threats (CounterACT) project that is part of an initiative at the National Institutes of Health aimed at developing improved antidotes for chemical agents.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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In conclusion, a debate exists on whether aging is a disease in itself. Some authors suggest that physiological aging (or senescence) is not really distinguishable from pathology, while others argue that aging is different from age-related diseases and other pathologies. It is interesting to stress that the answer to this question has important theoretical and practical consequences, taking into account that various strategies capable of setting back the aging clock are emerging. The most relevant consequence is that, if we agree that aging is equal to disease, all human beings have to be considered as patients to be treat...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Ergot poisoning was first described more than 2,000 years ago with the consumption of food contaminated with mycotoxins. It acquired special importance during the 20th century because of an excessive consumption of ergot pharmaceuticals as symptomatic treatment of migraine.1,2
Source: Neurology Clinical Practice - Category: Neurology Authors: Tags: Migraine, All Clinical Neurology, All Cerebrovascular disease/Stroke, Critical care Case Source Type: research
Conclusion. Modafinil is a central nervous system stimulant with well-established effectiveness in the treatment of narcolepsy and shift-work sleep disorder. There is conflicting evidence about the benefits of modafinil in the treatment of fatigue and EDS secondary to TBI. One randomized, controlled study states that modafinil does not significantly improve patient wakefulness, while another concludes that modafinil corrects EDS but not fatigue. An observational study provides evidence that modafinil increases alertness in fatigued patients with past medical history of brainstem diencephalic stroke or multiple scleros...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Current Issue Review excessive daytime sleep fatigue head injury modafinil stroke TBI traumatic brain injury Source Type: research
Abstract The measurement of cardiac troponin, released from injured cardiomyocytes, is of paramount importance in the diagnosis of acute myocardial infarction. Elevated troponin can be encountered, however, in patients with cardiomyopathy, significant cardiac arrhythmias, vasculitis, right-sided heart strain, critical systemic illnesses, stroke, drug toxicity (such as Adriamycin), poisons (such as snake venoms), renal failure, seizure, and rhabdomyolysis. If the clinical picture is not consistent with any of these causes, a false-positive result should be considered. We herein describe a 94-year-old man with a pri...
Source: Baylor University Medical Center Proceedings - Category: Universities & Medical Training Authors: Tags: Proc (Bayl Univ Med Cent) Source Type: research
ConclusionNine out of ten chronic neurological diseases were associated with an increased risk of suicide attempt. These data must be considered for clinicians treating this vulnerable group of patients.
Source: Journal of Neurology - Category: Neurology Source Type: research
It’s no secret that binge drinking is common in the U.S., as a visit to most college campuses will demonstrate. But a new report from the Centers for Disease Control and Prevention (CDC) finds that the practice is widespread beyond the college years, well into adulthood. More than 37 million Americans, or 17% of the adult population, reported binge drinking — defined as consuming four or more drinks in one sitting for women, or five or more for men — at least once in 2015, according to the report. Many people binge drank far more frequently than that: The average number of episodes per binge drinker was 5...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime onetime public health Source Type: news
This study identifies the missing link between Lewy bodies and the type of damage that's been observed in neurons affected by Parkinson's. Parkinson's is a disorder of the mitochondria, and we discovered how Lewy bodies are releasing a partial break-down product that has a high tropism for the mitochondria and destroys their ability to produce energy." Lewy bodies were described a century ago, but it was not until 1997 that scientists discovered they were made of clumps of a misfolded protein called α-synuclein. When it's not misfolded, α-synuclein is believed to carry out functions related to the ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Discussion With new developments in computational power and data availability, a growing amount of research is using a systems biology approach to understand pathogenesis and progression of disease. Effective and integrated in vitro and in silico models could inform biological phenomena, even without the need of a living subject. For instance, over the last few decades, collagen hydrogel with muscle derived cells (CHMDCs) have promised to revolutionize in vitro experiments and tissue engineering. For CHMDCs to reach the envisioned use, verification by use of mathematical simulations are needed. Recently while examining sha...
Source: PLOS Currents Muscular Dystrophy - Category: Neurology Authors: Source Type: research
INTRODUCTION: Takayasu arteritis (TA) is a rare large vessel arteritis, affecting primarily aorta and its major branches. Its clinical manifestations can vary significantly - from asymptomatic to serious vascular events. Acute neurological complications ar...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Poisoning Source Type: news
Acute global amnesia can occur, due to bilateral hippocampus dysfunction. Causes include the idiopathic syndrome of transient global amnesia, bilateral posterior circulation stroke,. toxic anoxia due to carbon monoxyde poisoning and substance abuse probably combining hypoxia and direct hippocampal neurotoxicity.
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Tags: Letter to the Editor Source Type: research
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