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Adrenaline Overdose in Pediatric Anaphylaxis: A Case Report Adrenaline Overdose in Pediatric Anaphylaxis: A Case Report

Appropriate administration of adrenaline in pediatric anaphylaxis remains challenging. How does blood pressure help differentiate progression of anaphylaxis symptoms from adrenaline toxicity?Journal of Medical Case Reports
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Pediatrics Journal Article Source Type: news

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This study aimed to determine the clinical value, and potential cardiovascular harm, on elderly patients with anaphylaxis who received intramuscular (IM) and IV epinephrine. Over a five-year period, the researchers examined the ED record of anaphylactic patients over the age of 50 who were transported to two urban EDs. They compared the clinical outcome and cardiovascular complications between younger and older adults who received epinephrine for anaphylaxis. Of the 2,995 patients with allergy-related complaints, 492 were treated for anaphylaxis. Of them, 122 (24.8%) were older adults. Only 36.1% of the older patients rece...
Source: JEMS Patient Care - Category: Emergency Medicine Authors: Tags: Patient Care Columns Source Type: news
ConclusionsThe consequences of under-dosing adrenaline in anaphylaxis are well-recognized, but the converse is less so. Blood pressure measurement should be a routine part of pediatric assessment as it is key to differentiating adrenaline overdose from anaphylactic shock.
Source: Journal of Medical Case Reports - Category: Journals (General) Source Type: research
ConclusionsThis study confirms that early ECG evaluation is essential to assess the cardiovascular prognosis and medical clearance of emergency department patients with acute drug overdose. Furthermore, this study validates previously derived high‐risk features of the admission ECG to risk stratify for ACVE in this patient population.
Source: JAHA:Journal of the American Heart Association - Category: Cardiology Authors: Tags: Clinical Studies, Cardiopulmonary Resuscitation and Emergency Cardiac Care, Electrocardiology (ECG), Prognosis Original Research Source Type: research
Abstract Pharmacists are in demand not only because of their knowledge of medical therapy but also due to their skills in basic physical assessment and emergency care as medical personnel. Pharmaceutical education has developed using patient simulators in bedside training, seminars in hospital pharmacies, and physical assessment practice at the Kyushu University of Health and Welfare School of Pharmaceutical Sciences. We first explain the outline of the method to confirm basic vital signs with simulators and then demonstrate some simulations to enable the reproduction of drug misadministration/changes in condition...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - Category: Drugs & Pharmacology Authors: Tags: Yakugaku Zasshi Source Type: research
Community distribution, use by first responders and co-prescribing of the opioid antagonist naloxone has been shown to reverse prescription opioid and heroin overdose and save lives across the country. But how do you explain the safety benefits of a naloxone prescription to your patients without the stigma that overdose carries? Learn how one physician approaches this issue in a way that helps patients understand that co-prescribing naloxone is for their own safety and well-being. Naloxone has saved tens of thousands of lives and will save many more as its availability continues to increase throughout the country. Some p...
Source: AMA Wire - Category: Journals (General) Authors: Source Type: news
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Source: Basic and Clinical Pharmacology and Toxicology - Category: Drugs & Pharmacology Authors: Tags: Annotations & Reflections Source Type: research
  EMS was called for middle-aged man, found slumped over a table at restaurant. He had quite a poor mental status and could not offer any medical history. Per the staff he had just arrived, and not eaten or drank anything. Although he is carrying a home glucometer, his blood sugar is 160. He has a new-ish looking hospital wrist band on, but no shoes. Systolic BP in the 80s, and HR around 160.  Dry, hot skin, and the rest of the exam isn’t revealing. IVs are started, and a rhythm strip obtained: And a 12-lead:So, what do we have so far? And what do we do with the ECG findings?   What does the ECG show? ...
Source: EMS 12-Lead - Category: Cardiology Authors: Tags: Uncategorized Source Type: research
Conclusion Opioid reversal protocols should be developed by a multi-disciplinary team. Each protocol should differentiate those toxicities which are life-threatening and require complete opioid reversal with toxicities that require small aliquots of naloxone to mitigate the presenting symptoms.
Source: Journal of Oncology Pharmacy Practice - Category: Cancer & Oncology Authors: Tags: Review Articles Source Type: research
Abstract Adrenaline (epinephrine) auto-injectors provide life-saving pre-hospital treatment for individuals experiencing anaphylaxis in a community setting. Errors in handling adrenaline auto-injectors, particularly by children and healthcare professionals, have been reported. Reports of adrenaline overdoses are limited in the medical literature. In most of these cases, accidental adrenaline administration results from medical error. Exogenous administration of catecholamine is responsible for cardiovascular and metabolic responses, which may cause supraventricular tachycardia, ventricular dysrhythmias and myocard...
Source: Forensic Science, Medicine, and Pathology - Category: Forensic Medicine Source Type: research
Publication date: June 2015 Source:Journal of Acute Disease, Volume 4, Issue 2 Author(s): Yu-Jang Su Urticaria is a systemic allergic reaction leading to wheal formation with skin itching. Occasionally we come across some intractable cases, in which we may administrate epinephrine infusion besides steroid and anti-histamine. A 19 year-old man suffered from intractable urticaria for 2 days, although anti-histamine and steroids were used. Titration of adrenaline was considered in the treatment of intractable urticaria. He was administrated 1 mg epinephrine intravenous bolus due to mis-dilution by the nurse. Transient atria...
Source: Journal of Acute Disease - Category: Emergency Medicine Source Type: research
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