Med15B regulates acid stress response and tolerance in Candida glabrata.

This study explored the role of the Mediator tail subunit Med15B in the metabolism of Candida glabrata under acidic conditions. Overexpression of MED15B enhanced yeast tolerance to low pH and improved biomass production, cell viability, and pyruvate yield. Membrane lipid composition data indicated that Med15B might play a critical role in membrane integrity, fluidity, and H(+)-ATPase activity homeostasis at low pH. Thus, controlling membrane composition may serve to increase C. glabrata productivity at low pH. PMID: 28710262 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/28710262?dopt=Abstract

Source: Applied and Environmental Microbiology - July 14, 2017 Category: Microbiology Authors: Qi Y, Liu H, Yu J, Chen X, Liu L Tags: Appl Environ Microbiol Source Type: research