One and two-year persistence with different anti-osteoporosis medications: a retrospective cohort study

AbstractSummaryAdherence to anti-osteoporosis medications is poor. We carried out a cohort study using a real-world population database to estimate the persistence of anti-osteoporosis drugs. Unadjusted 2-year persistence ranged from 10.3 to 45.4%. Denosumab users had a 40% lower risk of discontinuation at 2  years compared to alendronate users.PurposeThe purpose of this study was to estimate real-world persistence amongst incident users of anti-osteoporosis medications.MethodsThis is a retrospective cohort using data from anonymised records and dispensation data ( Eligibility comprised the following: women aged ≥50, incident users of anti-osteoporosis medication (2012), with data available for at least 12 months prior to therapy initiation. Exclusions are other bone diseases/treatments and uncommon anti-osteoporosis drugs (N 
Source: Osteoporosis International - Category: Orthopaedics Source Type: research

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ConclusionsSignificant associations between infant milk feeding and lumbar spine BMD in males indicate that breastmilk may be protective for the bone health of male babies. The evidence presented here underscores the potential lifelong benefits of breastfeeding and may highlight the differences between osteoporotic risk factors for males and females.
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
(Mary Ann Liebert, Inc./Genetic Engineering News) A new study has shown that gene therapy to treat one of the most common hereditary disorders, aldehyde dehydrogenase type 2 (ALDH2) deficiency, may prevent increased risk for esophageal cancer and osteoporosis associated with chronic alcohol exposure.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news
-Arendarczyk The aim of this study was to determine the concentrations of iron, nickel, molybdenum, and vanadium in the knee joint. We also examined the relationships between the concentrations of these metals in the knee joint and the influence of varied factors on the concentration of Fe, Ni, Mo, and V. The study of these trace elements is important, because these elements are used alone and in combination in diet supplements, and they are components of biomaterials implanted in medicine. The study materials, consisting of the spongy bone, cartilage, meniscus, anterior cruciate ligament (ACL), and infrapatellar fat p...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Comorbidity is the presence of one or more additional conditions co-occurring with a primary condition. In this episode, host schizophrenic Rachel Star Withers with her cohost Gabe Howard will be discussing comorbidity with schizophrenia. Comorbidity is associated with worse health outcomes, more complex clinical management and increased health care costs. Occupational therapist and host of the podcast Occupied, Brock Cook, will be joining us to discuss ways that he works with people with schizophrenia to manage multiple health issues.  Highlights from “Comorbidity with Schizophrenia” Episode [01:28] What ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Antipsychotic Inside Schizophrenia Mental Health and Wellness Psychiatry Psychology Psychotherapy Bipolar disorder and schizophrenia comorbid comorbid psychiatric conditions Comorbidities Comorbidity Diagnosis Of Schizophrenia Livi Source Type: blogs
Conclusions: This study calls for immediate and effective interventions for middle-aged and elderly populations with risk factors to halt the progression of bone loss.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
ConclusionsThe risk of non-vertebral osteoporotic fracture increased with declining grip-strength in both genders, particularly in men aged 50 –64 years.
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
AbstractOsteoporosis (OP) is a multi-factorial bone disease influenced by genetic factors, age, and lifestyles. The aim of this study is to evaluate the genetic correlations between OP and multiple lifestyle-related factors, and explore the genes underlying the detected genetic correlations. Linkage disequilibrium score regression (LDSC) analysis was applied to evaluate the genetic correlations of total body bone mineral density (TB-BMD) of different ages (including 15 –30 years, 30–45 years, 45–60 years, and over 60 years) with four common lifestyle/environment-related factors (includ...
Source: Calcified Tissue International - Category: Orthopaedics Source Type: research
Background: To date, limited data exist on airflow limitation (COPD) and bone mineral density in Japan.Aims and Objectives: To assess the association between airflow limitation (AL) severity and reduced bone density in Japanese males.Methods: This cross-sectional study included 296 subjects (mean age 71.2, SD 12.7), who underwent a comprehensive health examination that included spirometry and measurement of bone mineral density (BMD) at the left femoral neck on DXA in 2016-2017 at Japanese Red Cross Kumamoto Health Care Center. AL was defined as FEV1 / FVC of
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Epidemiology Source Type: research
ConclusionSince TBS and SQ1 –SQ3 fractures were not associated, they may act as independent risk factors, justifying the use of both in post-fracture risk assessment.
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
ABSTRACTShort sleep duration, recognized as a public health epidemic, is associated with adverse health conditions, yet little is known about the association between sleep and bone health. We tested the associations of usual sleep behavior and bone mineral density (BMD) and osteoporosis. In a sample of 11,084 postmenopausal women from the Women's Health Initiative (WHI; mean age 63.3  years, SD = 7.4), we performed a cross‐sectional study of the association of self‐reported usual hours of sleep and sleep quality (WHI Insomnia Rating Score) with whole body, total hip, femoral neck, and spine BMD using linear regr...
Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Original Article Source Type: research
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