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The Role of Genomic Techniques in Predicting Response to Radiation Therapy

The understanding of the relationship between genetic variation and an individual patient ’s response to radiation therapy has gained significant ground over the past several years. Genetic markers have been identified that could ultimately serve as the foundation for predictive models in clinical practice, and that hold the potential to revolutionize the delivery of precision medicine in oncology.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Tags: Oncology Journal Radiation Oncology Review Article Source Type: news

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AbstractThe novel anti-mitotic based tumor treating fields (TTFields) is FDA approved for recurrent glioblastoma. Recently the phase III upfront trial combining the Novo TTF-100A device, called Optune, with temozolomide following concurrent radiation therapy and chemotherapy, demonstrated improvement in survival. Wider use of this novel therapy is expected. The most common adverse event is dermatologic, which dominates compared to the next most frequently observed adverse event of headaches, the incidence of which was even in both arms in the phase III registration trial for recurrent glioblastoma. Our case review outlines...
Source: Journal of Neuro-Oncology - Category: Cancer & Oncology Source Type: research
Abstract Osteonecrosis is the devitalization of bone and consequent lytic changes. In the jaws, osteonecrosis is a pathologic consequence of prior radiation therapy (osteoradionecrosis) or certain antiresorptive medications. Herein, we review the pathogenesis and clinical manifestations of these lesions, and describe the spectrum of radiologic findings in these conditions, and highlight the similarities and differences between the imaging appearances of these 2 entities. PMID: 29157550 [PubMed - in process]
Source: Radiologic Clinics of North America - Category: Radiology Authors: Tags: Radiol Clin North Am Source Type: research
We report the case of a 51-year-old female, in whom coronary artery disease such as occlusion of septal perforators was manifested, on the occasion of hospitalization with congestive heart failure. The patient had a history of radiation therapy for a mediastinal tumor 19 years previously. As she had no conventional coronary risk factors, the cause of the coronary artery disease is thought to have been related to the radiation therapy. As survival rates of cancer patients improve as a consequence of therapeutic advances, we should be aware of the possibility of coronary artery disease as a very late complication of radiatio...
Source: International Heart Journal - Category: Cardiology Tags: Int Heart J Source Type: research
Authors: Li Y, Tao S, Li M, Li D Abstract Multimodal treatment approaches are indispensable for patients with advanced-stage cancer, while radiation therapy has been established as essential part of therapeutic approaches and has been introduced as a better option to face challenges, such as, local relapse or oligometastatic disease. The mere insight of the concept of oligometastases, proposed for the first time in the middle 1990s, led to the hypothesis that this condition may be cured using local ablative weapons. This hypothesis has already been demonstrated by surgical ablative techniques. Even though been cons...
Source: Journal of B.U.ON. - Category: Cancer & Oncology Tags: J BUON Source Type: research
AbstractPurposeThe purpose of our study was to assess18F –DCFBC PET/CT, a PSMA targeted PET agent, for lesion detection and clinical management of biochemical relapse in prostate cancer patients after primary treatment.MethodsThis is a prospective IRB-approved study of 68 patients with documented biochemical recurrence after primary local therapy consisting of radical prostatectomy (n = 50), post radiation therapy (n = 9) or both (n = 9), with negative conventional imaging. All 68 patients underwent whole-body18F –DCFBC PET/CT, and 62 also underwent mpMRI within one month. Lesion d...
Source: European Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
Whole pelvic radiation therapy (WPRT) and androgen deprivation therapy (ADT) reduce the risk of biochemical failure in men who receive post-prostatectomy salvage radiotherapy for prostate cancer, according to a database study.Reuters Health Information
Source: Medscape Radiology Headlines - Category: Radiology Tags: Hematology-Oncology News Source Type: news
Conclusion: IORT could have a negative effect on seroma formation, SSI, and delayed healing. It should be kept in mind, however, that in centers with IORT implementation, the complication rate could also increase. Necessary measures for better sterilization in the operating room should be taken, while patient wound healing should be monitored closely. PMID: 29156861 [PubMed]
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
Surgery is potentially curative for primary non‐metastatic retroperitoneal soft tissue sarcomas (RPS), although patients remain at risk for local recurrence. To reduce this risk, the addition of radiotherapy to radical surgery may be considered. Nevertheless, level I evidence to support radiotherapy is currently lacking. The results from the EORTC‐STBSG 62092‐22092 studying this question are awaited. This manuscript addresses issues to consider when radiation‐oncologists engage in a multidisciplinary treatment approach for RPS patients, including radiotherapy.
Source: Journal of Surgical Oncology - Category: Cancer & Oncology Authors: Tags: REVIEW ARTICLE Source Type: research
Commissioning a new treatment planning system (TPS) involves many time-consuming tasks. We investigated the role that knowledge-based planning (KBP) can play in aiding a clinic's transition to a new TPS. Sixty clinically treated prostate/prostate bed intensity-modulated radiation therapy (IMRT) plans were exported from an in-house TPS and were used to create a KBP model in a newly implemented commercial application. To determine the benefit that KBP may have in a TPS transition, the model was tested on 2 groups of patients.
Source: Medical Dosimetry - Category: Radiology Authors: Tags: Medical Physics Contribution: Source Type: research
This prospective, longitudinal study assesses objective neurocognitive function before and after definitive radiation therapy for patients with head and neck cancer.
Source: JAMA Otolaryngology - Head and Neck Surgery - Category: ENT & OMF Source Type: research
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