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Forensic aspects of homicides by insulin overdose - Tong F, Wu R, Huang W, Yang Y, Zhang L, Zhang B, Chen X, Tang X, Zhou Y.

Analysis of homicidal insulin overdose is a challenging task in forensic practice because of the difficulties in toxicological analysis as well as the elusive pathologic changes. We performed a detailed histopathologic examination on four autopsy cases inv...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

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Source: Drug and Alcohol Dependence - Category: Addiction Authors: Tags: Full length article Source Type: research
BACKGROUND: Opioid overdose is a major and increasing cause of injury and death. There is an urgent need for interventions to reduce overdose events among high-risk persons. METHODS: Adults at elevated risk for opioid overdose involving heroin or p...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
This report describes 4 cases of deaths associated with brotizolam poisoning from a single drug overdose. The ages ranged from 51 to 90 years, and the postmortem interval between death and tissue sampling was 1.5 to 2.5 days. These deaths were classified as 1 homicide and 3 suicides. The concentration of the brotizolam ranged from 0.05 to 0.21 mg/L in the blood samples. Ethanol, which could cause mild alcohol intoxication, was detected in the blood samples from 2 cases. Postmortem examinations did not find any significant pathologic conditions, except for a case of death by drowning in a bathtub due to brotizolam poisoning...
Source: The American Journal of Forensic Medicine and Pathology - Category: Forensic Medicine Tags: Case Reports Source Type: research
Acetaminophen (APAP) is the leading cause of acute liver failure (ALF), although the worldwide frequency is variable. APAP hepatotoxicity develops either following intentional overdose or unintentional ingestion (therapeutic misadventure) in the background of several factors, such as concomitant use of alcohol and certain medications that facilitate the formation of reactive and toxic metabolites. Spontaneous survival is more common in APAP-induced ALF compared with non-APAP etiologies. N-acetylcysteine is recommended for all patients with APAP-induced ALF and it reduces mortality. Liver transplantation should be offered e...
Source: Clinics in Liver Disease - Category: Gastroenterology Authors: Source Type: research
Source: Drug and Alcohol Dependence - Category: Addiction Authors: Tags: Short communication Source Type: research
U.S. life expectancy has decreased for the second year in a row, and an editorial in the BMJ points to three contributing factors: drugs, alcohol and suicides, particularly among middle-age white Americans and those living in rural communities. The authors of the paper paint a bleak picture of the problems facing much of the United States today, but the authors say that policies that bolster the middle-class can help reverse the trend. The recent drop in life expectancy is alarming, the editorial states, “because life expectancy has risen for much of the past century in developed countries, including in the U.S.&rdqu...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime onetime public health Source Type: news
Okay, everyone knows smoking is bad for you, the number one cause of preventable death in the US and the world, a direct cause of lung and heart disease and cancer… et cetera. So let’s get right down to the nitty-gritty: quitting smoking is tough. What can people do to quit? To answer this question, I spoke with my colleague Nancy Rigotti, MD. Dr. Rigotti is director of the Massachusetts General Hospital Tobacco Research and Treatment Center. She has extensively researched nicotine and tobacco, evaluated public policies on tobacco, contributed to US Surgeon General’s Reports, and authored clinical guidel...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Heart Health Lung disease Prevention Smoking cessation Source Type: blogs
Last month, supervised injection facilities, also known as safe injection facilities (SIFs), were thrust back into the news when Philadelphia officials announced the city would likely become the first in the U.S. to adopt the controversial tactic for fighting opioid abuse. SIFs, which currently operate in Canada, Europe and Australia, offer drug users a place to use heroin and other narcotics under the supervision of medical professionals. (SIFs do not provide drugs, nor do their employees inject users directly.) Proponents say they can help curb overdose deaths, improve injection hygiene and expand access to addiction tre...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Drugs healthytime onetime Philadelphia Source Type: news
Abstract Introduction and AimsThere is a current epidemic of pharmaceutical opioid (PO) misuse, particularly fentanyl and fentanyl analogues, globally. Fentanyl is a highly potent synthetic opioid with rapid onset and significantly higher risk of overdose compared with other opioids. Contexts and correlates of fentanyl use among people who inject drugs (PWID) in Australia are under‐researched. Design and MethodsThe Australian Needle Syringe Program Survey is conducted annually. Consenting PWID complete a self‐administered questionnaire and provide a capillary dried blood spot for human immunodeficiency virus and hepati...
Source: Drug and Alcohol Review - Category: Addiction Authors: Tags: Original Paper Source Type: research
Psychosocial stress, defined here as socioenvironmental demands that tax the adaptive capacity of the individual (e.g., low socioeconomic status, childhood adversity, bullying), has repeatedly been linked to substance use disorders (SUDs). Neighborhood poverty and social support are shown to influence substance use patterns. Among smokers, multiple psychosocial stressors are associated with relapse, and acute psychosocial stress has been demonstrated to enhance cigarette craving and smoking behavior. Similarly, psychosocial stress has been associated with greater risk of relapse in individuals with alcohol and cocaine use ...
Source: Psychology of Pain - Category: Anesthesiology Source Type: blogs
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