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Fighting TB with Open-Source Tech

VideoFighting TB with Open-Source TechJuly 14, 2017EndTB (Expand New Drug markets for Tuberculosis) is a comprehensive international project that aims to find shorter, less toxic, oral-only, and more effective treatments for TB.Read more about how MSF is helping patients get access to new TB drugs.  
Source: MSF News - Category: International Medicine & Public Health Authors: Source Type: news

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CONCLUSIONS: The exceptional accuracy demonstrated by Kit SIRE Nitratase for isoniazid and rifampicin makes the kit an attractive option for screening M. tuberculosis strain resistance.
Source: Revista da Sociedade Brasileira de Medicina Tropical - Category: Tropical Medicine Source Type: research
Abstract Seven months after undergoing kidney transplantation, a 56-year-old woman presented with papules and ulcers in her right forearm. The patient received antibiotics for 8 months with limited improvement. Eleven months after symptom onset, she presented with acute arthritis in her left knee. Asynovial fluid culture yielded Mycobacterium tuberculosis, and a forearm ulcer biopsy showed granulomatous inflammation. After surgical fistulectomy and 12 months of tuberculosis treatment, she was cured. Chronic cutaneous ulcers and articular manifestations in TB are rare, but they should always be considered in the differentia...
Source: Revista da Sociedade Brasileira de Medicina Tropical - Category: Tropical Medicine Source Type: research
We present a patient who had MOP deficiency, who presented with a subacute form of paracoccidioidomycosis and later with peritoneal tuberculosis. MOP deficiency leads to the diminished destruction of phagocytized pathogens. This case gives important evidence of an association between MOP deficiency and increased susceptibility to infection by Paracoccidioides brasiliensis and Mycobacterium tuberculosis.
Source: Revista da Sociedade Brasileira de Medicina Tropical - Category: Tropical Medicine Source Type: research
Conclusions: The predominant HRCT pattern was ground-glass attenuation with consolidation, followed by cavitation and centrilobular nodules with a tree-in-bud pattern. These findings are similar to those reported for immunocompetent patients with pulmonary tuberculosis and considerably different from those reported for AIDS patients with the same disease.RESUMO Objetivo: As infec ções respiratórias constituem a principal causa de morbidade e mortalidade em transplantados de órgãos sólidos. A incidência de tuberculose pulmonar é alta entre esses pacientes. Em exames de ...
Source: Jornal Brasileiro de Pneumologia - Category: Respiratory Medicine Source Type: research
This report underscores the fact that pulmonary foreign body granulomatosis should be included in the differential diagnosis of clinical profiles resembling tuberculosis.RESUMO Descrevemos o caso de um homem de 33 anos de idade, usu ário crônico de cocaína em pó, que apresentava dispneia, febre, sudorese noturna e perda de peso significativa. A TCAR de tórax revelou nódulos centrolobulares, dando uma impressão inicial de tuberculose miliar. Por isso, o paciente passou a receber tratamento empírico com quatro tuberculost áticos. Quatro semanas depois, apesar do t...
Source: Jornal Brasileiro de Pneumologia - Category: Respiratory Medicine Source Type: research
This report underscores the fact that pulmonary foreign body granulomatosis should be included in the differential diagnosis of clinical profiles resembling tuberculosis.RESUMO Descrevemos o caso de um homem de 33 anos de idade, usu ário crônico de cocaína em pó, que apresentava dispneia, febre, sudorese noturna e perda de peso significativa. A TCAR de tórax revelou nódulos centrolobulares, dando uma impressão inicial de tuberculose miliar. Por isso, o paciente passou a receber tratamento empírico com quatro tuberculost áticos. Quatro semanas depois, apesar do t...
Source: Jornal Brasileiro de Pneumologia - Category: Respiratory Medicine Source Type: research
This report underscores the fact that pulmonary foreign body granulomatosis should be included in the differential diagnosis of clinical profiles resembling tuberculosis.RESUMO Descrevemos o caso de um homem de 33 anos de idade, usu ário crônico de cocaína em pó, que apresentava dispneia, febre, sudorese noturna e perda de peso significativa. A TCAR de tórax revelou nódulos centrolobulares, dando uma impressão inicial de tuberculose miliar. Por isso, o paciente passou a receber tratamento empírico com quatro tuberculost áticos. Quatro semanas depois, apesar do t...
Source: Jornal Brasileiro de Pneumologia - Category: Respiratory Medicine Source Type: research
This report underscores the fact that pulmonary foreign body granulomatosis should be included in the differential diagnosis of clinical profiles resembling tuberculosis.RESUMO Descrevemos o caso de um homem de 33 anos de idade, usu ário crônico de cocaína em pó, que apresentava dispneia, febre, sudorese noturna e perda de peso significativa. A TCAR de tórax revelou nódulos centrolobulares, dando uma impressão inicial de tuberculose miliar. Por isso, o paciente passou a receber tratamento empírico com quatro tuberculost áticos. Quatro semanas depois, apesar do t...
Source: Jornal Brasileiro de Pneumologia - Category: Respiratory Medicine Source Type: research
This report focuses on the lack of new antibiotics under development to combat the growing threat of antimicrobial resistance. The report found very few potential treatment options for those antibiotic-resistant infections identified by WHO as posing the greatest threat to health.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
Authors: Lall N, Meyer JJM, Wang Y, Bapela NB, van Rensburg CEJ, Fourie B, Franzblau SG Abstract Naphthoquinones and triterpenes isolated from the roots of Euclea natalensis. A.DC (Ebenaceae) were evaluated for their inhibitory activity against Mycobacterium tuberculosis.. Crude extract, diospyrin and 7-methyljuglone isolated from the plant, exhibited minimum inhibitory concentrations of 8.0, 8.0, and 0.5 µg ml(-1), respectively, against M. tuberculosis. H37 Rv (ATCC 27294), a drug-sensitive strain. Minimum inhibitory concentrations (MICs) of 7- methyljuglone against a panel of clinical pan-sensitive and drug...
Source: Pharmaceutical Biology - Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research
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