Delivery of brief interventions for heavy drinking in primary care: outcomes of the ODHIN 5-Country Cluster Randomized Trial - Anderson P, Coulton S, Kaner E, Bendtsen P, K łoda K, Reynolds J, Segura L, Wojnar M, Mierzecki A, Deluca P, Newbury-Birch D, Parkinson K, Okulicz-Kozaryn K, Drummond C, Gual A.

PURPOSE: We aimed to test whether 3 strategies-training and support, financial reimbursement, and an option to direct screen-positive patients to an Internet-based method of giving brief advice-have a longer-term effect on primary care clinicians' delivery...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

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This study investigated the risk of dementia by type in patients with schizophrenia. METHODS: Data were collected from the Taiwanese National Health Insurance Database 2005 and analyzed using multivariate Cox proportional hazard regression models to determine the effect of schizophrenia on the dementia risk after adjusting for demographic characteristics, comorbidities, and medications. Fine and Gray's competing risk analysis was used to determine the risk of dementia, as death can act as a competing risk factor for dementia. RESULTS: We assessed 6040 schizophrenia patients and 24,160 propensity scale-matched contr...
Source: Journal of the Association of European Psychiatrists - Category: Psychiatry Tags: Eur Psychiatry Source Type: research
ki Nakamura Tea is one of the most consumed beverages in the world. Green tea, black tea, and oolong tea are made from the same plant Camellia sinensis (L.) O. Kuntze. Among them, green tea has been the most extensively studied for beneficial effects on diseases including cancer, obesity, diabetes, and inflammatory and neurodegenerative diseases. Several human observational and intervention studies have found beneficial effects of tea consumption on neurodegenerative impairment, such as cognitive dysfunction and memory loss. These studies supported the basis of tea’s preventive effects of Parkinson’...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Publication date: Available online 7 May 2018 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Author(s): Sandip Patel, Bethan S. Kilpatrick Two-pore channels (TPCs) are Ca2+-permeable endo-lysosomal ion channels subject to multi-modal regulation. They mediate their physiological effects through releasing Ca2+ from acidic organelles in response to cues such as the second messenger, NAADP. Here, we review emerging evidence linking TPCs to disease. We discuss how perturbing both local and global Ca2+ changes mediated by TPCs through chemical and/or molecular manipulations can induce or reverse disease ph...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - Category: Molecular Biology Source Type: research
Abstract Two-pore channels (TPCs) are Ca2+-permeable endo-lysosomal ion channels subject to multi-modal regulation. They mediate their physiological effects through releasing Ca2+ from acidic organelles in response to cues such as the second messenger, NAADP. Here, we review emerging evidence linking TPCs to disease. We discuss how perturbing both local and global Ca2+ changes mediated by TPCs through chemical and/or molecular manipulations can induce or reverse disease phenotypes. We cover evidence from models of Parkinson's disease, non-alcoholic fatty liver disease, Ebola infection, cancer, cardiac dysfunction ...
Source: Biochimica et Biophysica Acta - Category: Biochemistry Authors: Tags: Biochim Biophys Acta Source Type: research
Dementia presents as a group of symptoms, and Alzheimer's disease is the most common cause of dementia.By Bob DeMarcoAlzheimer's Reading RoomWhen someone is told they have Alzheimer's or dementia,it means they have significant memory problems as well as other cognitive and behavioral issues.Most of the time dementia is caused by Alzheimer's disease.There is great confusion about the difference betweenAlzheimer's anddementia.In a nutshell, dementia isn't a specific disease. Instead, dementia describes a group of symptoms affecting memory, thinking and social abilities severely enough to interfere with daily functioning. Alz...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: alzheimer's Alzheimer's Dementia Alzheimer's disease alzheimer's symptoms alzheimer's vs dementia the difference between alzheimer's and dementia Source Type: blogs
BACKGROUND: Methamphetamine use has been posited to be a risk factor for the development of Parkinson's disease (PD) and parkinsonism. The clinical implications of a potential association between methamphetamine use and PD are considered. METHODS: ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
Source: Drug and Alcohol Dependence - Category: Addiction Authors: Tags: Review Source Type: research
Methamphetamine use is a significant public health problem, with an estimated 35 million stimulant users worldwide, predominantly of methamphetamine (Degenhardt and Hall, 2012; Degenhardt et al., 2013; UNODC, 2016). Harmful physical and mental health consequences are common, including cardiovascular and cerebrovascular pathology, psychosis, suicide and premature mortality (Callaghan et al., 2012a; Darke et al., 2008, 2011; Karch, 2015). The stimulants methamphetamine and its active metabolite amphetamine are highly related and are hereafter referred to as methamphetamine (McKetin et al., 2016)
Source: Drug and Alcohol Dependence - Category: Addiction Authors: Tags: Review Source Type: research
According to the Alzheimer’s Association, “Today, someone in the United States develops Alzheimer’s every 65 seconds. By mid-century, someone in the United States will develop the disease every 33 seconds.” To date, there is no cure regarding this most common form of dementia, which affects nearly all individuals worldwide regardless of race, or socioeconomic status, a trend that continues to grow at a disturbingly alarming rate. Scientists however are close to identifying contributing factors that may hinder or help the progression of this illness in the long run. Listed below are the top 5 f...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Aging Alzheimer's Health-related Memory and Perception Stress Alzheimer's disease Memory Loss Source Type: blogs
BACKGROUND: Even after accounting for deprivation, mortality rates are higher in Scotland relative to the rest of Western Europe. Higher mortality from alcohol- and drug-related deaths (DRDs), violence and suicide (particularly in young adults) contribute ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
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