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Delivery of brief interventions for heavy drinking in primary care: outcomes of the ODHIN 5-Country Cluster Randomized Trial - Anderson P, Coulton S, Kaner E, Bendtsen P, K łoda K, Reynolds J, Segura L, Wojnar M, Mierzecki A, Deluca P, Newbury-Birch D, Parkinson K, Okulicz-Kozaryn K, Drummond C, Gual A.

PURPOSE: We aimed to test whether 3 strategies-training and support, financial reimbursement, and an option to direct screen-positive patients to an Internet-based method of giving brief advice-have a longer-term effect on primary care clinicians' delivery...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

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Authors: Danek M, Danek J, Araszkiewicz A Abstract Many animal models in different species have been developed for mental and behavioral disorders. This review presents large animals (dog, ovine, swine, horse) as potential models of this disorders. The article was based on the researches that were published in the peer-reviewed journals. Aliterature research was carried out using the PubMed database. The above issues were discussed in the several problem groups in accordance with the WHO International Statistical Classification of Diseases and Related Health Problems 10thRevision (ICD-10), in particular regarding: ...
Source: Psychiatria Polska - Category: Psychiatry Tags: Psychiatr Pol Source Type: research
Publication date: Available online 12 February 2018 Source:Journal of Psychiatric Research Author(s): Hyewon Lee, Woojae Myung, Chunsoo Lee, Junbae Choi, Ho Kim, Bernard J. Carroll, Doh Kwan Kim We investigated the effects of a large range of clinical factors on the long-term risk of suicide in the general population of South Korea. We analyzed the National Health Insurance Service-National Sample Cohort (NHIS-NSC) database in South Korea. A total of 300,232 individuals were followed for up to 12 years. We obtained information on demographic variables (age and sex), lifestyle variables (cigarette smoking, alcohol drinking...
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
Aldehyde dehydrogenase enzymes (ALDHs) have a broad spectrum of biological activities through the oxidation of both endogenous and exogenous aldehydes. Unbalanced biological activity of ALDHs has been associated with a variety of disease states such as alcoholic liver disease, Parkinson ’s disease, obesity, and Cancer. Increased expression of ALDH1A1 has been identified in a wide-range of human cancer stem cells and is associated with cancer relapse and poor prognosis, raising the potential of ALDH1A1 as a therapeutic target.We performed a systematic medicinal chemistry optimization and biological characterization of...
Source: NIH OTT Licensing Opportunities - Category: Research Authors: Source Type: research
How common are dye eyes?The prevalence of dry eyes has been estimated to be 5-30% percent in persons aged 50 years and older, 7% of US adult population has been diagnosed with dry eye disease. The prevalence increases with age (2.7% in those 18 to 34 years old vs. 19% in those aged 75 years and older). Prevalence is higher in women than men (9% versus 4%).What are the risk factors for dry eye disease?- Advanced age- Female gender- Hormonal changes (primarily due to decreased androgens)- Systemic diseases (eg, diabetes mellitus, Parkinson disease)- Contact lens wear- Systemic medications (antihistamines, anticholinergi...
Source: Clinical Cases and Images - Blog - Category: Universities & Medical Training Authors: Tags: Ophthalmology Source Type: blogs
Several studies reported that cancer is less frequent in persons with Alzheimer's and Parkinson's Diseases (AD/PD) and vice-versa. We evaluated whether a different distribution of known nongenetic risk factors for cancer and AD/PD, might explain their inverse relationship of occurrence. We nested 2 case-control studies in a subsample of a large cohort of 1,000,000 resident in Lombardy Region in Italy (n=1515), followed-up for cancer and AD/PD occurrence since 1991 until 2012. Conditional logistic regression was performed to determine the odds ratios (OR) and 95% confidence intervals (CI) of AD/PD in subjects with and witho...
Source: Alzheimer Disease and Associated Disorders - Category: Geriatrics Tags: Original Articles Source Type: research
ConclusionpRBD+ PD patients exhibited greater changes in non-motor symptoms. However, there was no increase in motor deficits.
Source: Translational Neurodegeneration - Category: Neurology Source Type: research
AbstractIncreasing metabolic syndromes including type-2 diabetes mellitus, obesity, and steatohepatitis are serious problems in most countries in the world. Neurodegenerative diseases such as Alzheimer, Parkinson ’s, and Huntington’s diseases are increasing in many countries. However, therapy for these diseases is not sufficient yet. Thus, effective chemotherapy for these diseases is being expected. Conophylline is an alkaloid isolated from the leaves ofErvatamia microphylla and related plants. It was found to induce beta-cell differentiation in the precursor pancreatic cells. Oral administration of this compou...
Source: Human Cell - Category: Cytology Source Type: research
In this study, we used the Clinical Practice Research Datalink (CPRD) to estimate clinically measured SBP and DBP trajectories for 20 years prior to death, for individuals dying at 60 years and older. Second, we compared the linear SBP trends for years 10 to 3 years before death in patients who died and age- and sex-matched controls who survived at least 9 years. These approaches aimed to separate age from end-of-life associations, and avoid healthy survivor biases. Twenty years before death, estimated mean SBPs increased with increasing age at death (60-69 years, 139.5 mm Hg; ≥90 years, 150.0 mm Hg). All age-at-...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Introduction: REM sleep behaviour disorder (RBD) is a REM parasomnia characterized by abnormal behaviours emerging during REM sleep in relation with unpleasant dreams. RBD can be classified as idiopathic (IRBD) when neurological disease, relevant motor or cognitive complaints do no exist, or secondary when it is associated with a neurological disorder the introduction of certain drugs or alcohol withdrawal. RBD can precede the onset of the motor or cognitive symptoms by several years and longitudinal studies have shown that most of patients diagnosed with IRBD develop the motor and cognitive features of a neurodegenerative...
Source: Sleep Medicine - Category: Sleep Medicine Authors: Tags: REM Behavior Disorders Source Type: research
Authors: Bassetti CL, Bargiotas P Abstract Rapid eye movement sleep behavior disorder (RBD) is a brain disorder, characterized by the dream enactment during rapid eye movement (REM) sleep due to a lack of physiologic muscle atonia and increased muscle twitching. Schenk was the first to describe this disorder in 1986; however, few authors reported in the 1970-1980s loss of physiological muscle atonia combined with dream enactment in the course of brainstem disorders and as a consequence of alcoholism and antidepressant treatment. RBD affects less than 1% of the adult population, but can be found in up to 25-50% of n...
Source: Frontiers of Neurology and Neuroscience - Category: Neuroscience Tags: Front Neurol Neurosci Source Type: research
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