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Delivery of brief interventions for heavy drinking in primary care: outcomes of the ODHIN 5-Country Cluster Randomized Trial - Anderson P, Coulton S, Kaner E, Bendtsen P, K łoda K, Reynolds J, Segura L, Wojnar M, Mierzecki A, Deluca P, Newbury-Birch D, Parkinson K, Okulicz-Kozaryn K, Drummond C, Gual A.

PURPOSE: We aimed to test whether 3 strategies-training and support, financial reimbursement, and an option to direct screen-positive patients to an Internet-based method of giving brief advice-have a longer-term effect on primary care clinicians' delivery...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

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Semin Neurol 2017; 37: 461-470 DOI: 10.1055/s-0037-1605595Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by loss of muscle atonia during REM sleep that allows motor responses to dream content. Patients display patterns of unusual, complex, and even violent motor activities. There is a high risk for harm to the patients or their bedpartners. REM sleep behavior disorder is more likely to occur in synucleinopathies such as Parkinson's disease, Lewy body dementia, and multiple system atrophy and may precede clinical manifestations by decades. In secondary RBD, brainstem centers involved in...
Source: Seminars in Neurology - Category: Neurology Authors: Tags: Review Article Source Type: research
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Source: Journal of Neurochemistry - Category: Neurology Authors: Tags: Original Article Source Type: research
Conclusions: In this study, we found no evidence that exposure to air pollution is a risk factor for PD in men. https://doi.org/10.1289/EHP259 Received: 01 April 2016 Revised: 07 November 2016 Accepted: 10 November 2016 Published: 18 August 2017 Address correspondence to N. Palacios, Dept. of Public Health, University of Massachusetts, Lowell; Lowell, Massachusetts. Telephone: 617-304-4254. Email: natalia_palacios@uml.edu Statistical analysis was done by N.P. and K.C.F. The authors declare they have no actual or potential competing financial interests. Note to readers with disabilities: EHP strives to ensu...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
Authors: Prinelli F, Adorni F, Leite MLC, Pettenati C, Russo A, Di Santo S, Musicco M Abstract Several studies reported that cancer is less frequent in persons with Alzheimer's and Parkinson's Diseases (AD/PD) and vice-versa. We evaluated whether a different distribution of known nongenetic risk factors for cancer and AD/PD, might explain their inverse relationship of occurrence. We nested 2 case-control studies in a subsample of a large cohort of 1,000,000 resident in Lombardy Region in Italy (n=1515), followed-up for cancer and AD/PD occurrence since 1991 until 2012. Conditional logistic regression was performed ...
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research
AbstractWe evaluated the possible association between head trauma and Parkinson ’s disease (PD). The FRAGAMP (Fattori di Rischio Ambientali e Genetici Associati alla Malattia di Parkinson) study is a large Italian multicenter case-control study carried out to evaluate the possible role of environmental and genetic factors in PD. Cases and controls were enrolled from six movem ent disorders centers located in the Central-Southern Italy. A standardized questionnaire was administered to record demographic, epidemiological, and clinical data. Positive history of head trauma was considered only if the head trauma preceded...
Source: Neurological Sciences - Category: Neurology Source Type: research
In this study, we asked how POD is influenced by different experimental practices and how likely it is that underpowered experiments lead to scientific disputes between two groups conducting identical experiments. To address these questions, we generated a parametric model based on the Gompertz equation using lifespan data of 5,026 C. elegans. We then used this model to simulate lifespan experiments with different conditions to determine how experimental parameters affect the ability to detect lifespan increases of certain sizes. We considered two important experimental features that contribute to the workload of lifespan ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
CONCLUSIONS: There is little or no increased suicide mortality following acute admissions for most physical illnesses. Much of the increased suicide mortality relates to gastrointestinal disorders that are often alcohol related or specific chronic conditions, which may be linked to side effects from certain therapeutic medications. Acute hospital admissions for physical illnesses may therefore provide an opportunity for targeted suicide prevention among people with certain conditions, particularly alcohol related disorders. PMID: 28714426 [PubMed - as supplied by publisher]
Source: Psychological Medicine - Category: Psychiatry Authors: Tags: Psychol Med Source Type: research
Conclusion There's a tendency when scientists announce a breakthrough in our understanding of a disease to immediately start thinking about whether this could lead to a cure. While the ultimate aim of research into Alzheimer's disease is of course to be able to prevent or treat it, early research like this is more about understanding the disease mechanisms. This piece of research demonstrates how a new technique can be used to identify the molecular structure of abnormal protein deposits in the brain. That's a big step forward for use of this technology, which may be useful for other diseases, too. The causes of Alzheimer...
Source: NHS News Feed - Category: Consumer Health News Tags: Neurology Source Type: news
Methamphetamine (METH) is a highly abused psychostimulant that is associated with an increased risk for developing Parkinson's disease (PD). This enhanced vulnerability likely relates to the toxic effects of METH that overlap with PD pathology, e.g., aberr...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
A 58-year-old man developed progressive walking difficulty over 10 years. He had normal development and an unremarkable birth history. At age 30, he developed bilateral drooping eyelids with double vision. At age 48, he developed progressive gait unsteadiness, slurred speech, and swallowing difficulty. At age 55, he needed to walk with a cane. He did not have seizures, hearing loss, or memory impairment. He did not have any history of alcohol abuse or exposures to anticonvulsants. His mother has congenital cardiac disease and diabetes mellitus, and his sister has had epilepsy since childhood. His daughter is healthy.
Source: Neurology - Category: Neurology Authors: Tags: Gait disorders/ataxia, Parkinson's disease/Parkinsonism, Eyelids, Diplopia (double vision), Mitochondrial disorders RESIDENT AND FELLOW SECTION Source Type: research
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