Toddler with liver cancer has triple organ transplant
Evie Mueller, from Iowa, was two when she was diagnosed with liver cancer in 2015. She got the all-clear in 2016 after chemo and surgery. But it came back and last week she had a triple transplant.
Conclusions: Factors found might contribute to Brazilian surveillance programs associated with decreased incidence of skin cancer.
ConclusionsTaken together, our observations indicate that regorafenib is beneficial in the treatment of patients with advanced HCC who progressed on or demonstrated intolerance to sorafenib therapy; however, careful selection and close monitoring of patients is necessary to maximize the benefit while minimizing the toxicities of regorafenib treatment.
Opinion statementThe era of hepatitis C virus (HCV) treatment with direct-acting antiviral (DAA) therapy has remarkably improved liver-related morbidity and overall mortality with patients achieving rapid and sustained clearance of HCV infection. The initial DAA clinical trials excluded patients with hepatitis B virus (HBV) co-infection, and thus potential complications were unforeseen until case reports of HBV reactivation associated with DAA therapy began to emerge. A recent United States Food and Drug Administration (FDA) drug safety communication has brought public attention to the issue of HBV reactivation in patients...
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Abstract BackgroundThe purpose of this study was to evaluate clinical characteristics, treatment, and survival of children, who were diagnosed with hepatoblastoma (HB) in their first 6 months of age, enrolled in the SIOPEL 2 and 3 protocols. MethodsSeventy‐nine patients, treated between 1994 and 2006, were analyzed after stratification into three age groups:
ConclusionsPatients with advanced HB treated with complex surgical resections with positive or close negative margins had good outcomes without OLT. We suggest that planned positive or close microscopic margins in highly selected HB patients may spare the morbidity of OLT and offer an alternative for those ineligible for OLT. Our experience illustrates the importance of a multidisciplinary team specialized in the management of liver tumors.
We have read with interest the review by Galle et al concerning the therapeutic strategy in intermediate stage hepatocellular carcinoma (HCC). The heterogeneity of this group is highlighted, whereas only transarterial chemoembolization (TACE) is recommended in the guidelines. However, some (Barcelona Clinic Liver Cancer) BCLC B patients may not benefit from TACE. Thus, in this review other therapeutic approaches are discussed, based on a very exhaustive review of the literature, from transplantation to the most recent systemic treatments such as immunotherapy.
Conclusion: The incorporation of 11C-choline PET/CT into the MDT discussion altered the diagnosis/treatment of one-third of HCC patients. We propose a novel diagnostic algorithm to be refined in referral centers for HCC management.
This study developed the first procedure for the removal of epithelium from the lung airway with the full preservation of vascular epithelium, which could be applied in vivo to treat diseases of lung epithelium. Whole lung scaffolds with an intact vascular network may also allow for recellularization using patient-specific cells and bioengineering of chimeric lungs for transplantation. In addition to the clinical potential, lung scaffolds lacking an intact epithelial layer but with functional vascular and interstitial compartments may also serve as a valuable physiological model for investigating (i) lung development, (ii)...
Authors: Usmani A, Mishra A, Ahmad M Abstract The liver is an imperative organ of tremendous importance concerned with maintenance of metabolic functions and detoxification of exogenous and endogenous challenges like xenobiotics, viral infections and chronic alcoholism. Liver diseases particularly hepatitis B virus infections, liver cirrhosis and hepatocellular carcinoma continue to pose a significant health challenge worldwide due to the lack of therapeutic management options besides liver resection and transplantation. Hepatocellular carcinoma (HCC) is the sixth most common cancer and the third leading cause of c...