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Diabetes Treatment Teaches Rogue Cells to Behave

'Stem cell educator' provided at least 4 years' benefit for some people with type 1 or type 2 diabetes, study says
Source: WebMD Health - Category: Consumer Health News Source Type: news

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Conclusions: Saliva contains molecular information worthy of interrogation via EWAS. The simplicity of specimen collection suggests that saliva offers a practical alternative to blood for measurements that can be used to characterize individual exposomes. https://doi.org/10.1289/EHP1011 Received: 23 August 2016 Revised: 08 November 2016 Accepted: 18 November 2016 Published: 20 July 2017 Address correspondence to V. Bessonneau, Silent Spring Institute, 320 Nevada St., Suite 302, Newton, Massachusetts 02460 USA. Telephone: (617) 332-4288. Email: vincent.bessonneau@gmail.com The authors declare they have no actual or po...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
'Stem cell educator' provided at least 4 years' benefit for some people with type 1 or type 2 diabetes, study says Source: HealthDay Related MedlinePlus Pages: Immune System and Disorders, Stem Cells
Source: MedlinePlus Health News - Category: Consumer Health News Source Type: news
Purpose of review: The genetic basis of type 1 diabetes (T1D) is being characterized through DNA sequence variation and cell type specificity. This review discusses the current understanding of the genes and variants implicated in risk of T1D and how genetic information can be used in prediction, intervention and components of clinical care. Recent findings: Fine mapping and functional studies has provided resolution of the heritable basis of T1D risk, incorporating novel insights on the dominant role of human leukocyte antigen (HLA) genes as well as the lesser impact of non-HLA genes. Evaluation of T1D-associated single ...
Source: Current Opinion in Endocrinology, Diabetes and Obesity - Category: Endocrinology Tags: DIABETES AND ENDOCRINE PANCREAS II: Edited by Peter A. Gottlieb Source Type: research
Publication date: Available online 12 July 2017 Source:Molecular Metabolism Author(s): Miriam Cnop, Sanna Toivonen, Mariana Igoillo-Esteve, Paraskevi Salpea Background Pancreatic β cell dysfunction and death are central in the pathogenesis of most if not all forms of diabetes. Understanding the molecular mechanisms underlying β cell failure is important to develop β cell protective approaches. Scope of review Here we review the role of endoplasmic reticulum stress and dysregulated endoplasmic reticulum stress signaling in β cell failure in monogenic and polygenic forms of diabetes. There is substantial...
Source: Molecular Metabolism - Category: Endocrinology Source Type: research
(Wiley) New research reveals that a treatment called Stem Cell Educator therapy is safe and effective for treating type 1 and type 2 diabetes.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Conclusion: Taken together, our findings indicate that As3MT acts to promote cardiovascular toxicity of arsenic and suggest that human AS3MT SNPs that correlate with enzyme function could predict those most at risk to develop atherosclerosis among the millions that are exposed to arsenic. https://doi.org/10.1289/EHP806 Received: 15 July 2016 Revised: 21 December 2016 Accepted: 21 December 2016 Published: 05 July 2017 Correspondence: K.K. Mann, Lady Davis Institute for Medical Research, McGill University, 3755 Cote Ste Catherine Rd., Montreal, QC, H3T 1E2 Canada; Telephone: (514) 340-8222 ext. 2760; Email: koren.mann@...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
Authors: Sackett SD, Rodriguez A, Odorico JS Abstract Diabetes, type 1 and type 2 (T1D and T2D), are diseases of epidemic proportions, which are complicated and defined by genetics, epigenetics, environment, and lifestyle choices. Current therapies consist of whole pancreas or islet transplantation. However, these approaches require life-time immunosuppression, and are compounded by the paucity of available donors. Pluripotent stem cells have advanced research in the fields of stem cell biology, drug development, disease modeling, and regenerative medicine, and importantly allows for the interrogation of therapeuti...
Source: Review of Diabetic Studies - Category: Endocrinology Tags: Rev Diabet Stud Source Type: research
Author Affiliations open 1Department of Preventive Medicine, School of Environmental Science and Public Health, Wenzhou Medical University, Wenzhou, Zhejiang, China 2Center on Clinical and Epidemiological Eye Research, Affiliated Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China 3Center on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA 4Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA 5Channing ...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
Type 1 and type 2 diabetes are caused by a destruction and decrease in the number of functional insulin‐producing β cells, respectively; therefore, the generation of functional β cells from human embryonic stem cells and human induced pluripotent stem cells, collectively known as human pluripotent stem cells (hPSCs), for potential cell replacement therapy and disease modelling is an intensely investigated area. Recent scientific breakthroughs enabled derivation of large quantities of human pancreatic β‐like cells in vitro, although with varied glucose‐stimulated insulin secretion kinetics. In the prese...
Source: Diabetes, Obesity and Metabolism - Category: Endocrinology Authors: Tags: REVIEW ARTICLE Source Type: research
AbstractSkeletal fragility often accompanies diabetes and does not appear to correlate with low bone mass or trauma severity in individuals with diabetes. Instead (and in contrast to those with osteoporotic bone disease), bone remodelling and bone turnover are compromised in both type 1 and type 2 diabetes, contributing to defective bone material quality. This review is one of a pair discussing the relationship between diabetes, bone and glucose-lowering agents; an accompanying review is provided in this issue ofDiabetologia by Ann Schwartz (DOI:10.1007/s00125-017-4283-6). This review presents basic science evidence that, ...
Source: Diabetologia - Category: Endocrinology Source Type: research
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