Predicting augmented renal clearance using estimated glomerular filtration rate in critically-ill children 
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Predicting augmented renal clearance using estimated glomerular filtration rate in critically-ill children
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Clin Nephrol. 2017 Jul 12;:
Authors: Lee B, Kim J, Park JD, Kang HM, Cho YS, Kim KS
Abstract
AIMS: Measured glomerular filtration rate (mGFR) is often used to identify augmented renal clearance (ARC). However, in the clinical setting, estimated GFR (eGFR) is obtained more quickly and inexpensively. We aimed to determine whether eGFR can identify ARC by evaluating the correlation between the eGFR and vancomycin trough level (VTL).
MATERIALS AND METHODS: We retrospectively reviewed the records of patients aged ≤ 18 years who underwent vancomycin therapeutic drug monitoring at our tertiary hospital from July 2009 to June 2014. VTL, serum creatinine concentration, eGFR, and clinical factors affecting VTL were analyzed.
RESULTS: Of 101 patients, 76 (75.25%) had a subtherapeutic VTL. Patient age (p = 0.006), the daily vancomycin dose (p = 0.041) and dosing interval (p = 0.006), and eGFR (p.
PMID: 28699888 [PubMed - as supplied by publisher]

Source: Clinical Nephrology - July 12, 2017 Category: Urology & Nephrology Authors: Lee B, Kim J, Park JD, Kang HM, Cho YS, Kim KS Tags: Clin Nephrol Source Type: research