Gambia: Who, Others Recognize Gambia's Accelerated Progress Towards Malaria Elimination
[Daily Observer] In The Gambia, the successes achieved in malaria prevention and control has been enormous and has been recognized both regionally and globally, says WHO Country Representative Professor Jean Marie Dangou.
This study describes differential subcellular localization of novel PHISTc members PFD1140w and PF11_0503 in infected erythrocytes and identifies their binding partners in an attempt to comprehend their functions in parasitized red blood cells. The research adds another chapter to the basic understanding of lethal malaria.
Abstract Marine environments are largely unexplored and can be a source of new molecules for the treatment of many diseases such as malaria, cancer, tuberculosis, HIV etc. The Marine environment is one of the untapped bioresource of getting pharmacologically active nonribosomal peptides (NRPs). Bioprospecting of marine microbes have achieved many remarkable milestones in pharmaceutics. Till date, more than 50% of drugs which are in clinical use belong to the nonribosomal peptide or mixed polyketide-nonribosomal peptide families of natural products isolated from marine bacteria, cyanobacteria and fungi. In recent y...
A drug resistant strain is spreading across Southeast Asia—and proposed cuts to the President’s Malaria Initiative won’t help -- Read more on ScientificAmerican.com
Abstract Dihydroartemisinin (DHA), either used in its own right or as the active drug generated in vivo from the other artemisinins in current clinical use-artemether and artesunate-induces quiescence in ring-stage parasites of Plasmodium falciparum (Pf). This induction of quiescence is linked to artemisinin resistance. Thus, we have turned to structurally disparate artemisinins that are incapable of providing DHA on metabolism. Accordingly, 11-azaartemisinin 5 and selected N-sulfonyl derivatives were screened against intraerythrocytic asexual stages of drug-sensitive Pf NF54 and drug-resistant K1 and W2 parasit...
In this study, the performance of the software for detection of malaria and calculation of parasitemia was evaluated and compared to microscopy (n=40). For CellaVision, both pre- and post-reclassification results were evaluated. Sensitivity was moderate, even post-reclassification (72%), due to low numbers of analyzed RBC and limited resolution of photographs.
(Weizmann Institute of Science) The new study suggest a possible defense in the battle against this deadly disease.
Global travel continues to increase, particularly to tropical destinations that have different health risks from those encountered closer to home. Currently, over a billion people travel annually, with over 65 million visits made from the UK. Seeking pre-travel advice should be an essential part of any trip for a traveller. The key elements of pre-travel advice are health risk assessment, health promotion and risk management; this involves advice on prevention of malaria, travellers' diarrhoea, sexually transmitted infections and accidents, as well as appropriate vaccinations.