Gambia: Who, Others Recognize Gambia's Accelerated Progress Towards Malaria Elimination

[Daily Observer] In The Gambia, the successes achieved in malaria prevention and control has been enormous and has been recognized both regionally and globally, says WHO Country Representative Professor Jean Marie Dangou.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news

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(Imperial College London) Using two experimental anti-malarial vaccines, which work in different ways, can greatly reduce the number of malaria infections in animal studies.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Anti-malarial pre-erythrocytic vaccines (PEV) target transmission by inhibiting human infection but are currently partially protective. It has been posited, but never demonstrated, that co-administering transmission-blocking vaccines (TBV) would enhance malaria control. We hypothesized a mechanism that TBV could reduce parasite density in the mosquito salivary glands, thereby enhancing PEV efficacy. This was tested using a multigenerational population assay, passagingPlasmodium berghei toAnopheles stephensi mosquitoes. A combined efficacy of 90.8% (86.7 –94.2%) was observed in the PEV +TBV antibody group, higher than...
Source: eLife - Category: Biomedical Science Tags: Epidemiology and Global Health Microbiology and Infectious Disease Source Type: research
Semin Thromb Hemost DOI: 10.1055/s-0038-1657778Thrombocytopenia is a well-known manifestation of acute tropical infectious diseases. The role of platelets in infections has received much attention recently because of their emerging activities in modulation of inflammatory responses, host defense, and vascular integrity. However, while many studies have addressed thrombocytopenia in tropical infections, abnormalities in platelet function have been largely overlooked. This is an important research gap, as platelet dysfunction may contribute to the bleeding tendency that characterizes some tropical infections. The development...
Source: Seminars in Thrombosis and Hemostasis - Category: Hematology Authors: Tags: Review Article Source Type: research
Conclusion: Tropical diseases like malaria, dengue, and leptospirosis were the main factors responsible for ARDS. LIS, Modified LIS and PaO2/FiO2 ratio predicted outcome as well as need for mechanical ventilation. Renal failure, metabolic acidosis appeared to be good predictors of mortality. PMID: 29897698 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
AbstractPurpose of ReviewIn the last 25  years, child mortality has significantly dropped at a global level. Understanding particularities of child mortality at the national level is useful to tailor health policy to those conditions requiring more attention. In Mozambique, a variety of efforts have been made to better characterize the o verall child mortality and to describe the main contributors for death. In this review, we attempt to contextualize current knowledge on causes of pediatric deaths in Mozambique.Recent FindingsThe available data regarding the principal causes of death in Mozambican children point out ...
Source: Current Tropical Medicine Reports - Category: Tropical Medicine Source Type: research
[Royal Academy of Engineering] London -A 24-year-old Ugandan software engineer has won the Africa Prize for Engineering Innovation. Brian Gitta is the first Ugandan to win the prestigious Africa Prize, and the youngest winner to date.
Source: AllAfrica News: Malaria - Category: Infectious Diseases Source Type: news
Chemical Research in ToxicologyDOI: 10.1021/acs.chemrestox.7b00285
Source: Chemical Research in Toxicology - Category: Toxicology Authors: Source Type: research
Publication date: 15 October 2018 Source:Biosensors and Bioelectronics, Volume 117 Author(s): Naveen K. Singh, Sunil K. Arya, Pedro Estrela, Pranab Goswami A capacitive aptasensor for detecting the malaria biomarker, Plasmodium falciparum glutamate dehydrogenase (PfGDH), directly in human serum samples developed. A thiolated ssDNA aptamer (NG3) that binds specifically to PfGDH antigen with high affinity (K d = 79 nM) was used to develop the aptasensor. The aptasensor produced capacitance response at an optimized frequency of 2 Hz in a non-Faradaic electrochemical impedance based signal transduction platform. The aptas...
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
Systemic lupus erythematosus (SLE) is an autoimmune disease whose etiology and pathogenesis are incompletely understood. Over the past 50-60 years, there has been a rise of more than ten-fold in the annual incidence of SLE in industrialized Western countries. Although it is believed that the etiology of SLE is multifactorial, including genetic, hormonal and environmental triggers, the molecular mechanisms underlying this systemic autoimmune response remain largely unknown. Clinical and epidemiological studies have revealed that SLE is rarely observed in rural tropical areas of Africa and Asia, where parasitic infections ar...
Source: Current Immunology Reviews - Category: Allergy & Immunology Source Type: research
by Lou S. Herman, Kimberly Fornace, Jody Phelan, Matthew J. Grigg, Nicholas M. Anstey, Timothy William, Robert W. Moon, Michael J. Blackman, Chris J. Drakeley, Kevin K. A. Tetteh BackgroundPlasmodium knowlesi is the most common cause of malaria in Malaysian Borneo, with reporting limited to clinical cases presenting to health facilities and scarce data on the true extent of transmission. Serological estimations of transmission have been used with other malaria species to garner information about epidemiological patterns. However, there are a distinct lack of suitable serosurveillance tools for this neglected disease. Metho...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
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