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TBI and dementia: Link or no link?

Research linking traumatic brain injury and dementia later in life is contradictory. Learn about the latest findings and what they mean for TBI patients.
Source: Parkinson's Disease News From Medical News Today - Category: Neurology Tags: Alzheimer's / Dementia Source Type: news

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Conclusions: Dementia with Lewy bodies patients may harbor 18F‐AV‐1451 binding patterns distinct from Alzheimer's disease, with greater involvement of the primary cortices and less involvement of the temporal cortex. Tau burden increases in the Lewy body disease spectrum, and amyloid may play an important role in the accumulation of neocortical tau in Lewy body diseases. © 2017 International Parkinson and Movement Disorder Society
Source: Movement Disorders - Category: Neurology Authors: Tags: Research Article Source Type: research
The objective of this study was to find baseline predictors of cognitive decline in longitudinally followed, nondemented Parkinson's disease patients. MethodsWe performed a prospective cohort study of 100 PD patients with a median disease duration of 6.4 years. All participants were nondemented at baseline. We examined 16 baseline biomarkers from clinical, genetic, biochemical, and MRI‐based imaging modalities for their association with longitudinal cognitive decline for up to 8 years. We investigated biomarkers individually, as well as in a multivariate linear mixed‐effects model encompassing multimodal biomarkers, wi...
Source: Movement Disorders - Category: Neurology Authors: Tags: Research Article Source Type: research
Scientists use cutting-edge technology to show how Lewy body dementia affects more than 1 million synapses, the tiny connections between neurons.
Source: Parkinson's Disease News From Medical News Today - Category: Neurology Tags: Alzheimer's / Dementia Source Type: news
Conclusions: Autonomic function tests might be quite useful to distinguish DLB and PDD from AD.Eur Neurol 2018;79:27 –32
Source: European Neurology - Category: Neurology Source Type: research
Abstract OVERVIEW: MicroRNAs (miRNAs) have been implicated in neurodegenerative diseases including Parkinson's disease and Alzheimer's disease (AD). Here, we evaluated the expression of miRNAs in anterior cingulate (AC; Brodmann area [BA] 24) and primary motor (MO; BA 4) cortical tissue from aged human brains in the University of Kentucky AD Center autopsy cohort, with a focus on dementia with Lewy bodies (DLB). METHODS: RNA was isolated from gray matter of brain samples with pathology-defined DLB, AD, AD+DLB, and low-pathology controls, with n=52 cases initially included (n=23 with DLB), all with low (
Source: Brain Research - Category: Neurology Authors: Tags: Brain Res Source Type: research
Publication date: Available online 13 November 2017 Source:Clinica Chimica Acta Author(s): Paul L. Wood, John E. Cebak, Randall L. Woltjer Cognitive decline is a devastating clinical condition, heavily correlated with age progression. In the cases of Alzheimer's disease, Parkinson's disease, and Lewy body disease, the common neuropathologies are proteinopathies and neuroinflammation. Herein, we review current lipidomics findings and conclude that brain and circulating diacylglycerols represent biomarkers of this ongoing sustained immune response, presumably involving microglia. We further hypothesize that a logical next s...
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
Abstract Cognitive decline is a devastating clinical condition, heavily correlated with age progression. In the cases of Alzheimer's disease, Parkinson's disease, and Lewy body disease, the common neuropathologies are proteinopathies and neuroinflammation. Herein, we review current lipidomics findings and conclude that brain and circulating diacylglycerols represent biomarkers of this ongoing sustained immune response, presumably involving microglia. We further hypothesize that a logical next step will be to evaluate biomarkers of immune activation in a cohort of patients with Mild Cognitive Impairment (MCI) and s...
Source: International Journal of Clinical Chemistry - Category: Chemistry Authors: Tags: Clin Chim Acta Source Type: research
Conclusion: The overall compliance of the DAT imaging with the existing standard guidelines was good. DAT scan can be very useful in clinical practice because it influences the clinical diagnosis and management in 23% of the patients.
Source: Neurology India - Category: Neurology Authors: Source Type: research
This article presents a systematic review of ALSP in the context of two illustrative cases to help integrate the literature on HDLS and POLD. Consistent use of the term ALSP is suggested for clarity in the literature going forward.
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
The different memory systems of the brain -- episodic, semantic, procedural, and working -- and how they are affected by Alzheimer's disease.Seven Stages of Alzheimer's diseaseBy Alzheimer's Reading RoomThehuman brain contains an estimated 100 billion nerve cells (neurons).Chemical and electrical activity allows these neurons to perform their tasks and to communicate with one another.This elaborate communication system controls vital body functions and enables us to think, see, move, talk, remember, and experience emotions.What ’s the Difference Between Alzheimer’s and DementiaHow Memory Is Affected in Alzheime...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: alzheimer's awareness alzheimer's care Alzheimer's Dementia care of dementia patients at home how does alzheimer's affect brain searches related to memory Source Type: blogs
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