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TBI and dementia: Link or no link?

Research linking traumatic brain injury and dementia later in life is contradictory. Learn about the latest findings and what they mean for TBI patients.
Source: Parkinson's Disease News From Medical News Today - Category: Neurology Tags: Alzheimer's / Dementia Source Type: news

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In conclusion, the 2‐benzylidene‐1‐tetralone derivatives can be considered as lead compounds to design a new class of dual acting adenosine A1/A2A receptor antagonists that may have potential in treating both dementia and locomotor deficits in Parkinson's disease. This article is protected by copyright. All rights reserved. Substitution of 2‐benzylidene‐1‐tetralone with a hydroxy group on ring A and/or B played a key role in modulating the binding affinity and selectivity for the adenosine A1 and A2A receptors. Generally, C5‐hydroxy substitution on ring A favored A1 affinity, while C4′‐hydroxy substi...
Source: Chemical Biology and Drug Design - Category: Biology Authors: Tags: Research Article Source Type: research
This article is part of a Special Issue entitled Neuro-glycoscience, edited by Kenji Kadomatsu and Hiroshi Kitagawa. Graphical abstract
Source: Biochimica et Biophysica Acta (BBA) General Subjects - Category: Biochemistry Source Type: research
Mutations in LRRK2, which encodes leucine-rich repeat kinase 2, are the most common genetic cause of familial and sporadic Parkinson’s disease (PD), a degenerative disease of the central nervous system that causes impaired motor function and, in advanced stages, dementia. Dementia is a common symptom of another neurodegenerative disease, Alzheimer’s disease, and research suggests that there may be pathophysiological and genetic links between the two diseases. Aggregates of β amyloid [a protein produced through cleavage of amyloid precursor protein (APP)] are seen in both diseases and in PD patients carryin...
Source: Signal Transduction Knowledge Environment - Category: Science Authors: Tags: STKE Research Articles Source Type: news
Abstract Mutations in LRRK2, which encodes leucine-rich repeat kinase 2, are the most common genetic cause of familial and sporadic Parkinson's disease (PD), a degenerative disease of the central nervous system that causes impaired motor function and, in advanced stages, dementia. Dementia is a common symptom of another neurodegenerative disease, Alzheimer's disease, and research suggests that there may be pathophysiological and genetic links between the two diseases. Aggregates of β amyloid [a protein produced through cleavage of amyloid precursor protein (APP)] are seen in both diseases and in PD patients c...
Source: Science Signaling - Category: Biomedical Science Authors: Tags: Sci Signal Source Type: research
Conclusions: This study demonstrates that neurologic patients have a high proportion of AEs in hospital. The findings provide information on the quality and safety of care for people with neurologic conditions in hospital, which can help inform future quality improvement initiatives.
Source: Neurology - Category: Neurology Authors: Tags: All Health Services Research, Medical care, All Clinical Neurology, Patient safety ARTICLE Source Type: research
CONCLUSIONS: S-adenosylmethionine holds promise as a treatment for multiple neuropsychiatric conditions, but the body of evidence has limitations. The encouraging findings support further study of SAMe in both psychiatric and comorbid medical illnesses. PMID: 28682528 [PubMed - in process]
Source: Journal of Clinical Psychiatry - Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
This article is protected by copyright. All rights reserved.
Source: Experimental Dermatology - Category: Dermatology Authors: Tags: Review Article Source Type: research
The Dementia with Lewy Bodies (DLB) Consortium has refined its recommendations about the clinical and pathologic diagnosis of DLB, updating the previous report, which has been in widespread use for the last decade. The revised DLB consensus criteria now distinguish clearly between clinical features and diagnostic biomarkers, and give guidance about optimal methods to establish and interpret these. Substantial new information has been incorporated about previously reported aspects of DLB, with increased diagnostic weighting given to REM sleep behavior disorder and 123iodine-metaiodobenzylguanidine (MIBG) myocardial scintigr...
Source: Neurology - Category: Neurology Authors: Tags: Dementia with Lewy bodies, Parkinson's disease with dementia, Assessment of cognitive disorders/dementia VIEWS & amp;amp; REVIEWS Source Type: research
Every caregiver of a person living with Alzheimer's, Lewy Body dementia, Parkinson's or any other related dementia faces this gut wrenching question -Should I put my loved with dementia in a nursing home or memory care facility?By Bob DeMarcoAlzheimer's Reading RoomWe all face this gut wrenching decision. Most of us don't want to do it. But sometimes, it is the only decision, and only right decision.There are a long list of reasons why you might have to place your loved one in a nursing home or long term care memory facility.Topic -Dementia CareLet me start by making this clear -it is not your fault.It is not your fault th...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: alzheimer's care facilities care of dementia patients caregiver dementia care elderly dementia care help alzheimer's help with dementia care memory care facilities memory care facility nursing home Source Type: blogs
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - Category: Neuroscience Authors: Tags: Review Source Type: research
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