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TBI and dementia: Link or no link?

Research linking traumatic brain injury and dementia later in life is contradictory. Learn about the latest findings and what they mean for TBI patients.
Source: Parkinson's Disease News From Medical News Today - Category: Neurology Tags: Alzheimer's / Dementia Source Type: news

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Pimavanserin is an atypical antipsychotic marketed in the USA for hallucinations and delusions associated with Parkinson's disease.1 It acts as an inverse agonist at the 5-HT2A receptor with no effect on dopamine receptors. A boxed warning on the prescribing information approved by the US Food and Drug Administration states that pimavanserin is not approved for elderly patients with dementia-related psychosis unrelated to Parkinson's disease psychosis, and that these patients are at increased risk of death when treated with antipsychotics.
Source: Lancet Neurology - Category: Neurology Authors: Tags: Comment Source Type: research
In conclusion, most experimental data on immune changes with aging show a decline in many immune parameters when compared to young healthy subjects. The bulk of these changes is termed immunosenescence. Immunosenescence has been considered for some time as detrimental because it often leads to subclinical accumulation of pro-inflammatory factors and inflammaging. Together, immunosenescence and inflammaging are suggested to stand at the origin of most of the diseases of the elderly, such as infections, cancer, autoimmune disorders, and chronic inflammatory diseases. However, an increasing number of gerontologists have chall...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
(NIH/National Institute of Allergy and Infectious Diseases) NIH scientists have modified a test for early diagnosis of prion diseases with the goal of improving early diagnosis of Parkinson's disease and dementia with Lewy bodies. The NIAID-led group tested cerebral spinal fluid samples from people with Parkinson's disease; people with dementia with Lewy bodies; and controls, some of whom had Alzheimer's disease. The test correctly excluded all the controls and diagnosed both Parkinson's disease and dementia with Lewy bodies with 93 percent accuracy.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
ConclusionResults support the usefulness and sensitivity of the CDT in the detection of different dementia subtypes. Qualitative error analysis of the CDT may be helpful in differentiating PD, VaD, and AD, even in the early stages of each disease.
Source: Psychogeriatrics - Category: Geriatrics Authors: Tags: ORIGINAL ARTICLE Source Type: research
In this study, we aim to compare the concurrence of VRFs of Lewy body dementia (LBD) to AD. Materials &MethodsWe consecutively enrolled patients with dementia with Lewy bodies (DLB), Parkinson's disease dementia (PDD), and AD, and the prevalence of arterial hypertension, diabetes mellitus, hypercholesterolemia, hyperlipidemia, smoking, and obesity was assessed and compared. ResultsA total of 167 consecutive patients were studied. Among them, 55 had DLB, 34 had PDD, and 78 had AD. History of any VRF among three groups was not significantly different. In addition, the patients with AD had significantly higher systolic pr...
Source: Brain and Behavior - Category: Neurology Authors: Tags: ORIGINAL RESEARCH Source Type: research
DISCUSSION: Increased NFL levels are a common feature in neurodegenerative dementias. PMID: 29391125 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
Discussion Increased NFL levels are a common feature in neurodegenerative dementias.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
Purpose of review This narrative review aims to highlight recent findings on the relation between uric acid level and cognitive decline or dementia. Recent findings The antioxidant properties of uric acid, which have supported the hypothesis that uric acid may be neuroprotective, have been questioned by preclinical data. Studies investigating the relation between serum uric acid (SUA) level and Alzheimer disease are mostly cross-sectional, and results are often inconclusive. Similarly, data for an association between uric acid level and cognitive performance are inconsistent. There is some evidence that low SUA level ...
Source: Current Opinion in Rheumatology - Category: Rheumatology Tags: CRYSTAL DEPOSITION DISEASES: Edited by Ann K. Rosenthal Source Type: research
New help may be on the way for people with dementia with Lewy bodies, which is the second most common neurodegenerative type of dementia after Alzheimer ’s disease.by Alzheimer's Reading RoomThe disease can cause movement problems and issues such ashallucinations in addition to thinking and memory problems. But the drug used to treat the movement problems can also exacerbate the hallucinations, delusions and other psychiatric problems.Lewy Body Dementia is not a rare disease.It affects an estimated 1.4 million individuals and their families in the United States. Because LBD symptoms can closely resemble other mo...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: health LBD lewy bodies Lewy Body Dementia life news Parkinson ’s drug treatment Source Type: blogs
In conclusion, the present study demonstrated that TIGIT is a prominent negative immune regulator involved in immunosenescence. This novel finding is highly significant, as targeting TIGIT might be an effective strategy to improve the immune response and decrease age-related comorbidities. Delivery of Extracellular Vesicles as a Potential Basis for Therapies https://www.fightaging.org/archives/2018/01/delivery-of-extracellular-vesicles-as-a-potential-basis-for-therapies/ Here I'll point out a readable open access review paper on the potential use of extracellular vesicles as a basis for therapy: harveste...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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