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Researchers identify visual system changes that may signal Parkinson's disease

Changes in the visual systems of newly diagnosed Parkinson's disease patients may provide important biomarkers for the early detection and monitoring of the disease, according to a new study...
Source: Parkinson's Disease News From Medical News Today - Category: Neurology Tags: Parkinson's Disease Source Type: news

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Mobile eye-trackers are currently used during real-world tasks (e.g. gait) to monitor visual and cognitive processes, particularly in ageing and Parkinson's disease (PD). However, contextual analysis involving fixation locations during such tasks is rarely...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
The objective of this study was to study the relationship between the PD‐related pattern, dopamine transporter binding, and olfaction in idiopathic REM sleep behavior disorder. MethodsIn this cross‐sectional study, 21 idiopathic REM sleep behavior disorder subjects underwent 18F‐fluorodeoxyglucose PET, dopamine transporter imaging, and olfactory testing. For reference, we included 18F‐fluorodeoxyglucose PET data of 19 controls, 20 PD patients, and 22 patients with dementia with Lewy bodies. PD‐related pattern expression z‐scores were computed from all PET scans. ResultsPD‐related pattern expression was higher...
Source: Movement Disorders - Category: Neurology Authors: Tags: Brief Report Source Type: research
In conclusion, the 2‐benzylidene‐1‐tetralone derivatives can be considered as lead compounds to design a new class of dual acting adenosine A1/A2A receptor antagonists that may have potential in treating both dementia and locomotor deficits in Parkinson's disease. This article is protected by copyright. All rights reserved. Substitution of 2‐benzylidene‐1‐tetralone with a hydroxy group on ring A and/or B played a key role in modulating the binding affinity and selectivity for the adenosine A1 and A2A receptors. Generally, C5‐hydroxy substitution on ring A favored A1 affinity, while C4′‐hydroxy substi...
Source: Chemical Biology and Drug Design - Category: Biology Authors: Tags: Research Article Source Type: research
The Michael J. Fox Foundation for Parkinson’s Research and the Center for the Advancement of Science in Space yesterday inked a collaboration to send a protein linked to Parkinson’s disease to the International Space Station. The researchers plan to evaluate the protein’s growth under microgravity conditions, which could foster larger, more regular LRRK2 protein crystals to grow and give insight into the protein’s structure. A better understanding of LRRK2’s structure could help design therapies optimized against the protein. Get the full story at our sister site, Drug Delivery Business News. ...
Source: Mass Device - Category: Medical Devices Authors: Tags: Neurological Pharmaceuticals Research & Development Wall Street Beat Source Type: news
Notice NOT-NS-17-036 from the NIH Guide for Grants and Contracts
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
Publication date: Available online 21 July 2017 Source:International Review of Neurobiology Author(s): Robin Fackrell, Jon Hiseman Parkinson's disease has traditionally been considered as primarily a motor disorder (Chaudhuri & Schapira, 2009). It is clear however that it is the burden of the nonmotor symptomatology which impacts significantly more highly on caregiver burden and quality of life (Benavides, Alberquerque, & Chana-Cuevas, 2013; Martinez-Martin, 2011). As Parkinson's disease advances there is an almost inevitable accrual of nonmotor symptoms alongside the motor aspects of the disease. Patients as thei...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
Publication date: Available online 21 July 2017 Source:International Review of Neurobiology Author(s): Anette Schrag, Raquel N. Taddei Depression and anxiety are some of the most common comorbidities arising in patients with Parkinson's disease. However, their timely recognition and diagnosis are often hindered by overlap with other somatic features and a low rate of self-report. There is a need for greater awareness and for better assessment and treatment options are highly required. Currently available scales can serve as tools to monitor change over time and the effect of interventional strategies. Development of new t...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
Conclusion We conclude that the proposed methods are suitable for automatic MER denoising and may help in the efficient elimination of undesirable signal artifacts. Graphical abstract Highlights
Source: Journal of Neuroscience Methods - Category: Neuroscience Source Type: research
ABSTRACT The 12‐item Short Form Health Survey (SF‐12) is a generic health rating scale developed to reproduce the Physical and Mental Component Summary scores (PCS and MCS, respectively) of a longer survey, the SF‐36. The standard PCS/MCS scoring algorithm has been criticized because its expected dimensionality often lacks empirical support, scoring is based on the assumption that physical and mental health are uncorrelated, and because scores on physical health items influence MCS scores, and vice versa. In this paper, we review the standard PCS/MCS scoring algorithm for the SF‐12 and consider alternative scoring ...
Source: Research in Nursing and Health - Category: Nursing Authors: Tags: RESEARCH ARTICLE Source Type: research
Distinct motor subtypes of Parkinson's disease (PD) have been described through both clinical observation and through data-driven approaches. However, the extent to which motor subtypes change during disease progression remains unknown. Our objective was to determine motor subtypes of PD using an unsupervised clustering methodology and evaluate subtype changes with disease duration.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Source Type: research
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