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Researchers identify visual system changes that may signal Parkinson's disease

Changes in the visual systems of newly diagnosed Parkinson's disease patients may provide important biomarkers for the early detection and monitoring of the disease, according to a new study...
Source: Parkinson's Disease News From Medical News Today - Category: Neurology Tags: Parkinson's Disease Source Type: news

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A new 'tele-empathy' device allows Pat Smerdon of Vancouver to experience the same Parkinson's tremors that his twin brother, Jim, struggles with every day.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Conditions:   Parkinson Disease;   Surgery Interventions:   Procedure: Neural implantation group;   Procedure: Sham surgery Sponsor:   University of Denver Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
US civil rights activist Jesse Jackson disclosed that he has been diagnosed with Parkinson ’s disease. Unfortunately for Jackson, and more than 10 million worldwide living with Parkinson's, there's no cure. However, a new partnership between AstraZeneca and Berg believes AI will be able to prevent it
Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Tags: NASDAQ:AZN NASDAQ:BERG NASDAQ:GSK Source Type: news
(Reuters) - Acorda Therapeutics Inc said on Monday it would stop developing its Parkinson's disease drug, less than a week after the company reported deaths in key studies testing the treatment.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Previous postmortem studies demonstrated dysregulation of autophagy in patients with Parkinson's disease (PD). To clarify whether this alteration reflects a fundamental aspect of PD or represents the final stage of autophagy dysregulation resulting from a long neurodegenerative process, we focused on basal autophagy in peripheral blood mononuclear cells (PBMCs) of PD patients (n = 35) and controls (n = 23). The whole-transcriptome assay revealed down-regulation of mRNAs for six core regulators of autophagy (UNC-51-like kinase (ULK) 3, autophagy-related (Atg) 2A, Atg4B, Atg5, Atg16L1, histone deacetylase 6).
Source: Neurobiology of Aging - Category: Neuroscience Authors: Source Type: research
Ghrelin, a 28-amino acid peptide hormone, has protective effects on neuronal cells. The present study aimed to examine the neuroprotective effects of ghrelin on the rat retinal ganglion cells in the rotenone-induced in vitro model of Parkinson's disease (PD). Cell viability and cell apoptosis were determined by MTT assay and flow cytometry, respectively. Mitochondrial functions were detected by mitochondrial complex I activity assay and mitochondrial membrane potential (MMP) assay. The mRNA and protein expression levels were determined by qRT-PCR and western blot, respectively.
Source: Neuropeptides - Category: Neuroscience Authors: Source Type: research
Authors: Béreau M Abstract Little is known about the neurological control of human sexual behavior. Investigating and measuring this behavior by using quantitative and objective methods is difficult. Insights from lesion studies contribute to analyze the effects of neurological disorders on human sexual behavior. In this chapter, we focus on frontal lobe lesions, brain injuries, epilepsia, dementia, and Parkinson disease to describe human sexual behavior disorders, in order to highlight cortical and subcortical brain regions and neural networks involved in human sexual behavior. PMID: 29145185 [PubMed - in process]
Source: Frontiers of Neurology and Neuroscience - Category: Neuroscience Tags: Front Neurol Neurosci Source Type: research
Authors: Bassetti CL, Bargiotas P Abstract Rapid eye movement sleep behavior disorder (RBD) is a brain disorder, characterized by the dream enactment during rapid eye movement (REM) sleep due to a lack of physiologic muscle atonia and increased muscle twitching. Schenk was the first to describe this disorder in 1986; however, few authors reported in the 1970-1980s loss of physiological muscle atonia combined with dream enactment in the course of brainstem disorders and as a consequence of alcoholism and antidepressant treatment. RBD affects less than 1% of the adult population, but can be found in up to 25-50% of n...
Source: Frontiers of Neurology and Neuroscience - Category: Neuroscience Tags: Front Neurol Neurosci Source Type: research
Authors: Wagle Shukla A, Zeilman P, Fernandez H, Bajwa JA, Mehanna R Abstract Deep brain stimulation (DBS) surgery is a well-established therapy for control of motor symptoms in Parkinson's disease. Despite an appropriate targeting and an accurate placement of DBS lead, a thorough and efficient programming is critical for a successful clinical outcome. DBS programming is a time consuming and laborious manual process. The current approach involves use of general guidelines involving determination of the lead type, electrode configuration, impedance check, and battery check. However there are no validated and well-es...
Source: Parkinsons Disease - Category: Neurology Tags: Parkinsons Dis Source Type: research
Authors: Jonasson SB, Hagell P, Hariz GM, Iwarsson S, Nilsson MH Abstract Objective: To evaluate a set of psychometric properties (i.e., data completeness, targeting, and external construct validity) of the Parkinson's disease Activities of Daily Living Scale (PADLS) in people with Parkinson's disease (PD). Specific attention was paid to the association between PADLS and PD severity, according to the Hoehn &Yahr (H&Y) staging. Methods: The sample included 251 persons with PD (mean age 70 [SD 9] years). Data collection comprised a self-administered postal survey, structured interviews, and clinical assessmen...
Source: Parkinsons Disease - Category: Neurology Tags: Parkinsons Dis Source Type: research
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