Myelination of axons emerging from neural progenitor grafts after spinal cord injury.
Myelination of axons emerging from neural progenitor grafts after spinal cord injury. Exp Neurol. 2017 Jul 08;: Authors: Hunt M, Lu P, Tuszynski MH Abstract Neural progenitor cells (NPCs) grafted to sites of spinal cord injury (SCI) extend numerous axons over long distances and form new synaptic connections with host neurons. In the present study we examined the myelination of axons emerging from NPC grafts. Rat E14 multipotent NPCs constitutively expressing GFP were grafted into adult C5 spinal cord hemisection lesions; 3months later we examined graft-derived axonal diameter and myelination using transmission electron microscopy. 104 graft-derived axons were characterized. Axon diameter ranged from 0.15 to 1.70μm, and 24% of graft-derived axons were myelinated by host oligodendrocytes caudal to the lesion. The average diameter of myelinated axons (0.72±0.06μm) was significantly larger than that of non-myelinated axons (0.61±0.03μm, p
Publication date: Available online 20 October 2019Source: Life SciencesAuthor(s): Shutao Gao, Tao Xu, Hailong Guo, Qiang Deng, Chuanhui Xun, Weidong Liang, Weibin ShengAbstractAimsThe activation of NLRP3 inflammasome, which initiates an inflammatory cascade and triggers inflammatory death, plays a crucial role in the pathogenesis of spinal cord injury (SCI). Echinacoside (ECH) is a phenylethanoid glycoside possessing prominent anti-inflammatory effects and various neuroprotective properties in the central nervous system, but the effect of ECH on SCI was rarely studied. Therefore, the purpose of this experiment was to look ...
Condition: Spinal Cord Injuries Intervention: Device: transcutaneous spinal cord stimulation Sponsors: The Neurokinex Charitable Trust; International Spinal Research Trust Not yet recruiting
This study describes a single experience of SCI prevention in patients who have had endovascular repair.
This report illustrates a patient with Loeys–Dietz syndrome treated who presented with a symptomatic intercostal artery (IA) patch aneurysm following open surgical TAAA repair.
Conclusion: The use of the Seal thoracic stent graft yielded good mid-term results. Further studies are needed to examine the long-term outcomes of this device. PMID: 31624711 [PubMed]
The occurrence of mechanical impingement during certain manual wheelchair tasks, even without increased load/resistance, demonstrates the importance of kinematics inherent to a task as a determinant of impingement. Frequency of and technique used to complete daily tasks should be carefully considered to reduce impingement risk, which may help preserve shoulder health long-term.
The greatest effect of increasing maneuver speed occurred during the Setup step; as speed increased, participants reduced their minimum lateral margin of stability ipsilateral to the maneuver direction. This action allowed maneuvers to be performed more quickly without requiring a greater lateral impulse during the Pushoff step. However, this strategy reduced passive stability.
Over the last 5 years multiple stakeholders in the field of spinal cord injury (SCI) research have initiated efforts to promote publications standards and to enable sharing of experimental data. In 2016 NIH/NINDS hosted representatives from the SCI communi...
ConclusionBrazilein inhibits PSD-95 activation in the corresponding segment of sciatic nerve spinal cord in BALB/c mice after sciatic nerve injury, thereby inhibiting the excessive expression of free radicals and promoting myelin regeneration.
ConclusionThese data indicate a strong association between temporal changes of the Se and Cu status and the clinical outcome after TSCI. The dynamics observed may reflect an ongoing redistribution of the trace elements in favor of a better anti-inflammatory response and a more successful neurological regeneration.