Morphosys jumps as FDA approves psoriasis drug
FRANKFURT (Reuters) - Shares in Morphosys jumped 9 percent on Friday after a licensee won U.S. approval for psoriasis drug guselkumab, bringing the German biotech group a step closer to launching its first antibody drug on to the market.
Discussion Fats and fatty acids are essential for good human health. Saturated fats have hydrogen pairs linked to each carbon on the carbon backbone. They are solid or semi-solid at room temperature. Common examples are butter, lard, or hardened vegetable shortening. They are linked to higher cholesterol and triglycerides and only a small amount of them are recommended to be consumed in the diet. Unsaturated fats have one or more hydrogen atoms missing from the carbon backbone. They are liquid at room temperature. Monounsaturated fatty acids have one hydrogen pair that is missing from the carbon backbone. They are liq...
Psoriasis is a long-term condition that causes excess skin cells to form inflamed or scaly patches on the skin. Can aloe vera help manage the symptoms?
CONCLUSIONS: The SiPAS questionnaire is able to quickly screen psoriasis patients for PsA. A SiPAS score ≥3 is an indication for referral to a rheumatologist. The SiPAS needs further validation. PMID: 29148421 [PubMed - as supplied by publisher]
Authors: Abji F, Pollock RA, Liang K, Chandran V, Gladman DD Abstract OBJECTIVES: The IL-23/IL-17 axis is central to the pathogenesis of psoriatic arthritis (PsA). We aimed to identify Th17 signalling genes that are dysregulated in synovial fluid of PsA compared to osteoarthritis (OA) patients and to determine if differences in peripheral blood can distinguish PsA from psoriasis patients and controls. METHODS: Synovial fluid cells (SFCs) from 14 PsA and 9 OA patients were obtained and stored in TRIzol reagent. RNA was isolated by phenol-chloroform extraction and purified with RNeasy miniprep kits. Total RNA was...
CONCLUSIONS: Our study confirm that serum levels of vitamin D are significantly lower in psoriatic patients and correlate with the clinical severity of psoriasis; these data suggest that psoriatic patients could be screened for vitamin D insufficiency for a more comprehensive management. PMID: 29144098 [PubMed - as supplied by publisher]
Authors: Babino G, Esposito M, Bianchi L, Giunta A PMID: 29144096 [PubMed - as supplied by publisher]
This article is protected by copyright. All rights reserved. PMID: 29150844 [PubMed - as supplied by publisher]
CONCLUSIONS: These results indicate that liver inflammation and fibrosis is associated with experimental psoriasiform dermatitis. Our results suggest that psoriatic inflammation may be associated with specific liver injury. This article is protected by copyright. All rights reserved. PMID: 29150843 [PubMed - as supplied by publisher]
This article is protected by copyright. All rights reserved.
CONCLUSIONS: The marked reduction of C-Jun in SCC in comparison to normal skin and inflammatory skin dermatoses may refer to its tumor suppressor activity. C-Jun expression in SCC carries favorable prognosis. Absence of significant association between C-Jun and Ki-67 either in SCC or inflammatory skin diseases indicates that it does not affect proliferative capacity of cells. PMID: 29144206 [PubMed - as supplied by publisher]