National Strategy to Reduce Opioid Epidemic

Years of sustained and coordinated efforts will be required to contain and reverse the harmful societal effects of the prescription and illicit opioid epidemics, which are intertwined and getting worse, says a new National Academies report that was requested by the U.S. Food and Drug Administration. The report says it is possible to stem the still-escalating prevalence of opioid use disorder and other opioid-related harms without foreclosing access to opioids for patients suffering from pain. Some of the report's recommended actions include promoting more judicious prescribing of opioids, expanding access to treatment for opioid use disorder, preventing more overdose deaths, weighing societal impacts in opioid-related regulatory decisions, and investing in research to better understand the nature of pain and develop non-addictive alternatives.
Source: News from the National Academies - Category: Science Source Type: news

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More than 25 million Americans suffer from daily chronic pain, a highly debilitating medical condition that is complex and difficult to manage. In recent decades, there has been an overreliance on the prescription of opioids for chronic pain, contributing to a significant and alarming epidemic of opioid overdose deaths and addiction. Innovative scientific solutions to develop non-opioid, non-addictive alternative treatment options are thus urgently needed. One of the goals of the Helping to End Addiction Long-term (HEAL) Initiative is to accelerate the discovery and preclinical development of new medications and devices t...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
More than 25 million Americans suffer from daily chronic pain, a highly debilitating medical condition that is complex and difficult to manage. In recent decades, there has been an overreliance on the prescription of opioids for chronic pain, contributing to a significant and alarming epidemic of opioid overdose deaths and addiction. Innovative scientific solutions to develop non-opioid, non-addictive alternative treatment options are thus urgently needed. One of the goals of the Helping to End Addiction Long-term (HEAL) Initiative is to accelerate the discovery and preclinical development of new medications and devices t...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
AbstractOpioid-related death and overdose have now reached epidemic proportions. In response to this public health crisis, the National Institutes of Health (NIH) launched the Helping to End Addiction Long-term InitiativeSM, or NIH HEAL InitiativeSM, an aggressive, trans-agency effort to speed scientific solutions to stem the national opioid public health crisis. Herein, we describe two NIH HEAL Initiative programs to accelerate development of non-opioid, non-addictive pain treatments: The Preclinical Screening Platform for Pain (PSPP) and Early Phase Pain Investigation Clinical Network (EPPIC-Net). These resources are pro...
Source: Neurotherapeutics - Category: Neurology Source Type: research
Abstract Chronic pain is considered a public health crisis due to its high prevalence, impact, costs, and disparities in pain prevalence and treatment. In parallel, drug overdose, particularly due to opioids, has become an epidemic in the United States, prompting a public health crisis concerning harms associated with both prescribed opioid therapy for chronic pain and illicit opioid use. The purpose of this special issue is to highlight state-of-the-art psychological research that addresses the combined issues of chronic pain and harms associated with opioids. Articles included in this special issue focus on 2 re...
Source: The American Psychologist - Category: Psychiatry & Psychology Authors: Tags: Am Psychol Source Type: research
Deaths involving illicit opioids, stimulants (such as methamphetamine), heroin, and cocaine rose dramatically between 2015 and the end of 2019, according to areport released Monday by the AMA ’s Opioid Task Force.The report also showed a 37.1% decrease in opioid prescribing; wider use of state Prescription Drug Monitoring Programs; and increasing numbers of doctors trained to prescribe buprenorphine (a medication used for treating opioid use disorder).The trends indicate that the nature of the nation ’s drug overdose crisis has changed. “The nation’s drug overdose epidemic is now being driven predom...
Source: Psychiatr News - Category: Psychiatry Tags: AMA AMA Opioid Task Force buprenorphine CDC cocaine fentanyl heroin medication-assisted treatment mental health parity opioid use disorder opioids Patrice Harris stimulants Source Type: research
  What is the link between addiction and mental illness? Is addiction a choice? In today’s Not Crazy podcast, Gabe and Lisa discuss whether addiction should be classified as a disease and whether or not it should require medical treatment. Gabe also shares his personal story of addiction and how it tied in with his bipolar disorder. What’s your take? Tune in for an in-depth discussion which covers every angle of this often controversial topic. (Transcript Available Below) Please Subscribe to Our Show: And We Love Written Reviews!  About The Not Crazy podcast Hosts Gabe Howard is an award-winning...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Addiction General Mental Health and Wellness Not Crazy Podcast Recovery Source Type: blogs
ConclusionsWe reveal a novel role for the stress hormone cortisol in modulating the transport of opioids across the BBB, which could contribute to their abuse or overdose. Our updated BBB model represents a powerful tool available to researchers, clinicians, and drug manufacturers for understanding the mechanisms by which opioids access the CNS.
Source: Fluids and Barriers of the CNS - Category: Neuroscience Source Type: research
We describe the historical use of opioids and the scope of the current opioid crisis, review the differences between dependence and addiction, and the private and public sectors response to pain management and highlight the issue of adolescent vulnerability. We conclude with a proposal for future directions that address both public and patient health needs.
Source: Current Opinion in Anaesthesiology - Category: Anesthesiology Tags: PEDIATRIC ANESTHESIA: Edited by Jorge A. Gálvez Source Type: research
Background Opioids can induce significant respiratory depression when administered as analgesics for the treatment of acute, postoperative, and chronic pain. There are currently no pharmacologic means of reversing opioid-induced respiratory depression without interfering with analgesia. Further, there is a growing epidemic of opioid overdose that could benefit from therapeutic advancements. The aim of this study was to test the ability of two partial agonists of α4β2 nicotinic acetylcholine receptors, varenicline (used clinically for smoking cessation) and ABT 594 (tebanicline, developed as an analgesic), to red...
Source: Anesthesiology - Category: Anesthesiology Source Type: research
The overprescribing of opioid pain relievers (OPR) has led to a significant increase in opioid addiction and overdose. A cornerstone of combating the opioid epidemic is the development of peri-operative evidence based guidelines to standardize OPR prescribing practices and of opioid sparing Enhanced Recovery After Surgery (ERAS) protocols. ERAS has been found to reduce the volume of OPR prescribed while improving outcomes and overall patient satisfaction in adult gynecologic and multiple pediatric surgical specialties.
Source: Journal of Pediatric and Adolescent Gynecology - Category: OBGYN Authors: Source Type: research
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