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Labmade smallpox is possible, study shows

Source: ScienceNOW - Category: Science Authors: Tags: Pharmacology, Toxicology, Science and Policy, Virology In Depth Source Type: news

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DNA tests show it wasn't just smallpox that killed countless people after the Spaniards arrived in the New World
Source: Health News: CBSNews.com - Category: Consumer Health News Source Type: news
(University of Alberta Faculty of Medicine&Dentistry) UAlberta researchers created a new synthetic virus that could lead to the development of a more effective vaccine against smallpox. The discovery demonstrates how techniques based on the use of synthetic DNA can be used to advance public health measures.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
A study done in 1985 on a 16th century Italian mummy suggested that the two year old child had smallpox. Recent sequence analysis of tissues from the mummy now reveal the presence of hepatitis B virus, not smallpox virus. The sequence of the viral genome suggests that HBV entered the human population well before 1500. […]
Source: virology blog - Category: Virology Authors: Tags: Basic virology Information ancient dna hepatitis b virus high throughput sequencing mummy mutation rate phylogenetics viral viral evolution viruses Source Type: blogs
(Natural News) Using DNA samples from a 500-year old mummified remains of a child, researchers were able to crack the genetic code of an ancient strain of the hepatitis B virus (HBV). The finding, wherein scientists were able to “sequence the complete genome” of the virus, could help medical experts understand the intricacies of HBV, which is a...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
AbstractVaccination is amongst the best strategies to improve child survival and reduce morbidity. Vaccines represent the most cost effective and simple intervention to protect against distressing epidemics. There are mortality and morbidity related benefits derived from preventing infectious diseases through vaccination; these include financial benefits by avoiding hospitalization, preventing long-term disability and increased productivity. Ever since the invention of the first vaccine against smallpox by Edward Jenner in 1796, vaccination has become indispensable healthcare intervention and has saved millions of lives. D...
Source: Indian Journal of Pediatrics - Category: Pediatrics Source Type: research
For decades, scientists thought the toddler died nearly 500 years ago from smallpox. New research shows it carried hepatitis B.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Smallpox Mummies and Mummification Hepatitis Italy Source Type: news
Vaccinia virus (VACV) envelope protein D8 is one of three glycosaminoglycan adhesion molecules and binds to the linear polysaccharide chondroitin sulfate (CS). D8 is also a target for neutralizing antibody responses that are elicited by the smallpox vaccine, which has enabled the first eradication of a human viral pathogen and is a useful model for studying antibody responses. However, to date, VACV epitopes targeted by human antibodies have not been characterized at atomic resolution. Here, we characterized the binding properties of several human anti-D8 antibodies and determined the crystal structures of three VACV-mAb v...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Immunology Source Type: research
THURSDAY, Jan. 4, 2018 -- The mummified remains of an Italian boy who died 450 years ago suggest the hepatitis B virus has infected humans for centuries. The child died in the 16th century. And prior testing suggested smallpox killed him. But a new...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
(McMaster University) A team of scientists has sequenced the complete genome of an ancient strain of the Hepatitis B virus (HBV), shedding new light on a pervasive, complex and deadly pathogen that today kills nearly one million people every year. While little is known about its evolutionary history and origin, the findings confirm the idea that HBV has existed in humans for centuries.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
Gerd Sutter The highly attenuated Modified Vaccinia virus Ankara (MVA) lacks most of the known vaccinia virus (VACV) virulence and immune evasion genes. Today MVA can serve as a safety-tested next-generation smallpox vaccine. Yet, we still need to learn about regulatory gene functions preserved in the MVA genome, such as the apoptosis inhibitor genes F1L and E3L. Here, we tested MVA vaccine preparations on the basis of the deletion mutant viruses MVA-ΔF1L and MVA-ΔE3L for efficacy against ectromelia virus (ECTV) challenge infections in mice. In non-permissive human tissue culture the MVA deletion mutant vir...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
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