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Side effects not a major problem for new class of breast cancer drugs

(Wiley) A ground-breaking new class of oral drugs for treating breast cancer, known as cyclin-dependent kinase (CDK) inhibitors, are generally well-tolerated, with a manageable toxicity profile for most patients.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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BACKGROUNDIncreasing physical activity can improve cognition in healthy and cognitively impaired adults; however, the benefits for cancer survivors are unknown. The current study examined a 12‐week physical activity intervention, compared with a control condition, on objective and self‐reported cognition among breast cancer survivors. METHODSSedentary breast cancer survivors were randomized to an exercise arm (n = 43) or a control arm (n = 44). At baseline and at 12 weeks, objective cognition was measured with the National Institutes of Health Cognitive Toolbox, and self‐reported cognition...
Source: Cancer - Category: Cancer & Oncology Authors: Tags: Original Article Source Type: research
Publication date: 1 December 2017 Source:Colloids and Surfaces B: Biointerfaces, Volume 160 Author(s): R. Nazari-Vanani, N. Azarpira, H. Heli, K. Karimian, N. Sattarahmady Breast cancer is the top cancer and a main cause of death among women. The incidence of this cancer is increasing in the world. Sunitinib maleate is an oral, small-molecule, multi-targeted receptor tyrosine kinase inhibitor that inhibits tumor cell proliferation and angiogenesis, and has been administrated as an anticancer drug. Self-nanoemulsifying drug delivery system (SNEDDS) is an isotopic mixture of an oil, a surfactant and usually a co-surfactant,...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
AbstractAberrations of the cell cycle are pervasive in cancer, and selective cell cycle inhibition of cancer cells is a target of choice for a number of novel cancer therapeutics. Cyclin‐dependent kinases (CDKs) are key regulatory enzymes that control cell cycle transitions and the commitment to cell division. Palbociclib and ribociclib are both orally active, highly selective reversible inhibitors of CDK4 and CDK6 that are approved by the U.S. Food and Drug Administration (FDA) for hormone receptor‐positive metastatic breast cancer in combination with specific endocrine therapies. A third oral CDK4/6 inhibitor, abemac...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Review, Symptom Management and Supportive Care, Precision Medicine, Breast Cancer Source Type: research
Conclusion: This comprehensive manuscript demonstrates the versatility of recombinant protein-polymers to investigate drug carrier architectures. Furthermore, their facilitation of SC administration of poorly soluble drugs, like Rapa, may enable chronic self-administration in patients.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
ConclusionThis study allowed identification of three different profiles of ABC carrier-mediated transport: predominantly P-gp-dependent transport (dabigatran), preferential BCRP-dependent transport (apixaban) and approximately equivalent P-gp and BCRP-mediated transport (edoxaban and rivaroxaban).
Source: European Journal of Drug Metabolism and Pharmacokinetics - Category: Drugs & Pharmacology Source Type: research
Conclusion This qualitative analysis aimed to determine the accuracy of health information circulated by the alcohol industry on the links between alcohol and cancer. It found the industry and affiliated organisations use three main approaches: denial of the link between alcohol and cancer misinterpretation of the risk distraction by focusing on other risk factors This analysis highlights how these strategies could be detrimental to public health. Of course, it's possible, given this data was collected in 2016, that some of the websites and documents analysed by the researchers have since been updated. Regardless, the...
Source: NHS News Feed - Category: Consumer Health News Tags: Cancer Source Type: news
This article summarizes the milestones in the development of neratinib leadin g to this first approval for breast cancer.
Source: Drugs - Category: Drugs & Pharmacology Source Type: research
Conclusion Malnutrition is prevalent in elderly patients with cancer, and more frequent than in younger patients. There is a need for an early integration of the nutritional counselling in patients with cancer, and particularly in the elderly.
Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
In conclusion, our register‐based study of survival after cancer diagnosis showed that patients with diabetes had substantially poorer outcome in all measures. An association between baseline statin usage and lower all‐cause, cancer and cardiovascular mortality was modified by cancer type. The effect of statin use was largest for breast and colorectal cancer. Metformin usage in a subpopulation of oral antidiabetic users was in general associated with lower mortality, but this association was modified by cancer type. The association was strongest for liver, colorectal and breast cancer.
Source: International Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Cancer Epidemiology Source Type: research
Source: Physica Medica: European Journal of Medical Physics - Category: General Medicine Authors: Tags: SAAPMB 2017 Oral Presentations Source Type: research
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