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Side effects not a major problem for new class of breast cancer drugs

(Wiley) A ground-breaking new class of oral drugs for treating breast cancer, known as cyclin-dependent kinase (CDK) inhibitors, are generally well-tolerated, with a manageable toxicity profile for most patients.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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This study evaluated the cost-effectiveness of replacing standard intravenous therapy (taxane) with oral S-1 therapy for first-line metastatic breast cancer treatment.
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research
Conclusion These findings demonstrate the need to include OHL as a potential entity in the differential diagnosis of leukoplakic tongue lesions, regardless of the HIV status. Also, the presence of OHL in patient can promote the investigation of various explanations of EBV infection including immunosuppression due to HIV infection or chronic steroid use.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
Publication date: Available online 14 November 2017 Source:Pharmacological Research Author(s): Jing Wang, Changpei Gan, Rolf W. Sparidans, Els Wagenaar, Stéphanie van Hoppe, Jos H. Beijnen, Alfred H. Schinkel Encorafenib (LGX818) is a promising BRAFV600E inhibitor that has efficacy against metastatic melanoma. To better understand its pharmacokinetics, we studied its interactions with the multidrug efflux transporters ABCB1 and ABCG2 and the multidrug metabolizing enzyme CYP3A. In polarized MDCK-II cells, encorafenib was efficiently transported by canine and human ABCB1 and ABCG2 and by mouse Abcg2. Upon oral admin...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
SummaryThe goals of the present study were to define the anticancer activity of LFM-A13 ( α-cyano-β-hydroxy-β-methyl-N-(2,5-dibromophenyl)-propenamide), a potent inhibitor of Polo-like kinase (PLK), in a mouse mammary cancer model induced by 7,12-dimethylbenz(a)anthracene (DMBA)in vivo and explore its anticancer mechanism(s). We also examined whether the inhibition of PLK by LFM-A13 would improve the efficiency of paclitaxel in breast cancer growthin vivo. To do this, female BALB/c mice received 1  mg of DMBA once a week for 6 weeks with oral gavage. LFM-A13 (50 mg/kg body weight) was adminis...
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research
The Growing Toll of Our Ever-Expanding WaistlinesBy  JANE E. BRODY NOV. 13, 2017Paul Rogers I hope you ’re not chomping on a bagel or, worse, a doughnut while you read about what is probably the most serious public health irony of the last half century in this country: As one major killer — smoking — declined, another rose precipitously to take its place: obesity.Many cancer deaths were averted after millions quit lighting up, but they are now rising because even greater numbers are unable to keep their waistlines in check.Today, obesity and smoking remain the two leading causes of pre...
Source: Dr Portnay - Category: Cardiology Authors: Source Type: blogs
Publication date: Available online 11 November 2017 Source:The Journal of Steroid Biochemistry and Molecular Biology Author(s): Nighat Y. Sofi, Monika Jain, Umesh Kapil, Vuthaluru Seenu, Lakshmy R., Chander P. Yadav, Ravindra M. Pandey, Neha Sareen The study was conducted with an objective to investigate the association between reproductive factors, nutritional status and serum 25(OH)D levels among women diagnosed with breast cancer (BC). A total of 200 women with BC attending a tertiary healthcare institute of Delhi, India matched with 200 healthy women for age (±2years) and socio economic status were included in ...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
This study utilized a convenience sample (N=100) of Idaho residents. A self-designed, validated interview-administered questionnaire was administered by a data collection service using computer-assisted telephone interview software to assess consumer perceptions about cancer screenings. Data were analyzed using descriptive statistics, frequencies, and Pearson's Chi-Square tests.Results: Participants were predominantly white (90%) with a mean age of 52.7 years with some post-high school education (80%) and the majority had received OC screenings (54%).The majority of participants perceived benefits of each specific cancer s...
Source: Journal of Dental Hygiene - Category: Dentistry Tags: J Dent Hyg Source Type: research
ConclusionsLobular tumors were associated with older age at first birth, increased lactation duration, and current oral contraceptive use. Etiologic heterogeneity by histology persisted after restricting to Luminal A subtype, suggesting both tumor histology and intrinsic subtype play integral parts in breast cancer risk.
Source: Cancer Causes and Control - Category: Cancer & Oncology Source Type: research
Drinking alcohol, even modest amounts, increases the risk of breast cancer and other cancers.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Head and Neck Cancer Breast Cancer Esophageal Cancer Mouth Colon and Colorectal Cancer Liver Cancer Alcoholic Beverages Alcohol Abuse Advertising and Marketing Source Type: news
ConclusionsThe obtained targeted nanocarrier could overcome the limitations associated with the LTZ as a potent non-steroidal drug. Both the entrapment and therapeutic efficiency of letrozole in the amphiphilic carrier were increased using the lipid nanoparticles and the surface modification, respectively.
Source: Pharmaceutical Research - Category: Drugs & Pharmacology Source Type: research
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