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Side effects not a major problem for new class of breast cancer drugs

(Wiley) A ground-breaking new class of oral drugs for treating breast cancer, known as cyclin-dependent kinase (CDK) inhibitors, are generally well-tolerated, with a manageable toxicity profile for most patients.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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CONCLUSIONS: Topical InsP6 treatment has demonstrated to be effective and safe in preventing and/or mitigating chemotherapy-induced side effects as well as the preserving quality of life in women with ductal breast cancer. PMID: 28724186 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Conclusions: Saliva contains molecular information worthy of interrogation via EWAS. The simplicity of specimen collection suggests that saliva offers a practical alternative to blood for measurements that can be used to characterize individual exposomes. https://doi.org/10.1289/EHP1011 Received: 23 August 2016 Revised: 08 November 2016 Accepted: 18 November 2016 Published: 20 July 2017 Address correspondence to V. Bessonneau, Silent Spring Institute, 320 Nevada St., Suite 302, Newton, Massachusetts 02460 USA. Telephone: (617) 332-4288. Email: vincent.bessonneau@gmail.com The authors declare they have no actual or po...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
Conclusions: These results demonstrate the possibility to predict large-scale mixture effects for endocrine disrupters with a predictive toxicology approach that is suitable for high-throughput ranking and risk assessment. The size of the effects predicted is consistent with an increased risk of infertility in women from everyday exposures to our chemical environment. https://doi.org/10.1289/EHP742 Received: 30 June 2016 Revised: 07 December 2016 Accepted: 24 February 2017 Published: 19 July 2017 Address correspondence to F.Y. Bois, INERIS, DRC/VIVA, Parc ALATA, BP 2, 60550 Verneuil en Halatte, France. Telephone: 33-...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
Conclusions: In this prospective study, using an indoor wood-burning stove/fireplace in the longest adult residence at least once a week and burning either wood or natural gas/propane was associated with a modestly higher risk of breast cancer. https://doi.org/10.1289/EHP827 Received: 18 July 2016 Revised: 16 November 2016 Accepted: 09 December 2016 Published: 18 July 2017 Address correspondence to A.J. White, Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709-2233 USA. Telephone: (919) 316-4867. Email: alexandra.white@nih.gov Supp...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
Conclusion NCS without obvious odontogenic causes or trauma often signals systemic malignancy. It may be the first clue of occult malignancy.
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
In conclusion, patients value th e inclusion of educational and behavioural interventions in adherence apps. Developers of adherence apps should consider including tools for side effect self-management and provision of information to educate patients on their medications and disease condition.
Source: Journal of Cancer Education - Category: Cancer & Oncology Source Type: research
Conclusions: There was a discernible change in oral mucosal, salivary, and candidal status during the course of the study.
Source: Indian Journal of Dental Research - Category: Dentistry Authors: Source Type: research
Abstract Aberrations of the cell cycle are pervasive in cancer, and selective cell cycle inhibition of cancer cells is a target of choice for a number of novel cancer therapeutics. Cyclin-dependent kinases (CDKs) are key regulatory enzymes that control cell cycle transitions and the commitment to cell division. Palbociclib and ribociclib are both orally active, highly selective reversible inhibitors of CDK4 and CDK6 that are approved by the U.S. Food and Drug Administration (FDA) for hormone receptor-positive metastatic breast cancer in combination with specific endocrine therapies. A third oral CDK4/6 inhibitor, ...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Oncologist Source Type: research
Half of those asked in a Medscape survey rated neratinib, which is pending approval by the FDA later this month, as an important or very important alternative in treating HER2-positive breast cancer.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news
EXEMESTANE LOADED ALGINATE NANOPARTICLES FOR CANCER TREATMENT: FORMULATION AND IN VITRO EVALUATION. Int J Biol Macromol. 2017 Jul 12;: Authors: Joseph JJ, Sangeetha D Abstract Alginate, a biopolymer is most useful for anticancer drug delivery, because of it is biocompatible, nontoxic, biodegradable and exploiting ligand-receptor interaction. Breast cancer is spreading very fast due to the changing food habits and environmental causes. Exemestane (EXE) an oral chemotherapeutic drug was used to treat breast cancer, while loading EXE in alginate nanoparticles, the side effects which was faced during admi...
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Tags: Int J Biol Macromol Source Type: research
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