In vitro synergistic effects of a short cationic peptide and clinically used antibiotics against drug-resistant isolates of Brucella melitensis.

CONCLUSION: These results showed that by antibiotic-CM11 combination, their effective dose can be reduced particularly for drug-resistant isolates. In conclusion, considering the importance of brucellosis caused by B. melitensis in the Middle East beside reports on antibiotic resistance strains, especially against rifampin, which may literally lead to an increase in resistant strains of Mycobacterium tuberculosis in endemic areas, our findings can be used to develop a suitable alternative treatment for brucellosis, and with less risk.
PMID: 28699872 [PubMed - as supplied by publisher]

Source: Journal of Medical Microbiology - July 12, 2017 Category: Microbiology Authors: Mohammadi Azad Z, Moravej H, Fasihi-Ramandi M, Masjedian F, Nazari R, Mirnejad R, Moosazadeh Moghaddam M Tags: J Med Microbiol Source Type: research