New Study Finds Hope for Mesothelioma Treatment in Measles Virus,...

Minnesota scientists say a particular strain of the measles virus is especially lethal to malignant mesothelioma cells and may form the basis of a new treatment.(PRWeb July 13, 2017)Read the full story at http://www.prweb.com/releases/2017/07/prweb14499292.htm
Source: PRWeb: Medical Pharmaceuticals - Category: Pharmaceuticals Source Type: news

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The eighth annual International Symposium on Malignant Pleural Mesothelioma Saturday at UCLA will reflect the rapidly evolving philosophy on future treatment of this rare cancer. Change is coming. The Symposium, which was first held in 2011 to help bring awareness to lung-sparing surgery, will highlight groundbreaking discoveries and the latest advances in immunotherapy and gene therapy — believed to be the future of cancer care. The longtime chemotherapy and surgery standard-of-care routine is fading. The symposium at the Luskin Conference Center on the UCLA campus in Los Angeles will help explain why. “There ...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
Contributors : Tiphaine Delaunay ; JeanFran çois FonteneauSeries Type : Expression profiling by arrayOrganism : Homo sapiensWe used microarrays to analyse antiviral response by mesothelioma cells sensitive or resistant to the oncolytic activity of measles virus
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Thoracic surgeon Dr. Shanda Blackmon at the Mayo Clinic in Rochester, Minnesota, believes there is a place for cryotherapy in the future multidisciplinary treatment of pleural mesothelioma. She wants to show it with this groundbreaking clinical trial. “We think [cryotherapy] could play an important role in treatment,” Blackmon told Asbestos.com. “So far, things look promising, but you can’t say anything specific without more numbers. Right now, it’s a little like telling a story.” Cryotherapy involves destroying cancer cells, or any abnormal tissues, by freezing them with controlled nitr...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: ADI-PEG 20 cryoablation cryotherapy intrapleural measles virus Mayo Clinic mesothelioma clinical trial Opdivo pacific mesothelioma center pleural mesothelioma pleuroscopy Shanda Blackmon Surgery for Mesothelioma After Radiation Thera Source Type: news
Authors: Jacobson BA, Sadiq AA, Tang S, Jay-Dixon J, Patel MR, Drees J, Sorenson BS, Russell SJ, Kratzke RA Abstract Malignant mesothelioma has a poor prognosis for which there remains an urgent need for successful treatment approaches. Infection with the Edmonston vaccine strain (MV-Edm) derivative of measles virus results in lysis of cancer cells and has been tested in clinical trials for numerous tumor types including mesothelioma. Many factors play a role in MV-Edm tumor cell selectivity and cytopathic activity while also sparing non-cancerous cells. The MV-Edm receptor CD46 (cluster of differentiation 46) was ...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Immunotherapy through clinical trials is becoming a promising treatment option for some mesothelioma patients. Checkpoint inhibitor drugs, such as Keytruda, already have U.S. Food and Drug Administration (FDA) approval as first-line treatments for non-small cell lung cancer (NSCLC), edging immunotherapy drugs closer to becoming a viable second-line therapy for other thoracic cancers, including pleural mesothelioma. However, overall response to immune therapies remains relatively low. Researchers across the country are striving to enhance responsiveness to immunotherapy drugs. Leading that trend is viroimmunotherapy, or t...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: Biomedicines checkpoint blockade Checkpoint inhibitor drugs clinical trials for mesothelioma Dr. Alexander Dash Dr. Manish Patel FDA approval Keytruda immune response cancer immunotherapy response mesothelioma intratumoral injections k Source Type: news
Abstract Attenuated Edmonston lineage measles virus (MV-Edm) vaccine strains can preferentially infect and lyse a wide variety of cancer cells. Oncolytic MV-Edm derivatives genetically engineered to expressed the human carcinoembryonic antigen (MV-CEA virus) or the human sodium iodide symporter (MV-NIS virus) and are currently being tested in clinical trials against ovarian cancer, glioblastoma multiforme, multiple myeloma, mesothelioma, head and neck cancer, breast cancer and malignant peripheral nerve sheath tumors. This review describes the basic and preclinical data that facilitated the clinical translation of...
Source: Current Cancer Drug Targets - Category: Cancer & Oncology Authors: Tags: Curr Cancer Drug Targets Source Type: research
One of the main causes of health care dysfunction identified by demoralized health care professionals in our 2003 qualitative study was threats to evidence-based medicine, and by extension, evidence-based public health and health policy.(1) Since then, we have frequently discussed threats such asmanipulation andsuppression of clinical research to further vested interests, and distortion of research dissemination, such asghost written articles, often enabled byindividual andinstitutional conflicts of interest.These and other causes of health care dysfunction which we discuss, however, have hardly been the stuff of political...
Source: Health Care Renewal - Category: Health Management Tags: asbestos Donald Trump evidence-based medicine health policy public health Source Type: blogs
The Mayo Clinic in Rochester, Minnesota, opened a mesothelioma clinical trial involving intrapleural cryotherapy before surgery to trigger an anti-tumor response. It is the only cryotherapy clinical trial for mesothelioma conducted in the U.S. Two previous cryotherapy trials for mesothelioma at other cancer centers in 2009 and 2011 were withdrawn or terminated. Cryotherapy involves dissipating small cancer tumors by freezing them with controlled nitrogen vapors. It has been used with other cancers, but it remains a controversial procedure as an adjuvant therapy for mesothelioma. The Pacific Meso Center in Los Ang...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: Treatment & Doctors Source Type: news
Authors: Achard C, Boisgerault N, Delaunay T, Roulois D, Nedellec S, Royer PJ, Pain M, Combredet C, Mesel-Lemoine M, Cellerin L, Magnan A, Tangy F, Grégoire M, Fonteneau JF Abstract Attenuated measles virus (MV) is currently being evaluated as an oncolytic virus in clinical trials and could represent a new therapeutic approach for malignant pleural mesothelioma (MPM). Herein, we screened the sensitivity to MV infection and replication of twenty-two human MPM cell lines and some healthy primary cells. We show that MV replicates in fifteen of the twenty-two MPM cell lines. Despite overexpression of CD46 by a m...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Conditions:   Recurrent Malignant Mesothelioma;   Stage IA Malignant Mesothelioma;   Stage IB Malignant Mesothelioma;   Stage II Malignant Mesothelioma;   Stage III Malignant Mesothelioma;   Stage IV Malignant MesotheliomaInterventions:   Biological: oncolytic measles virus encoding thyroidal sodium iodide symporter;   Other: laboratory biomarker analysis;   Procedure: single photon emission computed tomography;   Procedure: computed tomographySponsors:   Mayo&...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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