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The Eating Assessment Tool-10 Predicts Aspiration in Adults with Stable Chronic Obstructive Pulmonary Disease

This study investigates the ability of the Eating Assessment Tool (EAT-10) to predict aspiration during objective dysphagia evaluation in adults with stable COPD. Thirty adults (20 male, 10 female; mean age  = 69.07 ± 16.82) with stable COPD attended an outpatient dysphagia clinic for a fiberoptic endoscopic evaluation of swallowing (FEES) in an acute teaching hospital (January 2015–November 2016). During evaluations, individuals completed an EAT-10 rating scale followed immediately by a standar dised FEES exam. Aspiration status during FEES was rated using the penetration–aspiration scale by clinicians blinded to EAT-10 scores. Data were retrospectively analysed. Significant differences in mean EAT-10 scores were found between aspirators (16.3; SEM = 2.165) and non-aspirators (7.3; SEM  = 1.009) (p = 0.000). The EAT-10 predicted aspiration with a high level of accuracy (AUC = 0.88). An EAT-10 cut-off value of>9 presented a sensitivity of 91.67, specificity of 77.78 with positive and negative likelihood ratios of 4.12 and 0.11, respectively. Positive and negative predictive values were 73.30 and 93.30, respectively. Diagnostic odds ratio was 38.50 (p 
Source: Dysphagia - Category: Speech-Language Pathology Source Type: research

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This study aims to determine the impact of early surgery and comorbid conditions on the outcomes of NSTIs.MethodsA retrospective cohort study was performed on all subjects presenting with NSTI at an academic medical center between 2005 and 2016. Patients were identified based on ICD codes. Those under the age of 18 or with intraoperative findings not consistent with NSTI diagnosis were excluded.ResultsThere were 115 patients with a confirmed diagnosis of NSTI with a mean age of 55  ± 18 years; 41% were females and 55% were diabetics. Thirty percent of patients underwent early surgery (
Source: European Journal of Trauma and Emergency Surgery - Category: Emergency Medicine Source Type: research
ResMed (NYSE:RMD) today released data from two clinical analyses exploring combined home oxygen therapy and non-invasive ventilation therapy for patients with persistent hypercapnia following a life-threatening exacerbation of chronic obstructive pulmonary disorder, touting an increase in cost efficiency with the combined therapy. Results from the two studies, performed in the U.K. and the US, were presented at the ATS 2018 International Conference this week, the San Diego-based company said. Data from the U.K.-based study reported that the combined home treatments reduced exacerbation frequency and 28-day hospital re...
Source: Mass Device - Category: Medical Devices Authors: Tags: Clinical Trials Respiratory ResMed Inc. Source Type: news
Conclusions: MAC and M. kansasii were the most prevalent species involved in NTMLD in the state, similarly to what occurs in other regions of Brazil. Data on regional epidemiology of NTMLD, its specific etiology, and associated conditions are essential to establish appropriate treatment, since each species requires specific regimens. Most patients with NTMLD had received previous tuberculosis treatment, which might lead to development of resistance and late diagnosis.RESUMO Objetivo: A incid ência de doença pulmonar causada por micobactérias não tuberculosas (MNT) tem aumentado em todo o mundo. N...
Source: Jornal Brasileiro de Pneumologia - Category: Respiratory Medicine Source Type: research
Conditions:   COPD;   Chronic Obstructive Pulmonary Disease Intervention:   Device: AIR-AD Sponsors:   Right-Air;   University of Pennsylvania Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
(Intermountain Medical Center) Researchers have developed a new tool that utilizes basic laboratory tests to effectively identify patients with chronic obstructive pulmonary disease who are at high risk of being hospitalized due to a flare up of the condition.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
The inflammatory biomarker soluble urokinase plasminogen activator receptor (suPAR) is elevated in severe acute and chronic medical conditions and has been associated with short-term mortality. The role of suP...
Source: Respiratory Research - Category: Respiratory Medicine Authors: Tags: Research Source Type: research
eleszko Many studies have been undertaken to reveal how tobacco smoke skews immune responses contributing to the development of chronic obstructive pulmonary disease (COPD) and other lung diseases. Recently, environmental tobacco smoke (ETS) has been linked with asthma and allergic diseases in children. This review presents the most actual knowledge on exact molecular mechanisms responsible for the skewed inflammatory profile that aggravates inflammation, promotes infections, induces tissue damage, and may promote the development of allergy in individuals exposed to ETS. We demonstrate how the imbalance between oxidant...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Review Source Type: research
Improved prediction modeling in osteoarthritis (OA) may encourage risk reduction through calculation of individual and population lifetime risks. There are currently no prediction models for hand OA. Thus, we aimed to i) develop a prediction model for hand OA in men and ii) to contrast its discriminative performance to a prediction model for lung cancer and chronic obstructive pulmonary disease (COPD).
Source: Osteoarthritis and Cartilage - Category: Rheumatology Authors: Source Type: research
Publication date: 15 September 2018 Source:Journal of Molecular Structure, Volume 1168 Author(s): Lei-Lei Huang, Jie Han, Jian-Xiong Ran, Xiu-Ping Chen, Zhong-Hua Wang, Fan-Hong Wu Dipeptidyl peptidase I (DPPI) inhibitors have potential use in the treatment of neutrophil inflammatory diseases, such as chronic obstructive pulmonary disease. The three-dimensional quantitative structure-activity relationship (3D-QSAR) model was established in this paper based on the computational biology method for 32 DPPI inhibitor compounds. Good predictability was obtained based on the application of the comparative molecular field analys...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: Available online 20 May 2018 Source:Peptides Author(s): Takeshi Tokudome, Kentaro Otani, Mikiya Miyazato, Kenji Kangawa Ghrelin, a growth hormone–releasing peptide that was first discovered in the stomach of rats in 1999, is an endogenous ligand of growth hormone secretagogue receptor. Ghrelin exerts its potent growth hormone–releasing and orexigenic activities by binding to specific receptors in the brain. Subsequent studies showed that ghrelin participates in the regulation of diverse processes, including energy balance, body weight maintenance, and glucose and fat metabolism, and demonstra...
Source: Peptides - Category: Biochemistry Source Type: research
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